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Principal Investigator: Gabriel Chamie
Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Fiscal Year: 2024
Award: $196,250
Funding agency: National Institute on Alcohol Abuse and Alcoholism
Project Summary
Dr. Gabriel Chamie is an infectious diseases physician and Associate Professor of Medicine in the Division of
HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco (UCSF). His
research has focused on developing effective approaches to promote community-based diagnosis of HIV, TB
and SARS-CoV-2, and engagement in HIV and TB prevention and treatment, with a more recent focus on
persons with unhealthy alcohol use in East Africa. He has over a decade of experience mentoring numerous
early-stage investigators (ESI), including pre- and post-doctoral investigators and junior faculty, and now seeks
the protected time of a K24 award to focus greater attention and time on mentoring, mentorship training and
expanding his research program at the intersection of HIV and alcohol use. In this application, Dr. Chamie
proposes a comprehensive mentorship, mid-career development, and research plan to address the challenge
of reaching and engaging populations at increased risk of HIV in biomedical HIV prevention from alcohol
drinking venues in East Africa. Despite a growing number of efficacious biomedical HIV prevention options, a
major challenge remains reaching persons at highest risk of HIV – such as adults at alcohol drinking venues –
who do not routinely engage in medical care, to overcome barriers to HIV prevention initiation and retention,
including alcohol use. To further develop and expand his patient-oriented research (POR) program and
mentoring, he proposes mid-career training in methods that support the application of quantitative preference
elicitation and human-centered design for intervention development, and additional training in mentorship.
Leveraging the infrastructure of his recently awarded R01 (the OPAL trial) and the ongoing SEARCH-
SAPPHIRE trial, Dr. Chamie proposes research in this application to: a) elicit preferences for biomedical HIV
prevention service delivery among adults at high risk of HIV who attend drinking venues in rural Kenya and
Uganda, b) to adapt the SAPPHIRE trial’s clinic-based “dynamic PrEP/PEP choice” intervention for community-
based delivery to this population at or near drinking venues, and c) to assess uptake, retention, and adherence
to biomedical prevention in a pilot trial of community-based biomedical prevention delivery among adults who
attend or work at drinking venues in rural Kenya and Uganda. With the guidance of an experienced senior
mentorship team, Dr. Chamie will utilize multiple ongoing research projects, and long-standing research
collaborations between UCSF and Makerere University in Uganda and the Kenya Medical Research Institute in
Kenya, to provide mentees with a robust infrastructure on which to develop their research interests and support
US-East African ESI partnerships in POR. The K24 award is instrumental to supporting him in achieving his
long-term goals of becoming a global leader in HIV and alcohol use research and mentoring future leaders in
patient-oriented research from the US and East Africa.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><AIDS Virus><AIDS prevention><AIDS test><AIDS/HIV test><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Adult><Adult Human><Africa><Africa South of the Sahara><African><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Anti-HIV Positivity><Approaches to prevention><Attention><Award><Awareness><COVID-19 virus><COVID19 virus><California><Caring><Clinic><Clinical Trials><CoV-2><CoV2><Collaborations><Communicable Diseases><Communities><Community Trial><Consumption><Counseling><Country><Educational workshop><Effectiveness><EtOH abuse><EtOH drinking><EtOH use><Facility Accesses><Faculty><Future><Goals><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Prevention><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV diagnosis><HIV test><HIV-1 test><HIV-2 test><HIV/AIDS prevention><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><HTLV-III Infections><HTLV-III Seroconversion><HTLV-III Seropositivity><HTLV-III-LAV Infections><Health Care Providers><Health Facilities><Health Personnel><Health care facility><Healthcare Facility><Healthcare Providers><Healthcare worker><High-Risk Sex><Hot Spot><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Human immunodeficiency virus test><Incidence><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Infrastructure><Intervention><Intervention Strategies><Interview><Investigators><K24 Award><K24 Mechanism><K24 Program><Kenya><LAV-HTLV-III><Lymphadenopathy-Associated Virus><M. tuberculosis/HIV><Measures><Medical><Medical Research><Medicine><Mentors><Mentorship><Methods><Mid-Career Clinical Scientist Award (K24)><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><Perception><Persons><Physicians><Play><Population><PrEP><Prevalence><Preventative intervention><Prevention><Prevention Research><Prevention approach><Prophylactic treatment><Prophylaxis><R-Series Research Projects><R01 Mechanism><R01 Program><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Research><Research Grants><Research Institute><Research Personnel><Research Project Grants><Research Projects><Researchers><Risk><Risk Factors><Role><Rural><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><San Francisco><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Site><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Time><Training><Transmission><Uganda><Universities><Unprotected Sex><Unsafe Sex><Viral><Virus-HIV><Work><Workshop><Wuhan coronavirus><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><adulthood><alcohol co-abuse><alcohol ingestion><alcohol intake><alcohol misuse><alcohol problem><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><arm><associate faculty><associate professor><care facilities><career><career development><community intervention><community level intervention><community setting><community-based intervention><condomless intercourse><condomless sex><coronavirus disease 2019 virus><coronavirus disease-19 virus><cost><develop therapy><drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol use><experience><female sex worker><hCoV19><hazardous alcohol use><health care access><health care availability><health care personnel><health care service access><health care service availability><health care worker><health provider><health workforce><healthcare access><healthcare accessibility><healthcare availability><healthcare personnel><healthcare service access><healthcare service availability><high risk><human centered design><implementation framework><implementation outcomes><implementation research framework><implementation science framework><improved><innovate><innovation><innovative><interest><intervention delivery><intervention development><intervention for prevention><interventional strategy><medical personnel><member><mid-career faculty><midcareer faculty><nCoV2><novel><outreach><patient centered><patient oriented><patient oriented research><patient oriented study><person centered><pilot test><pilot trial><postdoctoral investigator><pre-doc><pre-doctoral><pre-exposure prophylaxis><predoctoral><preference><prevention effectiveness><prevention intervention><prevention service><preventional intervention strategy><preventive intervention><primary outcome><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><programs><prototype><reach, efficacy, adoption, implementation, and maintenance><recruit><service delivery><sex><social role><social stigma><stigma><testing services><therapy development><transactional sex><transmission process><treatment development><treatment provider><treatment services><unhealthy alcohol use><unprotected intercourse><uptake>