COVID Support from MGGM to NIAID Investigators

NIH Pandemic-Era Grants

Pandemic Era Grants

2020

↗ Live URL (may be dead)

Document text

Principal Investigator: William  Elkins
Organization: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Fiscal Year: 2020
Award: $57,413
Funding agency: National Institute of Allergy and Infectious Diseases

MGGM initiated several collaborative projects for creating genetically engineered animal models for understanding the mechanisms of novel SARS-CoV2 virus transmission and therapeutic targets. 
Novel corona virus SARS-CoV2 is responsible for the COVID-19. Angiotensin Converting Enzyme 2 (ACE2), the receptor for SARS-CoV2 present on the cell surface of most cells, is responsible for entry of virus into the cell. On the other hand, a serine protease TMPRSS2, is involved in priming the spike (S) protein of the virus. In collaboration with LCIM, mouse models are being created to understand the mechanisms of viral entry, transmission and therapeutics.  MGGM also played a critical role in cryopreserving the existing and on-going breeding colonies during the COVID-19 crisis. Approx. 130 lines of mice were cryopreserved for over 15 different labs.

Terms: <2019 novel coronavirus><2019-nCoV><Angiotensin Converting Enzyme><Angiotensin I-Converting Enzyme><Animal Model><Animal Models and Related Studies><Breeding><CD143 Antigens><COVID><COVID-19><COVID19><CRISPR><CRISPR/Cas system><Carboxycathepsin><Cell Body><Cell surface><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><CoV disease><Collaborations><Cryofixation><Cryopreservation><Dipeptidyl Peptidase A><Epitheliasin Gene><Gene-Modified><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Investigators><Kininase A><Kininase II><Mice><Mice Mammals><Murine><Mus><NIAID><National Institute of Allergy and Infectious Disease><PRSS10><Peptidyl-Dipeptidase A><Play><Receptor Protein><Recombinant DNA Technology><Research Personnel><Researchers><Role><SARS Virus><SARS corona virus><SARS coronavirus><SARS-Associated Coronavirus><SARS-CoV><SARS-CoV-2><SARS-CoV2><SARS-Related Coronavirus><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Serine Endopeptidases><Serine Protease><Serine Protein Hydrolases><Serine Proteinases><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe acute respiratory syndrome coronavirus 2><TMPRSS2><TMPRSS2 gene><Therapeutic><Transmission><Viral><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virus><Wuhan coronavirus><cold preservation><cold storage><corona virus disease><corona virus disease 2019><coronavirus disease><coronavirus disease 2019><gene modification><genetically engineered><model of animal><model organism><mouse genetics><mouse model><murine model><novel><receptor><severe acute respiratory syndrome-CoV><social role><therapeutic target><transmission process><viral transmission><virus protein><virus transmission>