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Principal Investigator: susmita chowdhuri
Organization: JOHN D DINGELL VA MEDICAL CENTER
Fiscal Year: 2024
Funding agency: Veterans Affairs
Patients recovering from acute COVID-19 infection often suffer from a multitude of debilitating chronic physical
symptoms that can last up to 6 months or more. The incidence of fatigue, cognitive impairment and respiratory
symptoms are reported to be very high in the post-COVID period. The underlying pathophysiology of cognitive
impairment is unclear in these patients. Notably, sleep disturbances are common during this post-COVID
period, and sleep apnea has been associated with an increased risk for severe COVID infection. Thus, it is
conceivable that sleep fragmentation, per se, may confer an increased risk for chronic cognitive deficits in
Veterans post-COVID. Our proposed pilot project will determine if there is a link between post-COVID sleep
disturbances, sleep apnea and cognitive function. Knowledge gained from our examinations may guide
development of novel management pathways, i.e., mitigation of sleep disturbances may present a therapeutic
strategy for alleviating chronic post-COVID cognitive impairment.
Aim1 will investigate the effect of sleep duration and sleep quality on neurocognitive function in post-COVID
Veterans. Aim 2 will study whether the severity of OSA determines neurocognitive function Veterans who are
post-COVID. This is an observational study where we will gather retrospective as well as prospective data on
the long-term effects of COVID on neurocognitive function and sleep. Our long-term goal is to enhance
rehabilitation and recovery of function of Veterans suffering from post-COVID consequences that may arise
due to sleep disturbances, with the ultimate objective of improving the overall health and quality of life of
Veterans recovering from COVID-19 infection.
Terms: <(TNF)-α><Acute><Adverse effects><Alleles><Allelomorphs><Alzheimer's disease patient><Alzheimer's patient><Apo-E><ApoE><ApoE protein><Apolipoprotein E><Area><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Blood Coagulation Disorders><Breathlessness><COVID crisis><COVID disease severity><COVID epidemic><COVID pandemic><COVID severity><COVID survivors><COVID-19><COVID-19 affected><COVID-19 associated cytokine storm><COVID-19 consequence><COVID-19 crisis><COVID-19 cytokine storm><COVID-19 disease severity><COVID-19 effect><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 impact><COVID-19 impacted><COVID-19 induced cytokine storm><COVID-19 induced neurocognitive dysfunction><COVID-19 infection><COVID-19 infection survivors><COVID-19 neurocognitive consequences><COVID-19 neurocognitive impacts><COVID-19 neurocognitive manifestations><COVID-19 neurocognitive sequelae><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 related cognitive decline><COVID-19 related cytokine storm><COVID-19 severity><COVID-19 survivors><COVID-19 virus infection><COVID-19 years><COVID19 disease severity><COVID19 infection><COVID19 severity><CV-19><Cachectin><Cephalalgia><Cephalgia><Cephalodynia><Chronic><Chronic disability><Clinical><Coagulation Disorder><Coagulopathy><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Complex><Coronavirus Infectious Disease 2019><Coughing><Cranial Pain><Data><Development><Diagnostic><Disease><Disorder><Disturbance in cognition><Dysfunction><Dyspnea><Encephalopathies><Fatigue><Functional disorder><Future><Genes><Goals><HPGF><Head Pain><Headache><Health><Healthcare><Hepatocyte-Stimulating Factor><Hour><Hybridoma Growth Factor><Hypoxia><Hypoxic><IFN-beta 2><IFNB2><IL-6><IL6 Protein><IQ Deficit><Impaired cognition><Impairment><Incidence><Infection><Inflammation><Interleukin-6><Knowledge><Lack of Energy><Link><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><MGI-2><Macrophage-Derived TNF><Medical Rehabilitation><Memory Deficit><Memory impairment><Mental Health><Mental Hygiene><Monocyte-Derived TNF><Myeloid Differentiation-Inducing Protein><Neurocognitive><Neurocognitive Deficit><Neurologic><Neurological><Neutrophilia><Observation research><Observation study><Observational Study><Observational research><Obstructive Sleep Apnea><Oxygen Deficiency><PASC><Pathway interactions><Patients><Persistent disability><Physiopathology><Pilot Projects><Plasmacytoma Growth Factor><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Psychological Health><QOL><Quality of life><Recovery><Recovery of Function><Rehabilitation><Rehabilitation therapy><Reporting><Research><Respiratory Signs and Symptoms><Risk><SARS-CoV-2 associated cytokine storm><SARS-CoV-2 cytokine storm><SARS-CoV-2 disease severity><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 induced cytokine storm><SARS-CoV-2 infection><SARS-CoV-2 neurocognitive sequelae><SARS-CoV-2 pandemic><SARS-CoV-2 related cytokine storm><SARS-CoV-2 severity><SARS-CoV-2 survivors><SARS-CoV2 infection><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severities><Sleep><Sleep Apnea><Sleep Apnea Syndromes><Sleep Deprivation><Sleep Fragmentations><Sleep Hypopnea><Sleep disturbances><Sleep-Disordered Breathing><Symptoms><Syndrome, Sleep Apnea, Obstructive><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Veterans><Virus><Visit><aberrant sleep><acute COVID-19><acute SARS-CoV-2 infection><acute infection><acute phase of COVID-19><acute phase of SARS-CoV-2 infection><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><airway symptom><bleeding disorder><brain fog><chronic COVID><chronic COVID-19><chronic COVID-19 sequelae><chronic complication of COVID-19><chronic effect of COVID-19><chronic novel coronavirus disease 2019><clotting disorder><cognitive defects><cognitive dysfunction><cognitive function><cognitive 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COVID><longterm COVID-19><longterm consequences of COVID-19><longterm consequences of SARS-CoV-2 infection><longterm coronavirus disease><longterm coronavirus disease 2019><longterm effects of COVID-19><longterm health consequences of COVID-19><longterm health consequences of SARS-CoV2 infection><longterm impact of COVID-19><longterm impact of SARS-CoV-2 infection><memory dysfunction><neurocognitive decline><neurocognitive impairment><neurocognitive outcomes of coronavirus disease-19><neurocognitive symptoms and sequelae during COVID-19><novel><pathophysiology><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><persistent COVID-19><physical conditioning><physical health><physical symptom><pilot study><poor sleep><post COVID cognitive impairment><post COVID syndrome><post COVID-19 complications><post COVID-19 related complications><post COVID-19 sequelae><post COVID-19 syndrome><post 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infection><prolonged COVID-19 symptoms><prospective><quality of sleep><rehab therapy><rehabilitative><rehabilitative therapy><research study><respiratory><respiratory symptom><response><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe acute respiratory syndrome coronavirus 2 associated cytokine storm><severe acute respiratory syndrome coronavirus 2 cytokine storm><severe acute respiratory syndrome coronavirus 2 disease severity><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 induced cytokine storm><severe acute respiratory syndrome coronavirus 2 related cytokine storm><severe acute respiratory syndrome coronavirus 2 severity><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><sleep debt><sleep deficiency><sleep deficit><sleep disruption><sleep dysregulation><sleep insufficiency><sleep loss><sleep quality><sleep-related breathing disorder><survive COVID-19><survive SARS-CoV-2><therapeutic target><trait>