Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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John T Chang · VA SAN DIEGO HEALTHCARE SYSTEM · 2020 — DESCRIPTION (provided by applicant): Mortality from chronic infectious diseases, including Hepatitis C, HIV, and tuberculosis, remains a major problem among Veterans, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal fea…
Rong Xu · PROFECTUS BIOSCIENCES, INC. · 2020 · $69,471 — Abstract Profectus Biosciences leverages its platform technologies of adjuvanted DNA vaccines to stimulate robust Th1- biased immune responses likely necessary for protection against challenging viral diseases such as HIV. We believe that optimized delivery methods are critical for development of ef…
SAUL r TZIPORI · TUFTS UNIVERSITY BOSTON · 2020 · $247,500 — We seek NIH funding to develop a vaccine against cryptosporidiosis for children in LMIC. As no effective therapies exist, there is a critical need for vaccination to reduce morbidity and mortality attributed to cryptosporidiosis, which is estimated to cause diarrhea in >10 million children and kills…
David M Koelle · UNIVERSITY OF WASHINGTON · 2020 · $563,301 — Project Summary: The waning of immunity has a major impact on morbidity and mortality in the aged. Antigen-specific, acquired, and especially T-cellular is important in host defense against chronic intracellular pathogens and cancer. Infections with these microbes and skin cancers with high mutation…
Elias Sayour · UNIVERSITY OF FLORIDA · 2020 · $158,188 — Abstract: I am now in my first faculty position as an Assistant Professor of Neurosurgery and Pediatrics at the University of Florida. I completed a T32 NIH fellowship at Duke University in Cancer Biology and Developmental Therapeutics before accepting a junior faculty position at the University of …
Michael S Diamond · WASHINGTON UNIVERSITY · 2020 · $956,340 — PROJET SUMMARY/ABSTRACT Globally, the four serotypes of DENV cause an estimated 390 million new cases of dengue fever and 500,000 cases of dengue hemorrhagic fever (DHF) per year. Zika virus (ZIKV) is a related emerging virus linked to Guillain-Barre syndrome in adults, and microcephaly, congenital …
Elana Ben-Akiva · JOHNS HOPKINS UNIVERSITY · 2020 · $45,520 — The overall goal of this project is to engineer novel biodegradable cationic polymers for intracellular delivery of nucleic acid materials to antigen presenting cells (APCs) for cancer immunotherapy applications. Immune cells are conventionally very difficult to transfect, and the most successful pl…
JOSEPH M FOX · UNIVERSITY OF DELAWARE · 2020 · $2,349,582 — Project Summary The goal of this Center of Biomedical Research Excellence is to continue our efforts to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approa…
Michael Daniel Keller · CHILDREN'S RESEARCH INSTITUTE · 2020 · $89,250 — Abstract Chronic norovirus infection can cause chronic diarrhea and wasting in immunocompromised patients, including those undergoing hematopoietic stem cell transplantation and with primary immunodeficiency disorders. There are currently no available therapies to treat norovirus. Our preliminary da…
Derek B. Sant'Angelo · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · 2020 · $477,000 — Summary There are at least 49 members of the BTB-ZF gene family, which includes PLZF, BCL6, ThPOK, LRF and others. Only a few have been studied in the context of immune system development or function. Expression of the known BTB-ZF genes correlates with specific functions of the cells – in many ways…
Hui Hu · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $491,617 — Project Summary CD4+ T follicular helper (Tfh) cells are essential for germinal center (GC) responses and long- term humoral immunity. However, the complex regulation that determines the differentiation of Tfh cells, their developmental progression in GC, and their number and function in helping GC…
Natalie Lea Silver · UNIVERSITY OF FLORIDA · 2020 · $155,304 — PROJECT SUMMARY/ABSTRACT Oral cavity squamous cell carcinoma (OCSCC) is a very aggressive and deadly disease with poor survival rates following maximal treatments such as surgery and chemoradiotherapy. The immunosuppressive tumor microenvironment (TME) is a major barrier of response to traditional …
YASUHIRO SUZUKI · UNIVERSITY OF KENTUCKY · 2020 · $459,000 — Chronic infection with Toxoplasma gondii can reactivate and cause life-threatening toxoplasmic encephalitis in AIDS patients and other immunocompromised individuals. The basis of persistence of this chronic infection is the tissue cyst. Thus, eliminating T. gondii cysts from chronically infected ind…
Esteban Daniel Erben · RBHS-NEW JERSEY MEDICAL SCHOOL · 2020 · $185,166 — PROJECT SUMMARY Trypanosoma brucei causes African trypanosomiasis in humans and livestock. In the mammalian infectious Bloodstream-Form (BF) stage, T. brucei expresses a single species of Variant Surface Glycoprotein (VSG) genes from over 2,500 VSG repertoire with a potential of switching to a diffe…
Scheherazade Sadegh-Nasseri · JOHNS HOPKINS UNIVERSITY · 2020 · $543,021 — Unconventional sources of peptides for antigen presentation Project Abstract The long term goals of this project are to understand how the antigen processing pathway generates peptide/MHC class I complexes (pMHC I) by cryptic translation. Numerous studies, from different laboratories, have shown th…
Rachel Riley · UNIVERSITY OF PENNSYLVANIA · 2020 · $9,473 — PROJECT SUMMARY Recent advances in genome sequencing has enabled the detection of random somatic mutations, or neoantigens, in cancer cells from individual patient samples. Thus, neoantigens are ideal targets for cancer vaccination because they avoid harmful toxicities to healthy cells, and they are…
Jae U Jung · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $26,293 — Project Summary/Abstract The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SA…
TORU TAKIMOTO · UNIVERSITY OF ROCHESTER · 2020 · $385,000 — Virus infection induces a wide range of host defense mechanisms, such as the innate immune response and inflammation. Some viruses express accessory proteins to induce general shutoff of host protein synthesis, which is considered to be one of the major viral strategies to counteract host antiviral …
Nan-ping Peter Weng · NATIONAL INSTITUTE ON AGING · 2020 · $275,992 — Maintenance of telomeres is essential for preserving T cell proliferative responses yet the precise role of telomerase in human T cell differentiation, function and aging is not fully understood. Here we analyzed human telomerase reverse transcriptase (hTERT) expression and telomerase activity in si…
Bernard Moss · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $574,999 — Poxviruses encode enzymes and factors needed for transcription and replication of their genomes within the cytoplasm of infected cells. Vaccinia virus, the prototypic member of the poxvirus family, provides a unique system for combining biochemical and genetic approaches for investigating mechanisms…