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Principal Investigator: Annie Lu Nguyen
Organization: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Fiscal Year: 2024
Award: $128,437
Funding agency: National Institute on Aging
PROJECT SUMMARY/ABSTRACT
Advancements in therapy have drastically improved life expectancy for people living with HIV and many
individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years
and older, make up almost half of all individuals living with HIV in the US. Although life expectancy has
increased, older adults living with HIV have greater risk for multiple physical, mental, and psychosocial health
burdens compared to uninfected older adults. It is well documented that people living with HIV are at increased
risk for impaired cognition, including cognitive impairment leading to dementia and Alzheimer’s Disease, and
HIV associated neurocognitive disorders (HAND). The consequences of cognitive impairment among this
population have far reaching implications for population and public health. Impaired individuals may lose the
ability to fully engage in activities involved in HIV care, such as adherence to antiretroviral therapies. Impaired
individuals may also lose the ability to fully engage in other health promoting and beneficial behaviors such as
participate in physical and leisure activities, and activate or utilize positive resources like social support,
purpose in life, and financial resources. Taken within a broader life course context, having multiple life
stressors may also negatively impact the ability to engage in health behaviors and resources and influence
cognitive outcomes. However, research has yet to disentangle the impact of cognition on engagement in
healthy behaviors within the context of positive resource utilization in older adults with HIV. A greater
understanding of this is needed given the aging of the population living with HIV and the corresponding public
health burden. The overall goals of the proposed Career Development Award (K01) goals are to investigate the
relationship between cognitive deficits and health promoting behaviors, clarify the moderating role of positive
resources, and to determine the cumulative impact of these interactions on quality of life for older adults
experiencing stress while living with HIV. This will be achieved through the completion of the proposed training
plan, organized under the four content domains of cognition, HIV and aging, biostatistics and longitudinal
research design, and professional development. This training plan was designed with the goal of launching the
PI’s career as an independent investigator with a research program focused on the interplay of cognition,
psychosocial factors, and life stress on health and successful aging in individuals aging with HIV.
Terms: <21+ years old><AD dementia><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Adult><Adult Human><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Attention><Behavior><Behavioral><Biometrics><Biometry><Biostatistics><Buffers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Characteristics><Chronic><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Community Health><Consequences of HIV><Continuity of Care><Continuity of Patient Care><Continuum of Care><Data Analyses><Data Analysis><Data Collection><Dementia><Development><Dimensions><Disparities><Disparity><Disturbance in cognition><Exposure to><Goals><HIV><HIV 1 associated neurocognitive disorder><HIV Infections><HIV anti-retroviral><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV neurocognitive impairment><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-associated neurocognitive disorder><HTLV-III Infections><HTLV-III-LAV Infections><Health><Health Benefit><Health Promotion><Health Resources><Health behavior><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Impaired cognition><Impairment><Individual><Intervention><Intervention Strategies><Investigators><K-Awards><K-Series Research Career Programs><LAV-HTLV-III><Leisure Activities><Life><Life Cycle><Life Cycle Stages><Life Expectancy><Life Stress><Lymphadenopathy-Associated Virus><Memory><Mental Depression><Mental Health><Mental Hygiene><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurologic><Neurological><Older Population><Outcome><Participant><Perception><Persons><Physical activity><Play><Population><Primary Senile Degenerative Dementia><Psyche structure><Psychological Health><Psychosocial Factor><Public Health><QOL><Quality of life><Research><Research Activity><Research Career Program><Research Design><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Salutogenesis><Social support><Stigmatization><Stress><Study Type><Time><Training><Virus-HIV><Vulnerable Populations><adulthood><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><antiretroviral therapy><antiretroviral treatment><career><co-morbid><co-morbidity><cognitive defects><cognitive dysfunction><cognitive loss><cohort><community-based health><comorbidity><data interpretation><demographics><depression><design><designing><developmental><disability><experience><falls><health related behavior><improved><innovate><innovation><innovative><interventional strategy><life course><life span><lifespan><mental><multiple data sources><neurobehavioral><older adult><older adulthood><older groups><older individuals><older person><population aging><population health><primary degenerative dementia><programs><promoting health><psychosocial><psychosocial resources><psychosocial variables><research study><senile dementia of the Alzheimer type><social role><social stigma><social support network><stigma><stressor><study design><substance use><substance using><therapy adherence><therapy compliance><vulnerable group><vulnerable individual><vulnerable people>