Temple Strategies to Innovate EmeRgENcy Care Clinical Trials Network (Temple-SIREN)

Document text

Principal Investigator: NINA T GENTILE
Organization: TEMPLE UNIV OF THE COMMONWEALTH
Fiscal Year: 2024
Award: $383,128
Funding agency: National Institute of Neurological Disorders and Stroke

The Temple-led Emergency care research network (Temple-SIREN) is comprised of multiple community and academic medical centers and EMS providers throughout Philadelphia, New Jersey, Delaware, and Maryland to execute SIREN emergency care trials. To meet the needs for specific study enrollment, Temple-SIREN engaged the highest volume emergency and trauma centers and the busiest EMS systems in the region. This large hub-spoke network serves very diverse populations in densely populated cities as well as highly affluent suburban areas to rural regions of Bucks and Berks counties in PA Dutch country.  Temple-SIREN Hub and spoke leaders are committed to emergency care research and are active in trials of acute cardiopulmonary and neurological illness and traumatic brain injury trials. Through collaboration and hub oversight, the Temple-SIREN group expects to significantly contribute SIREN studies' enrollment. In addition, we plan to stay ahead of the curve by translating preclinical work to the bedside and using our highly diverse regional network for studies that needs of our diverse communities.  The Temple-SIREN Hub staff will work closely with participating site investigators and coordinators from multiple disciplines to efficiently execute SIREN studies. Mechanisms to enhance efficiency and quality of clinical research across sites include use of a common informatics system to identify potential study patients; frequent communication with investigators and coordinators via webinars and conference calls; diligent site management focused on good clinical research practices and compliance, and regular Hub-spoke meetings to provide additional training by study role. Temple-SIREN investigators and coordinators will participate in SIREN clinical coordinating center and data management center and ad hoc working groups to develop SIREN studies. The Temple-SIREN Hub team would benefit from participating in this coordinated approach to emergency care research as would the people of Philadelphia and the surrounding communities served by our hospitals and EMS systems.

Terms: <0-11 years old><21+ years old><Academic Medical Centers><Accident and Emergency department><Acute><Ad vector><Address><Adenoviral Vector><Adenovirus Vector><Adherence><Adult><Adult Human><African American><Afro American><Afroamerican><Agreement><Area><Award><Baltimore><Brain Trauma><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 prevention><COVID-19 public health crisis><COVID-19 years><CV-19><Cardiac><Cardiopulmonary><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Circulatory Collapse><Cities><Clinical><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Network><Collaborations><Communication><Communities><Coronavirus Infectious Disease 2019><Country><County><Data Coordinating Center><Data Coordination Center><Death><Delaware><Development and Research><Discipline><ED care><ER care><Education><Educational aspects><Emergencies><Emergency Care><Emergency Department><Emergency Department care><Emergency Medicine><Emergency Room care><Emergency Situation><Emergency care research><Emergency health care><Emergency healthcare><Emergency medical care><Emergency research><Emergency room><Emotional><Enrollment><Ethnic Origin><Ethnicity><Evaluation><Faculty><Fellowship><Financial cost><Fostering><Funding><Future><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Grant><Health Policy><Health Services><Health system><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Hospital Departments><Hospitals><Individuals from minority><Individuals of minority><Informatics><Injury><Institution><Investigators><Language><Leadership><Lung><Lung Respiratory System><Maryland><Medicine><Minority Groups><Minority People><Minority Population><Minority individual><NIH><National Institutes of Health><Neurologic><Neurological><Neurology><New Jersey><New York><Nursing Services><Outcome><Patient Care><Patient Care Delivery><Patients><Pennsylvania><Persons><Philadelphia><Population Heterogeneity><Pre-hospital setting><Prehospital setting><Process><Productivity><Protocol><Protocols documentation><Provider><R & D><R&D><Race><Races><Research><Research Design><Research Infrastructure><Research Personnel><Research Support><Researchers><Rewards><Role><Route><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shock><Site><Societies><Socio-economic status><Socioeconomic Status><Structure><Study Type><System><Time><Training><Translating><Trauma><Traumatic Brain Injury><United States National Institutes of Health><Universities><University Hospitals><University Medical Centers><Work><acute care><adeno vector><adenovector><adulthood><care for patients><care of patients><caring for patients><circulatory shock><clinical practice><conference><convention><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 prevention><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 prevention><coronavirus infectious disease-19><data management and coordinating center><data management center><disability><diverse populations><enroll><geographic site><health care policy><healthcare policy><heterogeneous population><improved><injured><injuries><innovate><innovation><innovative><kids><meeting><meetings><member><minority patient><monetary cost><multidisciplinary><operation><operations><participant enrollment><patient enrollment><patients from minority><patients of minority><payment><pediatric><population diversity><pre-clinical><preclinical><prevent COVID-19><prevent coronavirus disease 2019><pulmonary><racial><racial background><racial origin><research and development><rural area><rural location><rural region><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><shocks><social><social role><socio-economic position><socioeconomic position><study design><suburb><suburban><suburbia><summit><surveillance study><symposia><symposium><synergism><trauma centers><traumatic brain damage><trial enrollment><vaccination study><vaccination trial><vaccine study><vaccine trial><webinar><work group><working group><youngster>