Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Peter Gordon Barr-Gillespie · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $499,631 — PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) is one of seven National Primate Research Centers (NPRCs) established by Congress in the 1960s. The NPRCs are sponsored by the NIH Office of the Director, and serve the nation's biomedical research needs in a unique and essential fa…
AMIN S GHABRIAL · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $335,807 — Ghabrial – Project Summary To build a functional vascular system, a network of endothelial tubes must be generated through a combination of vasculogenesis and angiogenesis. During sprouting angiogenesis, endothelial tip cells lead the outgrowth of new branches. Tip cells anastomose with other tip ce…
VAHRAM HAROUTUNIAN · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $1,268,438 — PROJECT SUMMARY Alzheimer’s disease (AD) stands out as notable in two respects––in not having a cure and in affecting women more than men. While declining estrogen has been thought to underpin post–menopausal AD, there is a clear clinical correlation of AD with rising levels of follicle–stimulating…
TRACEY MCLAUGHLIN · STANFORD UNIVERSITY · 2021 · $236,175 — PROJECT SUMMARY/ABSTRACT Obesity is a major risk factor for severe outcomes in Covid-19, exceeding the risk associated with type 2 diabetes and hypertension by 3-fold. The underlying reason is unknown. While obese individuals may have an impaired immune response or a predilection towards inflammatio…
Yehia Mechref · TEXAS TECH UNIVERSITY · 2021 · $316,105 — Glycosylation is one of the most complex protein modifications; more than 50% of mammalian proteins are glycosylated. The fact that there are 100,000 proteoforms coded by only ~20,300 genes identified in the human genome emphasizes the importance of posttranslational modifications (PTMs) like glycos…
Niraj Tolia · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $289,320 — SARS-CoV-2 is a serious global threat that has been met with an unparalleled research response. Scientific understanding of SARS-CoV-2 is already deeper than most pathogens and it is growing rapidly. This knowledge provides an opportunity to design a vaccine that goes beyond traditional methods. …
Aleksandra Nita-Lazar · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $2,762 — The focus of the proteomic approach is to identify and quantify viral structural proteins, specifically spike (S) glycoprotein as well as envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein in patient samples. The S protein mediates attachment of the virus to the host cell surfa…
JOHN H KEHRL · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $51,546 — Beta-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is known regarding their cellular entry and replication pathways, but their mode of egress remains uncertain. Using imaging methodologies and …
paolo lusso · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $121,121 — The project has yielded the following results: 1. Synthesis of tail-modified SARS-CoV2 envelope spike (S) mRNAs to facilitate VLP formation with lentivirus core proteins. In order to facilitate the assembly of VLPs containing lentivirus (HIV-1 or SIV) core proteins, we have designed S proteins modif…
William Copeland · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $453,829 — During this fiscal year we continued to devote major effort to work aimed at applications of molecular dynamics and quantum mechanics/molecular mechanics simulations required to help support the computational chemistry and molecular modeling needs of NIEHS scientists. Some projects involved creatio…
Robert Petrovich · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $1,629,843 — The protein expression facility (PEF) functions as a support group for the principal investigators at the NIEHS. Our focus is to provide the research groups with a means to generate the proteins they require so that they can perform their experiments. These projects range from generating enough o…
Jason Matthew Elinoff · CLINICAL CENTER · 2021 — In FY21, we determined the expression levels of known and putative host viral entry molecules including angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), neuropilin 1 (NRP1), and DC-SIGNR (CD209L/CLEC4M) in primary human lung endothelial cells (ECs). Results were com…
Thomas Nutman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $163,096 — In response to the SARS-CoV-2 pandemic, we leveraged our expertise in human T cell cloning to generate SARS-CoV2-specificT cell lines from nave CD4+ and CD8+ T cells of uninfected (SARS Cov2-nave) individuals. To this end, we generated S-specific, M-specific, CMV-specific (controls) human TCLs (a to…
Audray Harris · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $249,426 — Coronaviruses remain both a seasonal health burden and pandemic threat due to the antigenic variation of viral glycoproteins and the ability of animal coronaviruses to cause zoonotic infections in humans. Although conserved epitopes have been identified, there is a fundamental gap in understanding a…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $203,488 — (1) Animal model development: We have established the Syrian hamster model for pathogenesis studies and countermeasure development. Following intranasal inoculation of SARS-CoV-2, hamsters consistently developed moderate broncho-interstitial pneumonia, with high viral lung loads and extensive virus …
vineet n kewalramani · DIVISION OF BASIC SCIENCES - NCI · 2021 · $356,986 — Using lentiviral vectors pseudotyped with SARS-CoV-2 Spike protein, we are examining different SARS-CoV-2 variants for their ability to interact with CLEC4M, and whether this interaction facilitates direct infection of cells or efficient transfer and infection of cells expressing canonical SARS-CoV-…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2021 · $650,195 — To characterize immune responses in SARS-CoV2 infected persons we examined a cohort of infected persons over 10 months post symptoms onset. Elucidating the characteristics of human immune response against SARS-CoV-2 is of high priority and relevant for determining vaccine strategies. We reported the…
alexander wlodawer · DIVISION OF BASIC SCIENCES - NCI · 2021 · $208,788 — Recently, angiotensin-converting enzyme 2 (ACE2) was shown to be a functional receptor for SARS-CoV-2, enabling the virus to enter host target cells. Using structure-based rational design, a chimeric ACE2 peptide was designed by us for use as a ligand for analytical quantitation of SARS-CoV-2. We ai…
di s xia · DIVISION OF BASIC SCIENCES - NCI · 2021 · $23,607 — Lead identification. Based on the well-established principle that the S proteins carry out all the cell entry functions of CoVs, the CoV S spike were incorporated onto a replication defective HIV core, resulting pseudovirions with SARS-CoV-2 S protein expressed on the surface of viral envelop. Trans…
Christian Mayer · DIVISION OF BASIC SCIENCES - NCI · 2021 · $7,906 — This research was primarily carried out by the cooperating laboratories. Through the use of single-cell BCR cloning and other techniques, antibody responses were characterized in patients with a history of SARS-CoV2 infection, Hepatitis B virus (HBV) infection / vaccination, as well as in animals in…