Document text
Principal Investigator: William Adam Grobman
Organization: NORTHWESTERN UNIVERSITY AT CHICAGO
Fiscal Year: 2024
Award: $698,088
Funding agency: National Heart Lung and Blood Institute
ABSTRACT
A growing number of studies has implicated maternal stress as an explanation for the higher burden of adverse
pregnancy outcomes (APOs) seen among non-Hispanic Black women compared with their non-Hispanic White
counterparts. Most studies that have explored the relationship between stress and APOs have focused solely
on prenatal exposure to stressors, but Black women are generally exposed to more stressors over the life
course than White women. Moreover, Black women may have more limited resources to cope with social
stressors, as well as be more likely to experience enduring stressors like racial and/or gender discrimination,
which may lead to dysregulated physiological and psychological responses to everyday stressors (i.e., stress
reactivity). Several studies have shown dysregulated cardiovascular, neuroendocrine, and affective reactivity to
stressors is associated with increased CVD risk and other adverse health outcomes in non-pregnant
populations, but the impact of dysregulated stress reactivity on pregnancy outcomes remains poorly
understood. Thus, the overall goal of this study is to examine the impact of physiological and psychological
stress reactivity on adverse placental and pregnancy outcomes. We will use ecological momentary
assessments and intensive measurements of heart rate variability, blood pressure, salivary cortisol, and
positive and negative affect to generate personalized measures of how pregnant women respond to stressful
experiences in their daily lives. We will then examine associations of these measures with adverse placental
lesions and pregnancy outcomes. Finally, we will quantify the extent to which stress reactivity and exposure to
stressors during pregnancy account for racial disparities in these adverse outcomes.
Terms: <0-11 years old><Aeroseb-HC><Affective><Black><Black race><Blood Pressure><Blood Vessels><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caucasian Females><Caucasian Women><Cell Body><Cells><Cells Placenta-Tissue><Cellular Immune Function><Cetacort><Child><Child Youth><Children (0-21)><Chronic><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Decidua Basalis><Dermacort><Disparities><Disparity><Ecological momentary assessment><Economic Income><Economical Income><Education><Educational aspects><Eldecort><Environment><Event><Exposure to><Face><Frequencies><Future><Gestation><Goals><Health><Health Inequity><Health behavior><Heart Vascular><Histologic><Histologically><Histology><Hydrocortisone><Hydrocortone><Hypertension><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><Hytone><Immune system><Income><Individual><Inequalities in Health><Inequities in Health><Inequity><Inflammation><Laboratories><Lesion><Life><Life Cycle><Life Cycle Stages><Maternal placenta><Measurement><Measures><Mediating><Mothers><Neighborhoods><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Non-Hispanic><Nonhispanic><Normal Placentoma><Not Hispanic or Latino><Nulliparas><Nulliparity><Nulliparous><Nutracort><Outcome><Participant><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Placenta><Placenta Embryonic Tissue><Placentome><Play><Population><Pregnancy><Pregnancy Outcome><Pregnant Women><Premature Birth><Prematurely delivering><Preterm Birth><Proctocort><Psychologic Stress><Psychological Stress><Reaction><Reporting><Research><Research Resources><Resources><Risk><Salivary><Severities><Sex Discrimination><Small for Gestational Age Infant><Socio-economic status><Socioeconomic Status><Stress><Stress and Coping><Stressful Event><Testing><Time><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><White Females><White Women><Woman><adverse consequence><adverse outcome><adverse pregnancy outcome><biological adaptation to stress><black female><black women><black/white disparity><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular risk><cardiovascular risk factor><circulatory system><coping><coping with stress><differences due to race><differences in race><differs by race><differs in race><discrimination based on race><discrimination due to race><disparities in race><disparity due to race><expectant mother><expecting mother><experience><exposed in utero><faces><facial><fetal exposure><fetal stress><gender discrimination><health inequalities><health related behavior><heart rate variability><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><hypothalamic><immune function><in utero exposure><incomes><inequality due to race><inequity due to race><insight><intra-uterine environmental exposure><intrauterine environmental exposure><kids><life course><maternal stress><mortality><negative affect><negative affectivity><neonatal morbidity><newborn morbidity><pregnancy disorder><pregnant mothers><premature childbirth><premature delivery><prenatal exposure><prenatal stress><prenatally exposed><preterm delivery><psychologic><psychological><race based differences><race based disparity><race based inequality><race based inequity><race differences><race discrimination><race disparity><race related differences><race related disparity><race related inequality><race related inequity><race-based discrimination><race-related discrimination><racial difference><racial discrimination><racial disparity><racial inequality><racial inequity><racially different><racially unequal><reaction; crisis><response><small for gestational age><social stresses><social stressor><socio-economic position><socioeconomic position><stress reactivity><stress response><stress-related coping><stress; reaction><stressed mothers><stressful experience><stressful life event><stressful life experience><stressor><vascular><youngster>