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Principal Investigator: LOUISE CHANG LAURENT
Organization: GORDON RESEARCH CONFERENCES
Fiscal Year: 2023
Award: $10,000
Funding agency: National Cancer Institute
PROJECT SUMMARY
This R13 application requests partial funding to support the upcoming Gordon Research Conference (GRC) on
RNA Nanotechnology, which will be held in Ventura, CA on Jan 8-13, 2023, and the associated Gordon Research
Symposium (GRS), to precede it on Jan 7-8. The meeting will be co-chaired by Louise Laurent and Sarah
Woodson, who were elected at the second GRC on RNA Nanotechnology in January 2017 and served as the
co-vice chairs of the third GRC in January 2019. The conference planned for 2021 was postponed by the GRC
due to the COVID pandemic. RNA nanotechnology continues to grow as an important field, with active research
being carried out to elucidate basic principles of and develop innovative approaches to the design and
construction of a variety of RNA nanostructures, as well as exciting work applying RNA nanotechnology to solving
problems in biotechnology and medicine. The pace of discovery and innovation has only accelerated in the past
two years. RNA nanotechnology is built upon unique properties of RNA, including structural versatility, existing
biological functions, and ease of functionalization, which make it an ideal platform on which to build complex
self-assembling architectures with a variety of functional attributes for diverse applications. This GRC focuses
on linking fundamental studies on the mechanisms of RNA structure, assembly, and packaging to translational
work using RNA nanotechnology in imaging, diagnostics, and therapeutics.
The meeting will cover a range of topics in nine sessions. Sessions on RNA Modifications & Biotypes, RNA
Structure & Assembly, and Synthetic & Programmed Nucleic Acid Assemblies will feature cutting-edge research
on the molecular basis of nucleic acid architectures, design and characterization of nucleic acid nanostructures,
and biophysical approaches to study and predict RNA folding. Emerging new applications of nucleic acid
architectures as functional devices and as control elements in synthetic biology will be presented in sessions on
RNA Aptamers & Riboswitches and RNA Imaging. Sessions on RNA Encapsulation & Delivery, RNA Cargo
Selection in extracellular vesicles, RNA-based Biomarkers & Diagnostics, and RNA Therapeutics will provide
perspectives on discovery, isolation and application of RNA from extracellular vesicles and viruses with an
emphasis on translational aspects of natural and synthetic RNAs in development of diagnostics and therapeutics.
The 2023 conference will continue to emphasize robust representation of women and minority scientists. The
invited speakers and discussion leaders will include a mix of established researchers in the field and outstanding
junior-level investigators from around the world. The meeting will be advertised to a diverse audience to include
early career and under-represented minority scientists in the RNA nanotechnology and related fields. A Power
Hour will feature topics of inclusion and opportunity.
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diagnostics><computer biology><conference><convention><corona virus disease><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><design><design and construct><design and construction><designing><developmental><drug development><early detection><enthusiastic atmosphere><enthusiastic environment><extracellular><extracellular vesicles><fundamental research><graduate student><imaging><innovate><innovation><innovative><interdisciplinary collaboration><interest><mRNA vaccine><mRNA-based vaccine><medical diagnostic><meeting><meetings><metabolic engineering><minority scientist><nano tech><nano technology><nano-sized structures><nano-structures><nano-technological><nanotech><nanotechnological><new drug treatments><new drugs><new growth><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><noncoding><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><post-doc><post-doctoral><post-doctoral trainee><programs><rational design><research associates><screening><screenings><self assembly><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><success><summit><supportive atmosphere><supportive environment><symposia><symposium><synthetic biology><therapeutic RNA><transdisciplinary collaboration><translation strategy><translational applications><translational approach><translational opportunities><translational potential><translational strategy><under-representation of minorities><under-represented minority><undergrad><undergraduate><undergraduate student><underrepresentation of minorities>