Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Julie E. Ledgerwood · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $485,881 — The evaluation of a vaccine candidate targeting COVID-19 and collection of samples to support translational immunology research support the broader VRC mission. For this project, sample collection was conducted under the VRC 200 protocol while the evaluation of an investigational vaccine candidate …
DEBORAH M HINTON · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2021 · $290,679 — Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgAP), and virulence activated genes are expressed (the Bvg(+) mode). When B…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2021 · $1,300,391 — Our recognition of the fundamental mechanisms of mRNA expression, exemplified by the regulated expression of HIV, provided the basics for our interest in developing preventive HIV DNA based vaccine strategies. Attractive features of the DNA platform lie in its simplicity, versatility, stability, wit…
ALAN REIN · DIVISION OF BASIC SCIENCES - NCI · 2021 · $610,882 — There appear to be several different modes of interaction between retroviral proteins and nucleic acids, each with important functional consequences for viral replication. First, an exquisitely specific recognition by the Gag polyprotein (the structural protein of the virus particle) selects the vir…
George N. Pavlakis · DIVISION OF BASIC SCIENCES - NCI · 2021 · $1,489,039 — We explored the biology of IL-15 and showed that efficient production of IL-15 is possible only by co-expression in the same cell with the so-called IL-15 Receptor-alpha. We also showed that a second form of IL-15 (SSP IL-15) previously identified in humans and rodents as intracellular or nuclear IL…
Christopher Parks · INTERNATIONAL AIDS VACCINE INITIATIVE · 2019 · $2,353,868 — DESCRIPTION (provided by applicant): The overall goal of this HIVRAD consortium is to develop and compare four novel vaccine candidates designed to deliver HIV envelope (Env) trimers mimicking the presentation of Env by HIV infection and ultimately generating broadly neutralizing antibodies (b…
Thomas R Hawn · UNIVERSITY OF WASHINGTON · 2019 · $179,469 — Despite the discovery of Mycobacterium tuberculosis (Mtb) over 100 years ago and the availability of effective drugs for over 60 years, there remain formidable hurdles for controlling tuberculosis (TB) disease including the lack of a highly efficacious vaccine, long drug treatment regimens, preventi…
Derek Walsh · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $470,119 — PROJECT SUMMARY Humans have a profound, double-edged relationship with poxviruses. On one hand, the devastating effects of smallpox are unparalleled by any other pathogen in recorded history, and its eradication is a milestone in modern medicine. On the other, poxviruses are now used as highly effec…
John T Chang · VA SAN DIEGO HEALTHCARE SYSTEM · 2019 — DESCRIPTION (provided by applicant): Mortality from chronic infectious diseases, including Hepatitis C, HIV, and tuberculosis, remains a major problem among Veterans, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal fea…
Sean PJ Whelan · HARVARD MEDICAL SCHOOL · 2019 · $503,415 — DESCRIPTION (provided by applicant): This application is to renew a grant to study RNA synthesis in minus-strand RNA viruses. Nonsegmented negative-sense (NNS) RNA viruses include some of the most significant human pathogens that are an ongoing threat to US public health. For measles, mumps and…
Hulin Wu · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2019 · $346,500 — DESCRIPTION (provided by applicant): Owing to the significant cost reduction of high-throughput technologies, frequent time course genome-wide gene expression data, in addition to time course cellular level and longitudinal phenotype response data, are often collected in recent HIV/AIDS studies…
Joshua Woodward · UNIVERSITY OF WASHINGTON · 2019 · $389,875 — DESCRIPTION (provided by applicant): Listeria monocytogenes is a gram-positive, opportunistic, intracellular bacterial pathogen that causes food borne illness. Given its well-characterized infection cycle and genetic amenability, L. monocytogenes provides a powerful tool to interrogate the fund…
CHRISTIAN TSCHUDI · YALE UNIVERSITY · 2019 · $760,910 — DESCRIPTION (provided by applicant): This application focuses on the protozoan parasite Trypanosoma brucei, which causes devastating diseases in humans and animals in sub-Saharan Africa. There are no vaccines, and therapeutic drugs have serious side effects and decreasing efficacy. Thus, there …
GEORGE M SHAW · UNIVERSITY OF PENNSYLVANIA · 2019 · $706,916 — DESCRIPTION (provided by applicant): Recent vaccine studies in nonhuman primates have demonstrated the potential for virus-specific CD8 T cell responses to constrain or eradicate SIV infection. Rhesus CMV (RhCMV) and other persistently and non- persistently replicating vectors have contributed …
RICHARD J. HODES · DIVISION OF BASIC SCIENCES - NCI · 2019 · $296,536 — The src family kinase lck plays a critical role in T lymphocyte development and activation. Expression of lck is regulated by two promoters, termed distal and proximal promoters, in both mice and humans. Although the existence of these promoters was described 20 years ago, their function in developi…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2019 · $2,251,746 — Our recognition of the fundamental mechanisms mRNA expression, exemplified by the regulated expression of HIV, provided the basics for our interest in developing preventive HIV DNA based vaccine strategies. Attractive features of the DNA platform lie in its simplicity, versatility, stability, with r…
ALAN REIN · DIVISION OF BASIC SCIENCES - NCI · 2019 · $471,212 — There appear to be several different modes of interaction between retroviral proteins and nucleic acids, each with important functional consequences for viral replication. First, an exquisitely specific recognition by the Gag polyprotein (the structural protein of the virus particle) selects the vir…
DEBORAH M HINTON · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2019 · $410,289 — Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgAP), and virulence activated genes are expressed (the Bvg(+) mode). When B…
Carole Long · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $1,131,973 — Dry Season Ecology of Malaria Vectors Our work continues to focus on: (1) Windborne long-range migration of mosquitoes as strategies of vector and malaria persistence in the Sahel, and (2) Mosquito dormancy (aestivation) through the dry season to account for the persistence of A. coluzzii . Building…
Barney Graham · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $3,806,087 — Improvements in vaccines against influenza that increase potency, breadth and duration of protection would improve worldwide ability to combat seasonal changes in influenza viruses (drift) and emergence of new pandemic strains (shift). This study aims to develop new platforms and vaccination strateg…