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Principal Investigator: BRYAN O BUCHHOLZ
Organization: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Fiscal Year: 2024
Award: $1,732,375
Funding agency: National Heart Lung and Blood Institute
Project Summary/Abstract – Overall Core
American healthcare is rapidly evolving to a state where efficiency, quality and patient satisfaction are dominant
drivers. Several trends are driving fundamental changes in health care: 1) an expanding scope of virtual care
and telemedicine, accelerated by the COVID-19 pandemic, has changed how patients, healthcare providers,
and health systems interact; 2) a growing recognition of disparities leading to an emphasis in providing healthcare
equitably for historically marginalized populations; 3) an increasing appreciation for the patient as a critical
stakeholder in therapeutic decision-making, leading to an emphasis on patient-centered design; and 4)
increasing access to home health to enable better diagnosis, prevention and management of health conditions,
as illustrated by widespread adoption of home-testing for SARS-CoV-2. Despite this rapidly changing
environment, heart (cardiovascular), lung, blood, and sleep disorders (HLBS) continue to cause significant
morbidity, mortality, and cost in the US and worldwide. Combined, these diseases account for 41% of deaths in
the US and lead to over $400B in direct health care expenses plus lost income to affected patients and
caregivers. Thus, there are urgent unmet needs in HLBS. We will address these issues with the renewal of the
Center for Advancing Point of Care Technologies (CAPCaT) in HLBS Disorders. CAPCaT is a highly successful
Point-of-Care Technology Research Network (POCTRN) Center that leverages our experience running a
medical product incubator, the Massachusetts Medical Device Development Center (M2D2) at the University of
Massachusetts (Lowell and Worcester campuses), and our experience administering grants, running, and
managing solicitations, and working 1:1 with awardees to advance their technologies toward commercialization.
CAPCaT expanded upon the original vision and success of M2D2 and now has its own established track record
and collaborative network to develop and optimize novel POC and home-based technologies to improve the
diagnosis and management of HLBS disorders. Our objectives in achieving this goal are to continue: 1)
identifying, through stakeholder engagement, the most promising POC and home-based technologies to address
unmet medical needs; 2) supporting developmental plans, including pathways to adoption at the point of care or
in the home; and 3) training and disseminating developing POC and home-based technologies to the different
stakeholders.
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disease rate><NIH><National Institutes of Health><Needs Assessment><Outcome><Patents><Pathway interactions><Patient Satisfaction><Patients><Point of Care Technology><Policy Maker><Population Heterogeneity><Prevention><Process><Provider><Pulmonary Diseases><Pulmonary Disorder><QOC><Quality of Care><Research><Research Personnel><Research Resources><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Risk><Running><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV-2 testing><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Salutogenesis><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sight><Sleep><Sleep Disorders><System><Task Forces><Technology><Telemedicine><Therapeutic><Time><Training><Underserved Population><United States National Institutes of Health><Universities><Vision><Work><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><acute care><advisory team><blood disorder><circulatory system><clinical development><clinical test><commercialization><community engagement><community-based health><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 testing><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease testing><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus testing><cost><design><designing><developmental><device development><disease of the lung><disorder of the lung><diverse populations><driving><engagement with communities><evidence base><experience><health care><health care access><health care availability><health care management><health care personnel><health care quality><health care service access><health care service availability><health care worker><health equity><health management><health provider><health workforce><healthcare access><healthcare accessibility><healthcare availability><healthcare management><healthcare personnel><healthcare quality><healthcare service access><healthcare service availability><heart disorder><heterogeneous population><home test><home-based test><homes><improved><incomes><individualized management><individualized patient management><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><instrument development><lung disorder><marginalized group><marginalized individual><marginalized people><marginalized population><medical college><medical personnel><medical schools><mortality><new technology><novel><novel technologies><participant engagement><pathway><patient centered><patient engagement><patient oriented><personalized clinical management><personalized disease management><personalized management><point of care><population diversity><precision management><prevent><preventing><programs><promoting health><pulmonary><research clinical testing><school of medicine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 testing><sleep diseases><sleep dysfunction><sleep illness><sleep problem><success><technological research and development><technology research and development><testing for COVID><testing of COVID><tool><treatment provider><trend><trial design><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><virtual care><virtual health care><virtual healthcare><visual function>