Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
R. Sharon Chinthrajah · STANFORD UNIVERSITY · 2024 · $312,716 — PROJECT SUMMARY The objective of our Cooperative Center for Human Immunology (CCHI) is to use the analysis of vaccine induced immunity and natural infections to Influenza and Sars COV-2 as a model for defining adaptive and innate immune mechanisms and antiviral protection in adults. The Clinical …
RICHARD G WUNDERINK · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $229,472 — PROJECT SUMMARY CORE B Lower respiratory tract infections cause nearly 80% of deaths from infectious diseases in the US, and respiratory viruses, such as influenza and SARS-CoV-2, are increasingly recognized as common causes of severe community-acquired pneumonia (CAP). As mortality from severe CAP …
Raymond Paul Goodrich · COLORADO STATE UNIVERSITY · 2024 · $1,493,669 — Project Summary: The BSL3 suites in the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) have been operational and at capacity since being commissioned. These facilities support research in response to new threats from established pathogens, such as Mycoba…
Colin S. Duckett · DUKE UNIVERSITY · 2024 · $953,343 — ABSTRACT- Facility Management, Maintenance and Operations Core (Core 1) To serve the primary mission of the Duke RBL, it is imperative that the facility itself operates to the highest operational standards. The overall goal of this Aim is to ensure that we can maintain reliable and uninterrupted fac…
Laura F. Gibson · WEST VIRGINIA UNIVERSITY · 2024 · $179,050 — The Technology and Resources for Core Laboratories Core (Technology Core) of the West Virginia Clinical and Translational Science Institute (WVCTSI) supports research infrastructure critical for rapid translation of innovation to positively impact the health of West Virginians. Importantly, the Tech…
JOHN BILLIMEK · UNIVERSITY OF CALIFORNIA-IRVINE · 2023 · $561,185 — Project Abstract Community health workers (CHWs) played an essential role in addressing multi-level, community barriers to accessing COVID-19 information, testing, risk mitigation, and vaccination; however, little is known about how CHWs managed their roles in light of enormous social, community, an…
Jeffrey Andrew Sparks · BRIGHAM AND WOMEN'S HOSPITAL · 2023 · $782,510 — PROJECT SUMMARY The 5 million Americans living with systemic autoimmune rheumatic diseases (SARDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are at increased risk of poor COVID-19 outcomes. SARO treatment with immunomodulators may lead to blunted and dysregulated imm…
Diego G Diel · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2023 · $768,711 — The ongoing pandemic of COVID-19 is designated by World Health Organization (WHO) as a Public Health Emergency of International Concern. Similarities among ACE2 receptors predict that there are several animals could function as reservoirs for the virus. Recent studies by us and others identified fel…
Alexander Viloria Winnett · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2023 · $52,694 — PROJECT SUMMARY Morbidity and mortality in COVID-19 is the result of an exaggerated inflammatory response causing severe tissue and organ damage. However, the biological mechanism for why some individuals progress from initially stable to ultimately critical condition has not been fully elucidated. …
Mariano Juan Kanamori Nishimura · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 · $753,712 — PROJECT SUMMARY/ABSTRACT LatiNET will use a multilevel social network model to examine how SARS-CoV-2 misinformation and Conspiracy Theory (CT) messages are shared across five settings (friends, family, work, health service and influencers), impacting Latinx vaccine hesitancy. Social networks are se…
Jonathan L Zelner · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2023 · $645,067 — Project Summary/Abstract The distribution of disease and death from the COVID-19 pandemic has been grossly unequal in every dimension. The vaccination campaign, throughout Winter and Spring 2021, has seen these inequities repeated. Lower-risk, wealthier, and Whiter individuals have received earlier …
STEVEN A BENNER · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2023 · $313,900 — Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins Foundation for Applied Molecular Evolution Steven Benner ABSTRACT Under PAR-19-253, the NIGMS seeks new technologies that create a positive feedback loop that drives science forward by allowing new questions to be ask…
DEAN R MADDEN · DARTMOUTH COLLEGE · 2023 · $2,460,000 — The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards lo…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $987,497 — ABSTRACT As underscored by pandemic COVID-19, Zika, yellow fever and chikungunya viruses, new and emerging viruses represent increasing threats to human health, yet their mechanisms of emergence remain poorly understood, and effective interventions are not available for most. Research on their patho…
STEVEN A BENNER · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2023 · $671,088 — Basic Research to Diagnostics and Surveillance in Lower Resource Environments Foundation for Applied Molecular Evolution Steven A. Benner ABSTRACT We will deliver to the NIAID and CDC communities, through basic research, a scientific understanding of pairing, mispairing, and enzymology of natural …
Emily Elizabeth Mevers · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2023 · $30,000 — PROJECT SUMMARY/ABSTRACT Natural products have provided the key starting materials to improve human health by providing therapeutic agents and structural templates for medicinal chemists for generations. Thus, the field is certain to remain contemporary if it continues to embrace the current challen…
NELSON B. FREIMER · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $3,072,053 — Abstract Many studies have shown the disproportionately high rates of SARS-CoV-2 infection and its medical complications, including death, experienced by individuals with pre-pandemic severe mental illness (SMI). By contrast, very few studies have thus far attempted to rigorously examine the impact …
Mohamed Abdel Mohsen · RUSH UNIVERSITY MEDICAL CENTER · 2023 · $207,052 — PROJECT SUMMARY Recent data show that 10-30% of coronavirus disease 2019 (COVID-19) patients do not fully recover and suffer from a wide range of symptoms that persist after the SARS-CoV-2 infection has been cleared (so-called post- COVID-19 syndrome or Long Hauler). Severe COVID-19 and associated r…
Sally Lynn Hodder · WEST VIRGINIA UNIVERSITY · 2023 · $4,000,000 — West Virginia (WV), the only state located entirely in Appalachia, has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The WV Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Institutional Devel…
Jin Liu · WASHINGTON STATE UNIVERSITY · 2023 · $278,687 — Virus infections remain major threats to human health worldwide as demonstrated by COVID-19 pandemic caused by SARS-CoV-2 and its variants. All enveloped viruses must fuse with host membranes to initiate the infection process. Membrane fusion is a critical, but poorly understood biological process…