Collaborative Project

NIH Pandemic-Era Grants

Pandemic Era Grants

2024

↗ Live URL (may be dead)

Document text

Principal Investigator: Ramnik J Xavier
Organization: MASSACHUSETTS GENERAL HOSPITAL
Fiscal Year: 2024
Award: $250,499
Funding agency: National Institute of Allergy and Infectious Diseases

Project Summary/Abstract (Collaborative Project)
In this project a set of recently developed experimental and computational tools for antigen
discovery will be utilized to identify antigens of microbial and self origin in IgG4-related disease
and in systemic sclerosis. The focus will be to identify T cell antigens from the microbiome and
from the host extracellular matrix. Detailed metagenomic analyses of the microbiome will be
performed to identify microbial antigens of relevance. In addition, peptide antigens from the host
extracellular matrix will be screened for presentation by MHCII and evidence of T cell
immunogenicity. Finally, attempts will be made to identify shared T cell epitopes derived from
host and microbial antigens that are targeted by B cells.

Terms: <Address><Antigen Presentation><Antigen Targeting><Antigens><Autoantigens><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Automobile Driving><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Body Tissues><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CSIF><CSIF-10><Causality><Cell-Extracellular Matrix><Clonal Expansion><Collaborations><Computational toolkit><Cytokine Synthesis Inhibitory Factor><Disease><Disorder><Dominant Genetic Conditions><Dominant trait><ECM><Etiology><Exhibits><Extracellular Matrix><Fibrosis><Flare><Functional Metagenomics><Genetic Dominant><Genetic predisposing factor><IL-10><IL10><IL10A><IgG4-related disease><Immune Monitoring><Immunity><Immunologic Monitoring><Immunological Monitoring><Immunomonitoring><Inflammation Mediators><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Interleukin 10 Precursor><Interleukin-10><Longitudinal Studies><Metagenomics><Microbe><Pathogenesis><Pathogenicity><Pathologic><Patients><Peptides><Phenotype><Play><Production><Profibrotic factor><Profibrotic signal><Property><Role><SARS><SARS coronavirus disease><SARS-CoV disease><Self Tolerance><Self-Antigens><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome coronavirus disease><Specificity><Systemic Scleroderma><Systemic Sclerosis><T cell response><T-Cell Epitopes><T-Cells><T-Lymphocyte><T-Lymphocyte Epitopes><T4 Cells><T4 Lymphocytes><Technology><Tissues><analyze microbiome><antigen-specific T cells><autoimmune attack><autoimmune condition><autoimmune destruction><autoimmune disorder><autoimmune pathogenesis><autoimmunity disease><autoreactive T cell><causation><computational toolbox><computational tools><computational toolset><computerized tools><cytotoxic><disease causation><disease classification><disorder classification><driving><experience><genetic risk factor><immunogen><immunogenic><immunogenicity><inflammatory disease of the intestine><inflammatory disorder of the intestine><inflammatory mediator><inherited factor><intestinal autoinflammation><long-term study><longitudinal outcome studies><longterm study><microbial><microbial antigen><microbiome><microbiome analysis><microbiome signature><microorganism antigen><molecular phenotype><nosology><progressive systemic sclerosis><response><self-reactive T cell><social role><thymus derived lymphocyte><virtual>