Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Devanand Sarkar · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $577,461 — Summary Nonalcoholic steatohepatitis (NASH), the most common cause of chronic liver disease in the Western world and a major global health problem, leads to cirrhosis and hepatocellular carcinoma (HCC). The lack of an optimum therapy mandates better understanding of the molecular pathogenesis of NAS…
VINICIO A DE JESUS PEREZ · STANFORD UNIVERSITY · 2024 · $539,264 — Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by abnormally elevated pulmonary pressures and right heart failure resulting in high morbidity and mortality. The pathologic hallmark of PAH is progressive loss and obstructive remodeling of lung microvessels unrespons…
ANDREW K. GODWIN · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $217,550 — ABSTRACT The goals of the Biomedical Engineering (BME) Core within the Kansas Institute of Precision Medicine COBRE is two-fold: (1) Provide pioneering tools for the isolation of Liquid Biopsy Markers (LBMs) and small molecules of biological or clinical importance (Liquid Biopsy Unit); and (2) gener…
Marissa Sobolewski Terry · UNIVERSITY OF ROCHESTER · 2024 · $1,625,947 — A hallmark of Alzheimer’s Disease (AD) is regional brain “iron (Fe) overload”. We hypothesize that life- long exposure to inhaled Fe via air pollution (AP) is a contributor to elevated brain Fe and AD risk. In support of this hypothesis, AP has been linked to increased risk for AD with fine particul…
JAKE JINKUN CHEN · TUFTS UNIVERSITY BOSTON · 2024 · $565,425 — Patients with type 2 diabetes (T2D) have substantially higher incidence of bone disorders, including as much as a 64% greater risk of fracture as compared to those without T2D. High blood glucose levels adversely alter bone cell functions, causing decreased bone formation and delayed wound healing w…
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2024 · $298,524 — The primary function of OMICS Core is to provide members of the University of Louisville Alcohol Research Center (ULARC) with the expertise, resources, and facilities needed for metabolomic, proteomic, and bioinformatic analyses of biological samples collected to study nutrition, gut flora/intestina…
Hanrui Zhang · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $632,206 — Lipid-lowering approaches reduce atherosclerotic cardiovascular disease (ACVD), but significant residual risk remains. Macrophage (Mφ) accumulation and defective phagocytic clearance of apoptotic cells (ACs) by Mφs, i.e., defective efferocytosis, promote atherosclerotic plaque vulnerability and subs…
Alan W. Flake · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $315,720 — PROJECT SUMMARY Many monogenic diseases strike prior to or soon after birth and cause significant morbidity and mortality. In utero genome editing (IUGE) takes advantage of normal fetal properties, including small size, abundant progenitor cells, and immature immune system, to safely and efficiently…
Colby Shad Thaxton · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $275,984 — SUMMARY The overall goal of the Lipid-Based Self-Assembled Materials and Characterization Core (LBSAMCC) is to synthesize, characterize, and deliver highly novel therapeutics for ameliorating the devastating effects of nitrogen and sulfur mustards to the eye (Project 1) and skin (Project 2). High-de…
Xiao Wang · UNIVERSITY OF PENNSYLVANIA · 2024 · $675,157 — PROJECT SUMMARY Phenylketonuria (PKU) is an autosomal recessive disorder caused by mutations in the gene encoding phenylalanine hydroxylase (PAH), resulting in the accumulation of phenylalanine (Phe) to neurotoxic levels. Although there are treatment options, ranging from a strict low-Phe diet to an…
MICHAEL L GROSS · WASHINGTON UNIVERSITY · 2024 · $463,905 — Project Summary Mass spectrometry (MS) based footprinting is emerging as a powerful means to answer biological questions about membrane proteins (MPs), which participate in almost all physiological processes and represent more than 60% of drug targets. This approach affords sufficient structural inf…
William H. Gmeiner · DEEP CREEK PHARMA, LLC · 2024 · $1,018,545 — PROJECT SUMMARY Decades of modulating the anti-cancer activity of fluoropyrimidine drugs (FPs) thru schedule optimization, biochemical modulation, and drug combinations have provided a significant, but limited, survival advantage for treating colorectal cancer (CRC) patients with locally advanced or…
Yanhong Guo · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $748,657 — PROJECT SUMMARY/ABSTRACT Abdominal aortic aneurysm (AAA) is defined as a permanent, localized dilatation of the abdominal aorta with the potentially fatal consequence of aortic rupture. The only effective treatment for AAA is open or endovascular surgical repair when AAA patients with symptomatic or…
Keith Thomas Gagnon · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $180,537 — PROJECT SUMMARY Hepatitis B virus (HBV) infection remains an incurable disease. Despite the availability of vaccines and potent anti-viral drugs, nearly 300 million people worldwide are infected with HBV. The challenge with curing HBV is the persistence of the virus’ genome in the form of a double-…
ROBERT G BENNETT · OMAHA VA MEDICAL CENTER · 2024 — Metabolic disorders, such as obesity, are associated with adipose tissue hypoxia, inflammation and fibrosis, and impaired lipid uptake, causing ectopic lipid uptake other organs, such as the liver. Furthermore, the secreted adipokine profile changes dramatically, with impaired secretion of antifibro…
Vladimir R Muzykantov · UNIVERSITY OF PENNSYLVANIA · 2024 · $767,434 — Clinical approval of Lipid Nano Particles (LNP) for RNA heralded the advent of nanotechnology- based pharmacotherapy. Yet, RNA delivery to extra-hepatic sites remains a major unmet challenge. Weissman pioneered modifications of mRNA providing effective translation in diverse cell types, while Muzyka…
PHILIPPE ANDRE GALLAY · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $775,538 — While the development of effective vaccines against CoV-2 is cause for optimism, vaccine hesitancy in developed countries and shortages in low-income countries are jeopardizing efforts to curb the pandemic. Out of the 6.4 billion people living in low-income countries, only 2% have access to vaccines…
Carol H Miao · SEATTLE CHILDREN'S HOSPITAL · 2024 · $758,254 — PROJECT SUMMARY The goal of this project is to combine the technology of lipid nanoparticles (LNPs) and CRISPR/Cas9 gene editing tools to correct the mutant factor VIII (FVIII) genes and rescue hemophilia A (HemA) phenotype. HemA is a bleeding disorder resulting from a deficiency of the X-linked FVI…
Irina V Balyasnikova · UNIVERSITY OF COLORADO DENVER · 2024 · $533,757 — Project Abstract Glioblastoma (GBM) is the most devastating and aggressive brain tumor in adults, with patients surviving a median of only 14.6 months. Hidden behind the blood-brain and blood tumor-barrier (BBTB), the glioma cells migrating away from the tumor and invading surrounding brain tissue, …
Irene Ann Chen · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $384,106 — Project Summary Phages are viruses that infect bacteria, and are the most abundant type of organism on earth. In addition, phages are a potential antibacterial therapy. The overall focus of the project is phage- inspired engineering for antibacterial applications and fundamental evolutionary studies…