NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
WEI WENG · INGENIOUS TARGETING LABORATORY, INC. · 2022 · $292,710 — With the initial wave of zoonotic transmission firmly established in the human population worldwide, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) poses an eminent threat to individuals, health care systems and societies. Various degrees of disease severity (from asymptomatic …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Kari C. Nadeau · STANFORD UNIVERSITY · 2022 · $175,246 — SUMMARY The 2019 coronavirus disease (COVID-19) caused by the novel coronavirus 2 (SARS-CoV-2) has infected more than 16 million people worldwide and claimed the life of more than 650,000 persons worldwide within the past seven months. Several patient subgroups are at greater risk of more severe COV…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Rihe Liu · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $194,375 — Abstract The Covid-19 pandemic caused by SARS-Cov-2 has resulted in 38.3 million infection cases across 188 countries and territories with more than 1.08 million deaths by October 14 2020. While various vaccines are under expedite development, there is a serious concern that future variants of SARS…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Kyeong-Ok Chang · KANSAS STATE UNIVERSITY · 2022 · $735,037 — PROJECT SUMMARY Human coronaviruses generally cause the common cold, a mild upper respiratory illness, however, global outbreaks of new human coronavirus infections with severe respiratory disease have periodically emerged from animals. These include Severe Acute Respiratory coronavirus (SARS-CoV), …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Qizhi Gong · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $586,386 — RESEARCH SUMMARY Sudden-onset of olfactory loss has been recognized as a common COVID-19 symptom. The mechanism of COVID-19 related olfactory dysfunction is unknown. Whether the degree of olfactory deficit is indicative of any long-term neurological diseases in COVID-19 has not been evaluated. Recen…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Mingtao Zhao · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2022 · $234,000 — Down syndrome (DS) is the most common genetic disorder occurring in about 1 in 800 live births, and is characterized by a distinctive facial appearance, intellectual disability, and developmental delays. Gene dosage imbalance in DS patients, primarily caused by an extra copy of chromosome 21 (trisom…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Lawrence James Purpura · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $192,102 — PROJECT SUMMARY/ABSTRACT: Rationale: The COVID-19 pandemic has affected over 42 million individuals in the United States and long-term complications are frequently reported, referred to as post-acute sequelae of SARS-CoV-2 (PASC). Even among survivors with mild acute illness, neurologic symptoms suc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Sixto Manuel Leal · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $668,250 — Project summary Unlike most invasive mold infections, COVID Associated Pulmonary Aspergillosis (CAPA) occurs in individuals with otherwise intact immune systems suggesting novel biological mechanisms mediating susceptibility to fungal infection. This proposal seeks to evaluate the novel conceptual a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Stijn Piet Johan De Langhe · MAYO CLINIC ROCHESTER · 2022 · $954,000 — Idiopathic pulmonary fibrosis (IPF) is a common form of interstitial lung disease (ILD), resulting in alveolar remodeling and progressive loss of pulmonary function, respiratory failure, and death often within 5 years of diagnosis. Genetic and experimental evidence support the concept that chronic a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
ELLIOTT D CROUSER · OHIO STATE UNIVERSITY · 2022 · $576,575 — The SARS CoV-2 pandemic has resulted in >550,000 deaths in the USA alone. Therapeutic options for critically ill patients with COVID-19 are limited. Prior studies showed that development of severe hypoxemia and lung inflammation in influenza A virus-infected mice is associated with inhibition of de …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Laurent Olivier Mosnier · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $443,750 — Project Summary This application seeks to improve basic understanding of the molecular mechanisms that mediate cytoprotective actions of coagulation proteases on cells and will test novel approaches for the potential treatment of thrombo- inflammatory disease. Despite recent advances, major gaps in …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Sanjana Dayal · UNIVERSITY OF IOWA · 2022 · $673,720 — Project Summary Infection with severe acute respiratory syndrome novel corona virus (SARS-CoV-2) causes COVID-19. In severe cases, COVID-19 leads to profound inflammation (“cytokine storm”) followed by coagulopathy and a prothrombotic-state with progression to multiple organ failure. Several cytokin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Tejal A. Desai · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $809,270 — PROJECT SUMMARY: The COVID-19 pandemic, caused by the new coronavirus SARS-CoV-2, has had a remarkable impact on public health worldwide with the largest number of cases and deaths reported in the United States. Improved understanding of COVID-19 will accelerate the development of effective therapeu…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Susan Bailey Gurley · OREGON HEALTH & SCIENCE UNIVERSITY · 2022 · $456,192 — Project Summary Hypertension affects more than 60 million people in the US and despite its diverse causes, blockade of the renin-angiotensin system (RAS) lowers blood pressure in the majority of hypertensive patients. ACE2 is the newest member of the RAS, and our previous work has established that A…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Tian Jin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $16,675 — We have started the project Identification of co-receptor and components involved in the entry of SARS-CoV-2 using a quantitative phosphoproteomic approach. We developed a mass-spectrometry method to detect changes of protein phosphorylation in live cells upon stimulations. This method combines ta…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Nash Rochman · NATIONAL LIBRARY OF MEDICINE · 2022 · $648,935 — Our work over the past year may be divided into two aims: understand the extent of the mutational repertoire accessible to Severe acute respiratory syndrome coronavirus 2 in an effort to forecast epidemiological outcomes at a molecular level, and to more broadly understand how changing social and en…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Philippe Youkharibache · DIVISION OF BASIC SCIENCES - NCI · 2022 · $37,847 — A significant part of my recent research efforts is focused on studying self-association determinants of molecular systems as revealed by their structural symmetries at several levels: from proteins assemblies to their protein supersecondary structures constituents (protodomains) [You…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Jesse D Bloom · UNIVERSITY OF WASHINGTON · 2022 · $1,225,278 — PROJECT SUMMARY – CORE C: VIRAL EVOLUTION The Viral Evolution Core will develop tools to inform the engineering of vaccines that broadly target coronaviruses that pose a pandemic risk. To do this, the core will use deep mutational scanning to define the biochemical and functional properties of RBDs …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Matthew Bryan Frieman · WASHINGTON UNIVERSITY · 2022 · $1,441,507 — Project Summary – Animal Challenge Core B The Animal Challenge Core B will develop and provide key virus stocks for four different human and animal coronaviruses (CoVs) that have pandemic potential. These viruses belong to the subgenera of Sarbecovirus and Merbecovirus and will be used by the Core f…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
BINA JOE · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · 2022 · $193,125 — 7. Project Summary/Abstract Animal models fare indispensable for understanding the pathology of COVID-19 as well as for developing vaccines. They are also important to discern the etiology of COVID-19 in specific groups at risk, such as individuals with pre-existing hypertension. While there are ham…