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Principal Investigator: Benjamin Goldman-Israelow
Organization: YALE UNIVERSITY
Fiscal Year: 2024
Award: $193,828
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary/Abstract
To date, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) has caused over 32 million
cases of coronavirus disease (COVID-19), with ~1 million associated deaths. Multiple vaccine trials have
begun in an effort to stop this pandemic, yet the correlates of viral clearance and immune protection from
SARS-CoV-2 remain unknown. In fact, there are no licensed vaccines to any human coronavirus, as we have
not yet discovered the immunologic correlates of a successful coronavirus vaccine. In his brief tenure in the
Iwasaki lab, Dr. Goldman-Israelow has already developed a highly adaptable mouse model of SARS-CoV-2
infection that can be applied to mice of any genotype. He published this work as co-first author in the Journal of
Experimental Medicine. He also showed that innate immune activation drives acute pathology. However, the
extent to which innate immune signals drive adaptive immunity remains to be explored. This proposal will
address how: (1) type I interferon signaling and (2) cGAS signaling control antibody development to SARS-
CoV-2. This work is critical for characterizing the fundamental rules that govern adaptive immunity to SARS-
CoV-2, which will promote the development of highly effective vaccines.
This proposal describes a rigorous five-year career development training program for Benjamin Goldman-
Israelow, M.D., Ph.D., with the goal of preparing him for an independent research career as an academic
physician-scientist. The principal investigator is a physician scientist who completed his M.D. and Ph.D.
training in Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, where he studied molecular
virology. Dr. Goldman-Israelow continued his training by joining the Physician Scientist Research Pathway at
Yale New Haven Hospital, a combined residency and fellowship program, and is currently an infectious
diseases fellow. He has embarked on an intensive training program to broaden his expertise in viral
immunology under the mentorship of Dr. Akiko Iwasaki, a pioneer and world leader in deciphering the complex
interplay among viruses, innate immune recognition, and adaptive immunity. Dr. Iwasaki is not only a world-
class scientist, but also a world-class mentor with a very productive track record of mentoring physician-
scientists. In addition to the intellectual grooming and practical laboratory-based training that Dr. Goldman-
Israelow will continue to receive in Dr. Iwasaki’s lab, he has developed a training program built on high-yield
didactic coursework. He has also carefully crafted an advisory committee comprising translational scientists
with a broad range of scientific expertise relevant to this proposal and impressive records of mentorship. Yale
School of Medicine, along with its Departments of Internal Medicine and Immunobiology, will provide the
resources, support, and infrastructure to assist Dr. Goldman-Israelow in achieving the aims described in this
proposal and his long-term goal of developing into an independent physician-scientist studying the rules that
govern antibody development to both viral infection and vaccination.
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