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Principal Investigator: Samuel Arbes
Organization: RHO FEDERAL SYSTEMS DIVISION, INC.
Fiscal Year: 2020
Award: $10,601,507
Funding agency: National Institute of Allergy and Infectious Diseases
PROJECT SUMMARY / ABSTRACT
COVID-19, the infectious disease caused by SARS-CoV-2, is rapidly affecting humans around the globe.
While initial epidemiological data have focused on cases that resulted in severe respiratory disease seen
predominantly in adults, little information regarding the infection burden in children is available. This is
complicated by the observation that many virologically confirmed cases in children are asymptomatic (Dong et
al, Pediatrics, PMID 32179660). Undocumented, and likely infectious, cases could result in exposure to a far
greater proportion of the community than would otherwise occur. Indeed, it has been proposed that
undocumented (or silent) infections are the source for almost 80% of documented infections (Li et al, Science,
PMID 32179701); thus, it is critical to determine the silent and symptomatic infection rate in children.
The purpose of this project is to develop, implement, and report on a surveillance study that will enroll and
prospectively observe eligible children who are current participants in NIH/NIAID/DAIT-funded pediatric
research studies and their family members. Many of these studies are focused on populations of children with
asthma or other atopic conditions. The primary objective of this study will be to determine the incidence of
SARS-CoV-2 infection (detection of virus in nasal secretions and stool and antibodies to the virus in blood)
over time in children and their household contacts (caregivers and siblings).
Terms: <0-11 years old><2019 novel coronavirus><2019-nCoV><21+ years old><Adult><Adult Human><Affect><Agreement><Antibodies><Asthma><Blood><Blood Reticuloendothelial System><Bronchial Asthma><COVID-19><COVID19><Care Givers><Caregivers><Child><Child Youth><Children (0-21)><Clinic><Clinical><Collection><Communicable Diseases><Communities><Cyclicity><Data><Data Bases><Data Collection><Data Reporting><Databases><Enrollment><Ensure><Epidemiological data><Epidemiology data><Event><Exposure to><Family member><Feces><Fee-for-Service Plans><Fees for Service><Funding><Household><Human><Incidence><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Investigators><Laboratories><Logistics><Lung diseases><Methods><Modern Man><Monitor><NIAID><NIH><Nasal><Nasal Passages Nose><National Institute of Allergy and Infectious Disease><National Institutes of Health><Nose><Participant><Pediatric Research><Pediatrics><Performance><Periodicity><Population><Principal Investigator><Protocol><Protocols documentation><Publications><Pulmonary Diseases><Pulmonary Disorder><Reporting><Research Design><Research Personnel><Researchers><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Respiratory System, Nose, Nasal Passages><Rhythmicity><Role><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Safety><Science><Scientific Publication><Services><Severe acute respiratory syndrome coronavirus 2><Siblings><Source><Study Type><System><Time><Transmission><United States National Institutes of Health><Universities><Vendor><Virus><Work><Wuhan coronavirus><adulthood><burden of infection><children><childrens'><corona virus disease 2019><coronavirus disease 2019><data base><data management><data quality><data representation><disease of the lung><disorder of the lung><enroll><epidemiologic data><indexing><infection burden><infection rate><lung disorder><prospective><rate of infection><research study><rho><social role><sound><stool><study design><surveillance study><transmission process><viral detection><virology><virus detection><youngster>