Modulation of chronic inflammatory responses by COVID19

NIH Pandemic-Era Grants

Pandemic Era Grants

2024

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Principal Investigator: Mariana  Kaplan
Organization: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
Fiscal Year: 2024
Award: $299,397
Funding agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases

We are close to finalizing the last visits for this study and analysis is ongoing.   The study enrolled patients with a variety of autoimmune diseases including Systemic Lupus Erythematosus, Rheumatoid Arthritis, Idiopathic Inflammatory Myopathies, Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis, Sjogren, Scleroderma, as well as patients with immune mediated kidney disease and healthy controls. We plan to finalize a variety of statistical analyses to assess association with clinical features (actively being collected) in response to both vaccine and infection. Multiomics analysis is being finalized.

Terms: <2019-nCoV vaccine><ANCA associated vasculitis><ANCA vasculitis><Anti-neutrophil cytoplasmic antibody associated vasculitis><Anti-neutrophil cytoplasmic antibody related vasculitis><Anti-neutrophil cytoplasmic antibody vasculitis><Anti-neutrophil cytoplasmic antigen induced vasculitis><Anti-neutrophil cytoplasmic autoantibody associated vasculitis><Anti-neutrophil cytoplasmic autoantibody vasculitis><Atrophic Arthritis><Autoantibodies><Autoimmune Diseases><Autoimmune Responses><Autoimmune Status><Autoimmunity><Blood Vessels><COVID-19><COVID-19 exposure><COVID-19 infection><COVID-19 vaccine><COVID-19 virus infection><COVID19 infection><CV-19><Chronic><Clinical><Coronavirus Infectious Disease 2019><Diagnosis><Exposure to><Idiopathic Inflammatory Myopathies><Immune><Immunes><Immunomodulation><Individual><Infection><Inflammation><Inflammatory Response><Kidney Diseases><Lupus Erythematosus Disseminatus><Mediating><Nephropathy><Patients><Phenotype><Renal Disease><Rheumatoid Arthritis><SARS-CoV-2 exposure><SARS-CoV-2 infection><SARS-CoV-2 vaccine><SARS-CoV2 exposure><SARS-CoV2 infection><SARS-coronavirus-2 vaccine><SLE><Scleroderma><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe acute respiratory syndrome coronavirus 2 exposure><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 vaccine><Sicca Syndrome><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Vaccination><Vaccines><Visit><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive antibody><coronavirus disease 2019><coronavirus disease 2019 exposure><coronavirus disease 2019 infection><coronavirus disease 2019 vaccine><coronavirus disease-19><coronavirus disease-19 vaccine><coronavirus infectious disease-19><dermatosclerosis><disseminated lupus erythematosus><exposure to COVID-19><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><exposure to coronavirus disease 2019><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><kidney disorder><multiomics><multiple omics><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><pandemic><pandemic disease><panomics><participant enrollment><patient enrollment><renal disorder><response><rheumatic arthritis><self reactive antibody><statistical analysis><systemic autoimmunity><systemic lupus erythematosis><vaccine against 2019-nCov><vaccine against COVID-19><vaccine against SARS-CoV-2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine candidates against SARS-CoV-2><vaccine for novel coronavirus><vaccines preventing COVID><vaccines to prevent COVID><vascular><xerodermosteosis>