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Principal Investigator: DEAN R MADDEN
Organization: DARTMOUTH COLLEGE
Fiscal Year: 2024
Award: $2,460,000
Funding agency: National Institute of General Medical Sciences
The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a
sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most
fundamental research. At the same time, it helps orient mechanistic investigations towards long-term
translational goals for complex diseases such as cancer and infections. In phase I, our progress was strong.
All six of our research project leaders (RPL) with more than two years’ support have received R01-equivalent
funding. Our cores provide unique protein biochemistry resources and ‘navigators’ to access microscopes
campus-wide. Our cores and seminars have created a vibrant and interdisciplinary community. Here, we
propose to deploy phase II COBRE and institutional program enrichment funds to build on this foundation and
fill key gaps to prepare bioMT for the transition to sustainable COBRE independence. Aim 1 is to increase our
cohort of funded bioMT investigators to fill strategic roles in our research landscape. Our two most recent
RPLs (3–15 months’ support) are continuing into phase II, joined by two outstanding new hires. Their projects
explore basic signaling and immunological mechanisms with potential relevance to therapeutic targets ranging
from respiratory infections to cancer progression and metastasis, interconnected by shared scientific and
technical interests. All receive guidance from dedicated mentoring dyads to assist in career advancement and
independent extramural funding, and all receive support from responsive scientific cores offering state-of-the-
art technologies directly relevant to their bioMT research projects. With institutional support, we will also hire
five new faculty members, aligned with our theme of discovering and exploiting molecular targets, and
selected to enhance thematic subgroups. As starting RPLs graduate, we will recruit new hires and other
potential candidates for EAC consideration as replacements. Aim 2 is to enhance our core facilities and
prepare them for a transition to COBRE independence during phase III. The cores are fully staffed and have
invested heavily in phase I instrumentation. We will partner to add key new technologies based on user input,
including parallel protein expression, mass spectrometry, advanced microscopy, and cryoEM. Cost-recovery
models will be developed for incremental deployment in phase III to enable core financial independence. Aim
3 continues enriching our community, including mini-symposia and pilot awards to foster new multi-PI and
program-project applications, which will contribute to core sustainability. Overall, these aims will leverage
proven COBRE strategies – junior faculty hiring, extramural and academic mentoring, excellent administrative
and scientific core support, and interdisciplinary community building – to enhance bioMT’s scientific impact in
targeted areas of need. This will prepare us for the transition to phase III funding and ultimate independence
as an interdisciplinary and nationally visible research institute, spanning three schools and 10 departments at
Dartmouth and deeply connected to local centers and regional IDeA partners.
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