Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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Jack H Freed · CORNELL UNIVERSITY · 2020 · $494,198 — Abstract: This project is aimed at the study of properties of membrane proteins that underlie important biomedical processes and are implicated in health disorders and how they interact with their membrane environments. By means of the latest one and two dimensional electron-spin resonance (ESR) met…
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2020 · $531,000 — Project Summary Membrane fusion, mediated by HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], is the first critical step for the virus to enter host cells and establish infection. A mature Env spike contains three copies each of noncovalently-associated receptor-binding…
COSIMO COMMISSO · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2020 · $195,000 — PROJECT SUMMARY The world has been shocked by the recent COVID-19 pandemic. Macropinocytosis is a form of endocytosis that viruses use to gain entry into cells or to facilitate infection. Our laboratory has the most extensive experience in investigating macropinocytosis in the context of cancer, whe…
JASON S DEBLEY · SEATTLE CHILDREN'S HOSPITAL · 2020 · $193,352 — Project Summary This application is an Emergency Competitive Revision (PA-20-135) to existing NIH award K24AI150991 proposing immediate work to help address the urgent need for research on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19). While the…
Leonardo Trasande · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $339,000 — PROJECT SUMMARY The novel coronavirus pandemic (COVID-19) has largely spared children, with relatively few requiring medical care. A small case series failed to reveal effects on birth outcomes in mothers with COVID-19 pneumonia, yet the absence of effects may in part relate to these mothers having …
Michael R. Farzan · SCRIPPS FLORIDA · 2020 · $331,181 — SAR-CoV-2 (2019-nCoV) is a human pathogenic coronavirus that is very similar to the SARS coronavirus (SARS-CoV or SARS-CoV-1). As of this writing, more than 40,000 people are reported to be infected with this virus, causing more than 1,000 deaths. It is hoped that the number of new cases will declin…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2020 · $137,715 — Parent Grant Abstract/Summary Cells migrating in tissues use filopodia to interact with and move through their 3D environment. Filopodia are slender actin-filled projections composed of a core of cross-linked, parallel actin bundles. They are highly dynamic, vary in length and are found in a wide v…
Michael G Agadjanyan · INSTITUTE FOR MOLECULAR MEDICINE · 2020 · $389,064 — Project Summary Two months after the first report of a U.S. death from COVID-19, the death rate is 228 per million people, the tenth highest rate globally. The mortality rate from COVID-19 in those aged 45-54 years is ~5%, and it increased to 13% in people of 50-60 years old, and sadly 80% of all U.…
Shao-Cong Sun · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $162,946 — PROJECT SUMMARY/ABSTRACT Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) causes coronavirus disease 2019 (COVID-19), which is characterized by acute inflammation in the lung and other organs, such as the heart and intestine. It is increasingly clear that the pathogenesis o…
George A Truskey · DUKE UNIVERSITY · 2020 · $280,600 — Abstract The appearance of SARS-CoV-2 in early 2020 has spurred efforts to limit the disease spread and develop effective treatments. The most promising long-term approach is a vaccine. While some vaccines are entering accelerated clinical trials, it may take 12 or more months before an effective va…
Rama Rao Amara · EMORY UNIVERSITY · 2020 · $292,855 — The overall goal of this proposal is to develop effective prophylactic vaccines against the novel SARS Coronavirus-2 (SARS-CoV-2) infection that has recently emerged as a pandemic across the world. The SARS-CoV-2 has already infected more than 120,000 people and over 4000 people died due to COVID-19…
Mark Joseph Mulligan · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $9,214,781 — PROJECT ABSTRACT This supplement proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) research to be carried out at the NYU VTEU. We will participate in the implementation of a COVID-19 vaccine efficacy trial “A Phase III Randomized, Double-blind, Placebo-controlled Mu…
Lanying Du · NEW YORK BLOOD CENTER · 2020 · $832,650 — Summary A novel coronavirus (CoV), SARS-CoV-2, is causing global pandemics with growing numbers of daily cases and deaths. SARS-CoV-2 is closely related to SARS-CoV, which caused the 2002-2003 SARS epidemic, and less closely related to MERS-CoV, which causes a high mortality rate in infected patient…
Kimberly Frances Raab-Graham · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $88,123 — PROJECT SUMMARY Overview: The project focuses on understanding the molecular basis of how disrupted calcium homeostasis leads to disrupted hippocampal network activity that results in maladaptive responses in neurons with TSC deficient signaling. Approximately 33% of children who have autism spectru…
Rama Rao Amara · EMORY UNIVERSITY · 2020 · $102,106 — The overall goal of this proposal is to develop effective prophylactic vaccines against the novel SARS Coronavirus-2 (SARS-CoV-2) infection that has recently emerged as a pandemic across the world. The SARS-CoV-2 has already infected more than 120,000 people and over 4000 people died due to COVID-19…
Moshe Arditi · CEDARS-SINAI MEDICAL CENTER · 2020 · $184,894 — PROJECT ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic has been associated with the emergence of a new febrile pediatric entity called multisystem inflammatory syndrome in children (MIS-C), that involved systemic hyperinflammation, multiorgan involvement and gastrointestinal symptoms. In …
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2020 · $293,054 — Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and invasiveness of cancer cells. Filopodia are slender actin-filled projections composed of a core of cro…
Lynda Coughlan · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $4,732 — SUMMARY: The emergence of the SARS-CoV-2 coronavirus (CoV) highlighted our lack of preparedness, and has emphasized the importance of rapidly building capacity in the development of reagents, tools, diagnostics and therapeutics for SARS-CoV-2 and related CoVs with pandemic potential. An immediate go…
URSZULA T IWANIEC · OREGON STATE UNIVERSITY · 2020 · $73,720 — PROJECT SUMMARY SARS-CoV-2, the viral cause of Coronavirus Disease 2019 (COVID-19), is a highly contagious coronavirus, which upon infection results in a non-uniform distribution of clinical response. SARS-CoV-2 infects the lung and other organs, including liver and immune system, with non-lung infe…
Richard J. Kuhn · PURDUE UNIVERSITY · 2020 · $381,463 — PROJECT SUMMARY This proposal aims to rapidly generate vaccine candidates against the 2019 novel coronavirus SARS-CoV- 2. Since its emergence about three months ago, this virus has caused more than 120,000 infections and 4,300 deaths worldwide and is rapidly spreading to virtually every country inc…