Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
HENRY DANIELL · UNIVERSITY OF PENNSYLVANIA · 2020 · $795,892 — PROJECT SUMMARY/ABSTRACT Current Protein Drugs (PD) are prohibitively expensive ($140 billion in top ten PDs, >75% of global GDP). One third of global population earning <$2 per day can’t afford any PD. Insulin, a five-decade old drug, is still unaffordable, even in developed countries, as illustra…
Jason Knight · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $390,000 — ABSTRACT This Coronavirus Disease 2019 (COVID-19) supplement will study the role of neutrophil extracellular traps (NETs) as biomarkers and therapeutic targets in COVID-19. The supplement will preserve the parent project’s focus on ectoenzymes and purinergic signaling as amplifiable counterpoints to…
Suzanne Devkota · CEDARS-SINAI MEDICAL CENTER · 2020 · $371,859 — Project Summary The COVID-19 pandemic currently has infected over 4 million people worldwide and led to over 300,000 deaths. These numbers continue to grow and with an anticipated resurgence in the fall and winter months. It is now clear that SARS-CoV-2 can enter the gastrointestinal (GI) tract, tha…
Kenan Christopher GARCIA · STANFORD UNIVERSITY · 2020 · $553,964 — ABSTRACT The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened global health. The severity of disease and rising number of deaths from SARS-CoV-2 have raised an urgent need for effective therapies. Besides respiratory symptoms, 20-50% of patients…
JOHN M. LITTLETON · NAPROGENIX, INC · 2020 · $140,059 — Abstract The parent award is to develop novel medications for alcohol and nicotine use disorders. These disorders have increased during COVID19 [e.g. Clay and Parker 2020] and are associated with increased susceptibility to, and severity of, infection. This supplemental proposal is focused on how me…
Abraam M. Yakoub · UNIVERSITY OF NORTH DAKOTA · 2020 · $226,172 — Project Summary Coronavirus Disease of 2019 (COVID-19) is a US and global public health crisis. It has led to the deaths of, at the point of writing this application, over 476,000 patients and 10 million infected individuals worldwide. The US was the most affected country, with over 123,000 deaths …
Erin R Hascup · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · 2020 · $368,750 — Project Summary/Abstract The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created a healthcare crisis that was previously reserved for the accelerating Alzheimer’s disease (AD) diagnoses. Geriatric individuals are a high risk group prone to severe infection and d…
Amal O Amer · OHIO STATE UNIVERSITY · 2020 · $460,500 — Summary This administrative supplement (under NIH PA-18-591 Administrative Supplements to Existing NIH Grants and Cooperative Agreements) seeks funding for research responsive to the SARS-CoV-2/COVID-19 outbreak that falls within the scope of the ongoing grant 5R01AI124121-05. The original grant (5R…
Murugappan Ramanathan · JOHNS HOPKINS UNIVERSITY · 2020 · $196,500 — Program Director/Principal Investigator (Last, First, Middle): Ramanathan, Murugappan Jr It is estimated that while the majority of SARS-CoV-2 infections in the ongoing coronavirus disease-2019 (COVID-19) pandemic are asymptomatic or have mild symptoms, hospitalizations and mortality largely occurs …
Elizabeth Gray · UNIVERSITY OF HOUSTON · 2020 · $34,690 — Abstract The increasing world-wide prevalence of obesity is a worrying public health problem and crisis. Coexistence of obesity, hypertension and diabetes significantly increases the risk of kidney dysfunction. In obesity, concentrations of angiotensin II (Ang II) increase, while those of Ang-(1-7) …
Jyoti K Jaiswal · CHILDREN'S RESEARCH INSTITUTE · 2020 · $489,740 — ABSTRACT Down syndrome (DS), also known as trisomy 21, is the most common chromosomal abnormality among live- born infants. DS is associated with a disproportionate high risk for severe viral respiratory infections, a top cause of mortality in this vulnerable population. Nonetheless, the risk of DS …
PAUL T WINGFIELD · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2020 · $1,592,641 — In uninfected cells, RNA is transcribed from DNA, processed, and then transported out of the nucleus and translated into protein. In cells infected with HIV-1, the viral RNA genomes must be exported out of the nucleus without being processed so they can be packaged into new viral particles. To do th…
BRIAN KELSALL · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $10,000 — Demonstrating that SARS-CoV-2 infects and replicates in intestinal epithelium in vivo has been inconclusive. Therefore we have begun to stain intestinal tissues from infected macaques for viral antigen and cell markers to determine if infection occurs and what cells are infected. Furthermore, It ha…
Lothar Hennighausen · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2020 · $1,379,483 — Objective 1 Angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV and SARS-CoV-2, has been detected in a range of target cells, including lung epithelium, kidney and other epithelial cells. While SARS-CoV-2 infection of lung epithelium is a critical driver of disease, extrapulmonary mani…
Philippe Youkharibache · DIVISION OF BASIC SCIENCES - NCI · 2020 · $28,601 — A significant part of my recent research efforts is focused on studying self-association determinants of molecular systems as revealed by their structural symmetries at several levels: from proteins assemblies to their protein supersecondary structures constituents (protodomains) [Youkharibache 2019…
Adolfo Garcia-Sastre · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $878,495 — PROJECT 2: ABSTRACT Project 2 is based on evidence that lung cancer patients have higher susceptibility to SARS-CoV-2 infection and increased risk of severe disease and mortality. This increased vulnerability is likely due to a combination of factors, including immune-suppressing effects of the canc…
Jason Davin Gardner · LSU HEALTH SCIENCES CENTER · 2020 · $404,754 — Project Summary Nicotine is the addictive component of tobacco-derived products. Through binding to a family of nicotinic acetylcholine receptors (nAChRs), nicotine influences a diverse range of cellular mechanisms involved in homeostasis and disease. Although cigarette smoking is a major risk fact…
ROBERT M LAVKER · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $410,000 — PROJECT SUMMARY/ABSTRACT The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying structures from injury, in part, through the elaboration of the limbal and corneal epithelia. It is well- accepted that the limbal epithelium is the site o…
Jamie M Verheyden · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $434,000 — PROJECT SUMMARY The COVID19 pandemic has spread across the globe with unprecedented speed and devastation. With infected individuals rising past 1.4 million in the US, there is a dizzying amount of information causing confusion around which tissues SARS-CoV-2 infects and how it triggers catastrophi…
Jason Davin Gardner · LSU HEALTH SCIENCES CENTER · 2020 · $312,700 — Project Summary Nicotine is the addictive component of tobacco-derived products. Through binding to a family of nicotinic acetylcholine receptors (nAChRs), nicotine influences a diverse range of cellular mechanisms involved in homeostasis and disease. Although cigarette smoking is a major risk fact…