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Principal Investigator: Edwin Jose Asturias
Organization: UNIVERSITY OF COLORADO DENVER
Fiscal Year: 2024
Award: $596,565
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
PROJECT SUMMARY
Despite recent progress, accelerated implementation of highly effective and sustainable public health policies
will be required to meet the Sustainable Development Goals’ (SDG) targets for maternal and child health by
2030. The broad goal of this application is to continue to participate in all collaborative activities relevant to the
mission of the Global Network (GN), which aims to develop and test potential sustainable interventions through
collaborative, large-scale, high impact multi-site common research protocols. The primary objective of our
research unit (RU), which represents a partnership between the University of Colorado and Guatemala, is to
develop and test interventions to mitigate the priority threats to maternal-child health posed by malnutrition and
infection in the context of the rapidly changing environment. The specific research expertise of our team is
nutrition, infectious diseases, and biological effects of environmental stressors. This objective will be met
through the following specific aims: 1) continue and enhance a strong research record and productivity as GN
members; 2) continue to develop common GN protocols through high-impact clinical trials and observational
studies that are transformative for maternal-child health; and 3) continue to foster a progressively stronger
research partnership with our colleagues and collaborators in Guatemala and other GN sites. During the past
5-yr cycle, this RU has built a strong research record, evidenced by more than 60 GN publications
(approximately 40% led by our team); by completion of longitudinal growth and neurodevelopment follow-up
through 2 years in the four sites of the preconception maternal nutrition intervention trial; actively consulting on
child neurodevelopmental follow-up for two other major GN trials; strengthened research capacity in
Guatemala; successful implementation of all GN-initiated common protocols, including COVID-19 surveillance,
with contribution of a high percentage of participant numbers and retention to each study; initiation of analyses
to demonstrate adverse effects of maternal exposure to high ambient temperatures on fetal growth and birth
outcomes; and securing external funding to support common protocol implementation. Major contributions to
the GN by this RU include service on 2 subcommittees and co-chairing the oversight committee for the
ongoing Maternal Newborn Health Registry. The positive impact of our continued participation in the GN will be
accomplished by leveraging our combined expertise in nutrition, infectious diseases, and environmental
stressors to design interventions to improve maternal, infant, and child health and resilience within the context
of a changing environment.
Terms: <0-11 years old><0-4 weeks old><Acceleration><Active Follow-up><Address><Adverse effects><Air><Area><Azadose><Azithromycin><Azitrocin><Azythromycin><BMI><BMI percentile><BMI z-score><Biological><Birth><Body mass index><COVID surveillance><COVID-19 surveillance><COVID19 surveillance><Child><Child Health><Child Malnutrition><Child Undernutrition><Child Youth><Childhood Nutritional Deficiency><Children (0-21)><Clinical Trials><Colorado><Communicable Diseases><Competence><Conceptions><Development><Discipline of obstetrics><Dose><Environment><Exposure to><Fe element><Fetal Growth><Fostering><Funding><Generalized Growth><Goals><Growth><Guatemala><Guatemalan><Health><Health Policy><Heat Stress><Human><Inequity><Infant><Infant Health><Infant Mortality><Infant Mortality Total><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Information Dissemination><Institution><International><Intervention><Intervention Strategies><Intervention Trial><Interventional trial><Investigators><Iron><Iron deficiency anemia><Lactation><Link><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malnutrition><Manuscripts><Maternal Exposure><Maternal Health><Maternal Nutrition><Maternal and Child Health><Maternal diet><Mentors><Mentorship><Micronutrients><Mission><Modern Man><Neural Development><Newborn Infant><Newborns><Nutritional Deficiency><Obesity><Observation research><Observation study><Observational Study><Observational research><Obstetrics><Oral><Outcome><Over weight><Overweight><Panama><Participant><Parturition><Perinatal><Peripartum><Pilot Projects><Preparation><Prevention><Productivity><Protocol><Protocols documentation><Public Health><Publications><Quetelet index><Registries><Research><Research Personnel><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><SARS-CoV-2 surveillance><Scientific Publication><Secure><Sepsis><Services><Site><Supplementation with zinc><Sustainable Development><Temperature><Testing><Tissue Growth><Ultreon><Undernutrition><Universities><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Woman><Zinc><Zinc supplementation><Zithromax><Zitromax><Zn element><Zn supplementation><active followup><adiposity><biologic><blood infection><bloodstream infection><career development><children dietary deficiency><climate change><climatic changes><coronavirus disease 2019 surveillance><coronavirus disease surveillance><corpulence><cost effective><death among infants><death in first year of life><death in infancy><death in infants><developmental><dietary deficiency><disease stressor><dissemination of results><early pregnancy><effective intervention><efficacy trial><environmental stresses><environmental stressor><evidence base><field based data><field learning><field study><field test><follow up><follow-up><followed up><followup><food insecurity><global climate change><health care policy><healthcare policy><high risk infant><improved><infant death><infant demise><infant morbidity><infant outcome><infantile death><intervention design><interventional strategy><intra-uterine growth><intrauterine growth><kids><lactating><lactational><malnourished><maternal nutrition during pregnancy><maternal outcome><member><mortality in infants><mother nutrition><mother outcome><multidisciplinary><neonatal health><neonatal morbidity><neonatal sepsis><neurodevelopment><newborn child><newborn children><newborn health><newborn morbidity><nutrition><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><offspring><ontogeny><pandemic><pandemic disease><pilot study><pregnant><preparations><prevent><preventing><prospective><resilience><resilient><severe acute respiratory syndrome coronavirus 2 surveillance><social><syndemic><synergistic epidemic><therapy design><treatment design><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease><vulnerable infant><youngster><zinc supplement>