Document text
Principal Investigator: Anthony Spirito
Organization: BROWN UNIVERSITY
Fiscal Year: 2024
Award: $141,317
Funding agency: National Institute of Mental Health
PROJECT SUMMARY/ABSTRACT
The preteen years are a critical period in which to study the development of suicidal thoughts and behavior
(STB). During this period, youth experience changes in emotion regulation and develop cognitive capacities
that include an emerging understanding of the permanence of death, which in turn affect the expression of
STB. However, as noted in the 2021 NIMH- Sponsored Research Round Table Series: Risk, Resilience, and
Trajectories in Preteen Suicide, research on preteen STB has been hindered by the field’s failure to focus on
an accurate, and thorough, assessment of STB in this age group. This application seeks to develop and test a
comprehensive approach to the assessment of preteen STB that includes child and parent/guardian self-
report, clinician interviews, an implicit association test, a death understanding interview, and observational
measures. In order to address this question, this application will examine both concurrent and predictive
validity of the assessment approach in preteens receiving intensive psychiatric services (inpatient or partial
hospitalization) who have a range of internalizing and externalizing symptoms, as well as a range of STB. We
will recruit 360 preteens at Bradley Hospital/Brown Medical School and the Johns Hopkins School of Medicine,
ensuring a diverse sample of children. In addition to refining the assessment of preteen STB, we will also: 1)
conduct a thorough clinical assessment of related symptomatology to better inform clinical practice, and 2)
examine mechanisms hypothesized to underlie preteen STB, using an RDoC-informed approach. We will also
examine which co- occurring symptoms and mechanisms significantly improve predictive validity for adverse
clinical STB outcomes above that of the STB assessment alone. This assessment approach is innovative in
that it is the first study to develop a multi-modal, multi-informant assessment approach for preteen STB
including use of real-time observational strategies, as well as an implicit association test. This is significant
because we are studying the most high-risk population of preteens with STB and we will be able to delineate
mechanisms related to preteen STB. This work addresses: NIMH Strategic Objective 2.1.B “Characterize the
emergence and progression of mental illnesses”, 2.2.A “Determining early risk and protective factors and
related mechanisms”, and 2.2.B“Developing reliable and robust biomarkers and assessment tools to predict
illness onset, and course, across diverse populations”.
Terms: <0-11 years old><11 year old><11 years of age><Active Follow-up><Address><Affect><Assessment instrument><Assessment tool><Behavior><Behavior assessment><Behavioral><Biological Markers><Cessation of life><Child><Child Youth><Children (0-21)><Clinical><Clinical assessments><Day Care><Death><Development><Emotional><Ensure><Failure><Feeling suicidal><Future><Goals><Hospitals><Implicit Association Test><Inpatients><Interview><Lead><Measures><Mental disorders><Mental health disorders><NIMH><National Institute of Mental Health><Onset of illness><Parents><Partial Hospitalization><Patient Self-Report><Pb element><Population Heterogeneity><Psychiatric Disease><Psychiatric Disorder><Psychiatric therapeutic procedure><RDoC><Research><Research Domain Criteria><Risk><Risk Factors><Sampling><Self-Report><Series><Services><Suicidal thoughts><Suicide><Symptoms><Teen><Teenagers><Testing><Thinking><Time><Treatment Day Care><Work><Youth><Youth 10-21><active followup><age 11 years><age group><associated symptom><behavior outcome><behavioral assessment><behavioral outcome><bio-markers><biologic marker><biomarker><clinical practice><co-morbid symptom><co-occuring symptom><cognitive capacity><comorbid symptom><concurrent symptom><cooccuring symptom><critical period><design><designing><developmental><disease onset><disorder onset><diverse populations><eleven year old><eleven years of age><emotion regulation><emotional regulation><experience><fatal attempt><fatal suicide><follow up><follow-up><followed up><followup><heavy metal Pb><heavy metal lead><heterogeneous population><high risk group><high risk individual><high risk people><high risk population><improved><informant><innovate><innovation><innovative><intent to die><kids><medical college><medical schools><mental illness><multi-modality><multimodality><parent><population diversity><pre-adolescent><preadolescence><preteen><protective factors><psychiatric care><psychiatric illness><psychiatric therapy><psychiatric treatment><psychological disorder><recruit><resilience><resilient><school of medicine><suicidal behavior><suicidal ideation><suicidal thinking><suicide behavior><suicide ideation><suicides><symptom association><symptom comorbidity><symptomatology><teen years><teenage><thoughts><thoughts about suicide><youngster>