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Principal Investigator: Guowei Wei
Organization: MICHIGAN STATE UNIVERSITY
Fiscal Year: 2023
Award: $541,935
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary
Due to massive vaccination, coronavirus disease 2019 (COVID-19) pandemic caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been partially under control.
However, emerging contagious variants such as Delta are still fueling new waves of infections
around the world. Vaccine-escape (or vaccine-breakthrough) variants pose renewed threats to
our battle against COVID-19. Understanding viral mutagenesis and evolution is of preeminent
importance. By integrating genomic analysis, artificial intelligence (AI), computational biophysics,
advanced mathematics, and experimental data, the PIs have built a comprehensive program with
the experimental level of accuracy and population-level of reliability for predicting SARS-CoV-2
variant infectivity and antibody disruption. It remains challenging to forecast future emerging
vaccine-escape variants, to develop the next-generation of vaccines, and to design mutation-
proof antibody therapeutics. These challenges are tackled in the proposed project. New
mathematical tools and AI algorithms will be developed to further improve the current state-of-
the-art in predicting mutation-induced viral infectivity changes, vaccine breakthroughs, and
antibody disruptions. Vital mutations in future emerging variants will be forecasted based on
molecular mechanisms, natural selection, and evolutionary effects. New mutation-proof antibody
drugs will be designed and tested based on those antibodies that had gone through earlier clinical
trials. The predictive models will be implemented into a user-friendly platform with online servers
for researchers to design mutation-proof new vaccines and antibody therapies. The proposed
methods will be applied to forecast emerging variants in the flu and improve the efficacy of
seasonal flu vaccines.
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