Octpamine controls adaptation to endurance exercise in Drosophila
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Principal Investigator: Robert John Wessells Organization: WAYNE STATE UNIVERSITY Fiscal Year: 2024 Award: $441,380 Funding agency: National Institute on Aging Project Summary Endurance exercise is a highly effective intervention for ensuring healthy metabolism and maintaining healthy function during aging, but is unavailable to patients with illnesses or injuries that restrict their movement. Here, we follow up on previous discoveries from the fruit fly model system showing that stimulation of octopamine secretion from the brain acts through receptors in muscle and fat to coordinate benefits of exercise in sedentary animals. Here, we propose to identify genetic factors that mediate increased neuronal branching in the exercising brain (Aim 1), elucidate the pathway regulating the response to octopamine in exercising muscle (Aim 2), and by extending these results into humans for the first time using virtual reality stimulation to produce some benefits of exercise in sedentary humans (Aim 3). Terms: <Active Follow-up><Acute><Address><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Age><Aging><Animals><Automobile Driving><Autoregulation><Award><Biologic Models><Biological Models><Body Tissues><Brain><Brain Nervous System><Brain region><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Communication and Signaling><Cell Signaling><Chronic><Circulation><Development><Drosophila><Drosophila genus><Encephalon><Ensure><Exercise><Exposure to><Fats><Fatty acid glycerol esters><Flies><GeneHomolog><Genes><Genetic><Genetic analyses><Grant><Health><Heart Vascular><Homeostasis><Homolog><Homologous Gene><Homologue><Human><Incidence><Individual><Injury><Intermediary Metabolism><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Knowledge><Levarterenol><Levonorepinephrine><Mediating><Mediator><Metabolic><Metabolic Processes><Metabolism><Methods><Model System><Modeling><Moderate Exercise><Modern Man><Movement><Muscle><Muscle Tissue><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Noradrenaline><Norepinephrine><Norsympatol><Norsynephrine><Octopamine><Pathway interactions><Patients><Periodicals><Persons><Physiologic><Physiological><Physiological Homeostasis><Position><Positioning Attribute><Proteomics><Receptor Protein><Role><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Muscle><Stimulus><Therapeutic><Time><Tissues><Up-Regulation><Upregulation><Voluntary Muscle><Work><active followup><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><biological signal transduction><body movement><circulatory system><design><designing><determine efficacy><developmental><disabled><driving><effective intervention><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><endurance exercise><evaluate efficacy><examine efficacy><exercise capacity><exercise training><experience><fly><follow up><follow-up><followed up><followup><fruit fly><genetic analysis><health-span><healthspan><healthy life span><injured><injuries><interventional strategy><life-style factor><lifestyle factors><moderate physical activity><muscular><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><norsynephrine receptor><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><octopamine receptor><pathway><periodic><periodical><receptor><response><sedentary><simulated virtual reality><simulation><single molecule><social role><time use><tool><virtual reality><virtual reality simulation><virtual simulation>