Animal Models of Emerging Viral Infection
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Principal Investigator: Daniel S Chertow Organization: CLINICAL CENTER Fiscal Year: 2024 Funding agency: NIH Clinical Center Project 1: We previously developed a NHP ICU model in healthy (uninfected) NHPs. We have extended this model to included supportive care of animals infected with E.coli or K. pneumoniae. Among K. pneumoniae infected animals, we have completed a bacterial dose-response study. The manuscript is has been submitted for publication and is undergoing peer-review. We are now proceeding with our first intervention trial with a host-targeted potential therapy for K. pnuemoniae sepsis. Additionally, we have completed a 2-animal pilot study providing supportive critical care to NHPs infected with Ebola virus. This study was successfully implemented in the NIAID biosafety-level (BSL)-4 Integrated Research Facility (IRF) in Fredrick, MD and has been published. In the coming year we will evaluate pathogenes of lower doses of EBOV infection in NHPs. The goal of this work will be to establish a model that more closes represents timing of severity of infection in humans. Terms: <Animal Model><Animal Models and Related Studies><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Approaches to prevention><Bacteremia><Clinical><Clinical Management><Critical Care><Critical Illness><Critically Ill><Diagnosis><Dose><Dysfunction><E coli><E. coli><EBOV><Ebola virus><Ebola-like Viruses><Emerging infection><Escherichia coli><Failure><Functional disorder><Goals><Human><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Individual><Infection><Intensive Care Units><Intervention Trial><Interventional trial><K pneumoniae><K. pneumoniae><Klebsiella pneumoniae><Manuscripts><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><NIAID><National Institute of Allergy and Infectious Disease><Organ><Pathogenesis><Peer Review><Phylogenetic Analysis><Phylogenetics><Physiologic><Physiological><Physiopathology><Pilot Projects><Prevention approach><Publications><Publishing><Research><Scientific Publication><Sepsis><Severities><Supportive Therapy><Supportive care><Syndrome><Viral Diseases><Virus Diseases><Work><animal care><bacteraemia><bacterial sepsis><blood infection><bloodstream infection><emergent infection><improved><model of animal><pathophysiology><pilot study><research facility><response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><viral infection><virus infection><virus-induced disease>