Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
YOSHIHIRO KAWAOKA · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $194,375 — PROJECT SUMMARY The pandemic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus can cause severe and even fatal infections in some patients, primarily those with comorbidities such as hypertension, diabetes mellitus, obesity, and cardiovascular disease. In addition, immunocompromise…
Rihe Liu · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $224,925 — Abstract The Covid-19 pandemic caused by SARS-Cov-2 has resulted in 38.3 million infection cases across 188 countries and territories with more than 1.08 million deaths by October 14 2020. While various vaccines are under expedite development, there is a serious concern that future variants of SARS…
CALVIN J KUO · STANFORD UNIVERSITY · 2021 · $393,625 — ABSTRACT The COVID-19 pandemic, engendered by the novel coronavirus SARS-CoV-2, is a grave threat to public health, with lung infection and respiratory failure. However, the intestine is also targeted by SARS-CoV-2, as many patients present with GI symptoms and the SARS-CoV-2 receptor angiotensin-co…
George Ueda · UNIVERSITY OF WASHINGTON · 2021 · $308,875 — Broader Impacts: The current COVID-19 outbreak is a global pandemic with over 45 million cases and 1,200,000 deaths officially reported. Epidemiological data emerging from Italy indicate that 40-96% of COVID- 19 patients admitted into the hospital develop ARDS and sepsis. Developing a functional tre…
Tian Jin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $64,404 — We have started the project Identification of co-receptor and components involved in the entry of SARS-CoV-2 using a quantitative phosphoproteomic approach. We developed a mass-spectrometry method to detect changes of protein phosphorylation in live cells upon stimulations. This method combines ta…
Marshall Elliott Bloom · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $8,717 — Since early 2020, the COVID-19 pandemic, caused the novel -coronavirus SARS-CoV-2, has ravaged the world and has disrupted much biomedical research. Consequently, we decided to focus a portion of our efforts on human coronaviruses, like SARS-CoV-2 and the Middle East Respiratory Syndrome coronavirus…
John Schneekloth · DIVISION OF BASIC SCIENCES - NCI · 2021 · $148,693 — Traditional drug screening strategies are based on targeting coronavirus-related proteins (e.g., RdRp, Mpro, and 3CLpro) and receptors (e.g. ACE2). In addition to virus-coded proteins, RNA structures within the SARS-CoV-2 genome also regulate essential functions and are potentially attractive and co…
Tongqing Zhou · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $606,667 — The SARS-CoV-2 pandemic has caused more than 220 million confirmed infections and almost 4.5 million deaths globally. Great efforts have been made for the development of vaccines and therapeutics. Isolation of virus-neutralizing monoclonal antibodies could be one approach to treat or prevent infecti…
leping li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $1,040,862 — Project 1: Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines Studies that characterize human cancer cell lines and evaluate their sensitivity to drugs provide valuable information about the therapeutic potential and the possible mech…
Monica Kraft · UNIVERSITY OF ARIZONA · 2021 · $371,166 — During the first cycle of our AADCRC program, our project focused primarily on Surfactant Protein A (SP-A), a known innate immune modulator that exhibits important anti-inflammatory effects in asthma. In this renewal, we show preliminary data that SP-A binds the interleukin (IL)-6 receptor and disru…
Megan Sykes · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $283,116 — Project Summary: There is growing evidence that an overexuberant innate and adaptive immune response may contribute to life-threatening pulmonary pathology in COVID-19 disease. On the other hand, inadequate viral control may allow severe disease to develop. Human immune system (HIS) mouse models hav…
Helene D Benveniste · STATE UNIVERSITY NEW YORK STONY BROOK · 2020 · $463,521 — ABSTRACT SARS-CoV-2 contact with the organism starts with binding to its key receptor ACE2 which is highly expressed in the ciliated cells of the tracheal, bronchial, and nasal mucociliary epithelium. After binding, the virus inhibits the cilia beating in the airways and suppresses mucociliary trans…
Jochen Reiser · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $459,623 — ABSTRACT From early studies and published reports indicate kidney injury is one of the manifestations of COVID-19. The human kidney is a direct target of the virus, as the angiotensin-converting enzyme 2 (ACE2), a putative receptor for SARS-CoV-2, is highly expressed in the kidney tubules. As direct…
RICHARD A GIBBS · BAYLOR COLLEGE OF MEDICINE · 2020 · $100,000 — OVERALL PROJECT SUMMARY The novel coronavirus, SARS-CoV-2, that was first detected in China in December 2019 has now spread globally. The Texas Medical Center in Houston, TX, the fourth largest city in the US, and among the top 10 in racial diversity, mounted an aggressive early response to the pand…
KATHLEEN E. RODGERS · UNIVERSITY OF ARIZONA · 2020 · $1,533,089 — PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is a progressive multifactorial disease affecting more than 50 million people worldwide, and is the most common dementia of late-life. To date, no interventions have demonstrated substantial therapeutic efficacy to prevent, delay or treat AD. In rece…
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2020 — With prevalence higher than 33% in United States, hypertension is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. According to the Veterans’ Affairs (VA) Office of Research & Developmen…
Ian Myles · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $12,447 — Alterations in ACE2 caused by the SARSCoV2 infection are preventing proper functioning of TACE leading to an increase in membrane bound TNF and/or TNFR2 retention subsequently local hyperproliferation and ECM deposition or alterations in the nicotinic acetylcholine receptor. Perhaps a treatment tar…
Tongqing Zhou · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $339,649 — The SARS-CoV-2 pandemic has caused more than 29 million confirmed infections and almost 1 million deaths globally. Great efforts have been made for the development of vaccines and therapeutics. Isolation of virus-neutralizing monoclonal antibodies could be one approach to treat or prevent infection …
Michael Edwin Boulton · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $403,279 — This proposal examines the hypothesis that diabetes results in a pathological change in the communication between the bone marrow (BM) and gut leading to dysfunction in both compartments. Angiotensin converting enzyme 2 (ACE2) converts angiotensin II (ANG II) to angiotensin 1-7(Ang 1-7) which, by vi…
Catalin Filipeanu · LSU HEALTH SCIENCES CENTER · 2020 · $633,177 — With prevalence as high as 55% for individuals aged 55 and older in United States, hypertension is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. The role of the renin-angiotensin syst…