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Principal Investigator: Robert Hal Scofield
Organization: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Fiscal Year: 2024
Award: $636,668
Funding agency: National Institute of General Medical Sciences
Although some improvement has been made since the Oklahoma Shared Clinical and Translational Resources
(OSCTR) initiation, Oklahoma remains consistently in or near the bottom 10% of states for the overall health of
its population. Oklahoma’s residents disproportionately suffer from chronic health problems, such as obesity,
diabetes, cardiovascular disease, and arthritis/autoimmunity. Oklahomans have a life expectancy of 4 years
shorter than the average US citizen, while American Indians have a life expectancy of more than 7 years
shorter than other groups within the US. With high percentages of rural (34%) and tribal (16%) populations,
Oklahoma has unique challenges and opportunities to implement clinical and translational research (CTR)
projects and dissemination and implementation research to improve health and disease outcomes. The Clinical
Resources (ClinRes) Core of the OSCTR has built a centralized system to support human subjects research
focused on these issues. The Core provides clinical research facilities and staff to assist with participant
recruitment and regulatory approvals, a CAP-certified Biorepository that has allowed the OSCTR to adopt or
establish registries, repositories, and cohorts to assist investigators in obtaining and utilizing high-quality
samples to support their research efforts, and infrastructure for accessing de-identified patient data to support
clinical research projects. These efforts have allowed the Core to support the careers of multiple CTR
investigators, including researchers who are members of the under-represented minority communities in the
state. The ClinRes Core will continue to provide this invaluable access to sample collections while supporting
the establishment and growth of new repositories focusing on the health issues of greatest concern to our
populations, including cancer, diabetes, and arthritis. The ClinRes core will continue to work with the
Community Engagement and Outreach (CEO) Core to build on the strong relationships developed with smaller
community organizations across the state during the COVID-19 pandemic. Together, these collaborations
enhance the overall opportunities of our CTR investigators to expand clinical study and trial access to residents
throughout the state to help increase participant diversity and address our rural and minority health disparities.
The ClinRes Core will continue to provide junior investigators with essential assistance with institutional IRB
applications, protocols, data safety monitoring boards, and other regulatory requirements and will work with the
Administrative Core to make access to resources and information more accessible to investigators, clinicians,
clinical research staff, and participants through the Gateway to Oklahoma portal. With the CEO Tribal
Engagement Unit, we will assist investigators in working with the Indian Health Service and tribal IRBs,
ensuring the protection of both individual human subjects and tribal community populations. Finally, we will
continue developing and supporting resources to grow our clinical research informatics capacity to facilitate
local and national research efforts.
Terms: <2019-nCoV vaccine><Acceleration><Address><Adopted><American Indian><American Indians><Area><Arthritis><Autoimmune Status><Autoimmunity><Basic Research><Basic Science><COBRE><COVID crisis><COVID epidemic><COVID pandemic><COVID testing><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 testing><COVID-19 therapeutics><COVID-19 vaccine><COVID-19 years><COVID19 testing><CV-19><Cancers><Cardiovascular Diseases><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Center of Biomedical Research Excellence><Centers of Research Excellence><Certification><Cherokee Nation><Child Health><Childhood><Chronic><Clinical><Clinical Data><Clinical Informatics><Clinical Investigator><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Data Monitoring Committees><Clinical Trials Network><Collaborations><Community Outreach><Contract Services><Contracting Opportunities><Contracts><Coronavirus Infectious Disease 2019><Data><Data Analyses><Data Analysis><Data Bases><Data Monitoring Committees><Data and Safety Monitoring Boards><Databases><Degenerative Arthritis><Degenerative polyarthritis><Development><Diabetes Mellitus><Disease><Disease Outcome><Disorder><Dissemination and Implementation><Effectiveness><Ensure><Feasibility Studies><Funding><Generalized Growth><Growth><Health><Human Resources><Human Subject Research><IRB><IRBs><Indian Health Service><Individual><Individuals from minority><Individuals of minority><Informatics><Infrastructure><Inpatients><Institution><Institutional Review Boards><Investigation><Investigators><Investments><K-Awards><K-Series Research Career Programs><Learning><Life Expectancy><Malignant Neoplasms><Malignant Tumor><Manpower><Mediation><Medical><Mentors><Minority Groups><Minority People><Minority Population><Minority individual><NARCH><NCATS><NIH><National Center for Advancing Translational Sciences><National Institutes of Health><Native American Research Center for Health><Negotiating><Negotiation><Obesity><Oklahoma><Osteoarthritis><Osteoarthrosis><Outcome><PASC><Participant><Patient Recruitments><Patients><Phase><Play><Population><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Process><Protocol><Protocols documentation><R-Series Research Projects><R01 Mechanism><R01 Program><RADx Underserved Populations><RADx-UP><Rapid Acceleration in Diagnostics for Underserved Populations><Rapid Acceleration of Diagnostics Underrepresented Persons><Rapid Acceleration of Diagnostics Underserved Populations><Registries><Reproducibility><Research><Research Activity><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Role><Rural><Rural Minority><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV-2 testing><SARS-CoV-2 therapeutics><SARS-CoV-2 vaccine><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-coronavirus-2 therapeutics><SARS-coronavirus-2 vaccine><Safety Monitoring Boards><Sampling><Scientist><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome coronavirus 2 therapeutics><Severe acute respiratory syndrome coronavirus 2 vaccine><Site><System><Therapeutic Intervention><Tissue Growth><Translational Research><Translational Science><Tribes><Underrepresented Ethnic Minority><Underrepresented Minority><United States Indian Health Service><United States National Institutes of Health><Variant><Variation><Viral><West Virginia><Work><adiposity><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><arthritic><biobank><biorepository><cardiovascular disorder><career><chronic COVID-19 sequelae><clinical infrastructure><cohort><community based organizations><community engagement><community organizations><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 testing><coronavirus disease 2019 therapeutics><coronavirus disease 2019 vaccine><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease testing><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 vaccine><coronavirus infectious disease-19><coronavirus testing><corpulence><data base><data interpretation><data warehouse><degenerative joint disease><depository><developmental><diabetes><engagement with communities><hesitant to vaccination><human subject><hypertrophic arthritis><implementation research><improved><informatics infrastructure><innovate><innovation><innovative><intervention therapy><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><malignancy><member><minority communities><minority health disparity><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><neoplasm/cancer><new growth><ontogeny><osteoarthritic><participant recruitment><pediatric><personnel><population health><post COVID-19 sequelae><post acute sequelae following COVID-19><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><programs><recruit><repository><research facility><response><rural health disparities><sample collection><satisfaction><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 testing><social role><specimen collection><testing for COVID><testing of COVID><therapeutic vaccine><therapeutics against COVID-19><therapeutics against SARS-CoV-2><therapeutics against SARS-coronavirus-2><therapeutics against Severe acute respiratory syndrome coronavirus 2><therapeutics against coronavirus disease 2019><therapeutics for novel coronavirus><translation research><translational investigation><translational investigator><translational researcher><translational scientist><treatment vaccines><tribal community><under-representation of minorities><under-represented minority><underrepresentation of minorities><vaccination hesitancy><vaccine against 2019-nCov><vaccine against COVID-19><vaccine against SARS-CoV-2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine candidates against SARS-CoV-2><vaccine for novel coronavirus><vaccine for the treatment><vaccine for treatment><vaccine hesitancy><vaccine hesitant><vaccines preventing COVID><vaccines to prevent COVID>