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Principal Investigator: JOHN J FOXE
Organization: UNIVERSITY OF ROCHESTER
Fiscal Year: 2022
Award: $213,402
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
ABSTRACT
School-children with intellectual and developmental disabilities (IDD) are at acute risk for severe COVID-19.
Many have compromised immunological and respiratory function, cognitive impairment and complex medical
issues. Children with IDD desperately need to attend specialized schools, but this also places them at ultra-high
risk of COVID-19 exposure and infection, despite masking, distancing, and vaccination of staff. Critically, we
lack longitudinal data on development and persistence of antibody-mediated immunity to COVID-19 for children
and staff in IDD-specialized schools, including cross-strain protection, to guide development of vaccination and
policy recommendations. This supplement brings together the strengths of the University of Rochester
Intellectual and Developmental Disabilities Center and the UR RADx-UP. Under this Administrative
Supplement, we propose continuation of our prospective, longitudinal tracking of anti-SARS-CoV-2 antibodies
in over 56 IDD students and 282 staff at a specialized school for IDD children. Via RADx-UP, we currently have
7 monthly capillary blood samples per subject analyzed for anti-spike (S) and anti-nucleoprotein (N) IgG against
SARS-CoV-2 and variants, and common coronavirus strains (HCoVs: OC43, HKU1, NL63, 229E) measured
by the mPLEX-CoV research assay. We will extend this prospective, longitudinal study with an additional 12
months of sampling to capture increases and decreases in SARS-CoV-2 antibody levels. In Aim 1 we will use
multidimensional measurement of anti-SARS-CoV-2 and other coronavirus antibodies over 1 year to estimate
the rate at which antibodies decrease after vaccination and infection. We will use memory B cell studies to
estimate long-lived immune memory and multidimensional analysis of IgG immune repertoire against SARS-
CoV-2 variants. In Aim 2, we will link these data, with a comprehensive immune response genotypic and IDD
phenotypic analysis. Targeted resequencing of vaccine response genes will provide critical information on
immune response associated gene mutations (e.g. cytokine promoter polymorphisms) in neurotypical staff and
IDD children, and their influence on anti-SARS-CoV-2 antibody levels. Successful completion of this project
will identify decay rates of anti-SARS-CoV-2 IgG in vaccinated subjects, and provide new data on association
of IDD phenotyping and immune gene SNPs with vaccine responses.
Terms: <0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV vaccine><2019-nCoV variant><2019-nCoV variant forms><2019-nCoV variant strains><21+ years old><7S Gamma Globulin><Ab-mediated immunity><Ab-mediated protection><Acute><Administrative Supplement><Adoption><Adult><Adult Human><Antibodies><Antibody immunity><Antibody protection><Antibody-mediated protection><Assay><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Binding><Bioassay><Biologic Assays><Biological Assay><Blood Sample><Blood Serum><Blood capillaries><Blood specimen><COVID-19><COVID-19 antibody><COVID-19 exposure><COVID-19 immunity><COVID-19 infection><COVID-19 vaccine><COVID-19 variant><COVID-19 variant forms><COVID-19 variant strains><COVID-19 virus><COVID19><COVID19 immunity><COVID19 infection><COVID19 vaccine><COVID19 virus><CV-19><CV19><Caring><Cellular Immune Function><Child><Child Development Disorders><Child Youth><Children (0-21)><Clinical 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disability><Intellectual limitation><Intellectual scale><Intervention><Intervention Strategies><Ir Gene><Language><Link><Longitudinal Studies><MRDD Research Center><MRDDRC><Masks><Measurement><Measures><Mediating><Medical><Medical History><Memory B Cell><Memory B-Lymphocyte><Mental Retardation and Developmental Disabilities Research Centers><Modeling><Modern Man><Molecular Interaction><Nucleoproteins><Nutritional><Outcome><Parents><Participant><Patient Self-Report><Personal Medical History><Personal Medical History Epidemiology><Phenotype><Prevent infection><Preventative measure><Preventative strategy><Prevention strategy><Preventive measure><Preventive strategy><Protocol><Protocols documentation><RADx><RADx Underserved Populations><RADx-UP><RNA vaccine><RNA-based vaccine><Rapid Acceleration of Diagnostics><Rapid Acceleration of Diagnostics Underserved Populations><Research><Respiratory physiology><Risk><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 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