Development of the golden Syrian hamster model of COVID-19
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Principal Investigator: Connie Schmaljohn Organization: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES Fiscal Year: 2021 Award: $1,042,606 Funding agency: National Institute of Allergy and Infectious Diseases The IRF evaluated the disease progression after intranasal SARS-CoV-2 exposure in young (56 weeks old), aged (60week-old) wild-type (WT) golden Syrian hamsters, and adult (1422 weeks old) hamsters expressing the human ACE2 (hACE2) receptor. Disease was characterized by clinical observations along with virological, histopathological, and radiological assessments. Virus-exposed young and aged WT hamsters developed moderate to severe interstitial pneumonia, which reflects different aspects of human disease. Aged subjects demonstrated more severe disease than younger ones with more weight loss, increased lung pathology and abnormal imaging findings. Infection was uniformly lethal in adult hACE2 hamsters, most likely due to the neurological disease which is evident by histopathology and imaging. The hACE2 hamster model is not considered to be a model representative of human disease as lung disease is mild. PET with CT was successfully incorporated in these studies and indicated further support of the WT hamster model for pre-clinical countermeasure screening. Terms: <21+ years old><65+ years old><ACE2><Adult><Adult Human><Aged 65 and Over><Body Weight decreased><CAT scan><COVID-19><COVID19><CT X Ray><CT Xray><CT imaging><CT scan><CV-19><CV19><Clinical><Computed Tomography><Cricetinae><Development><Disease><Disease Progression><Disorder><General Radiology><Golden Hamsters><Golden Syrian Hamsters><Hamsters><Hamsters Mammals><Histopathology><Human><Image><Infection><Interstitial Lung Inflammation><Interstitial Pneumonia><Interstitial Pneumonitis><Interstitial Pulmonary Inflammation><Lung diseases><MR Imaging><MR Tomography><MRI><Magnetic Resonance Imaging><Medical Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mesocricetus auratus><Modeling><Modern Man><NMR Imaging><NMR Tomography><Nervous System Diseases><Neurologic Disorders><Neurological Disorders><Nuclear Magnetic Resonance Imaging><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathogenesis><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Pre-Clinical Model><Preclinical Models><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Pathology><Rad.-PET><Radiology><Radiology Specialty><Receptor Protein><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><SARS-CoV-2 exposure><SARS-CoV2 exposure><Severe acute respiratory syndrome coronavirus 2 exposure><Syrian Hamsters><Testing><Tomodensitometry><Virus><Weight Loss><Weight Reduction><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><adulthood><age 65 and greater><age 65 and older><aged><aged 65 and greater><aged ≥65><angiotensin converting enzyme 2><angiotensin converting enzyme II><body weight loss><catscan><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><corona virus disease 2019><coronavirus disease 2019><developmental><disease of the lung><disorder of the lung><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><human disease><human old age (65+)><imaging><lung disorder><lung pathology><nervous system disorder><neurological disease><old age><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><receptor><screening><temporal measurement><temporal resolution><time measurement><virology><wt-loss>