Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Lawrence A. Tabak · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2021 · $957,584 — Our lab studies the structure and function of GalNAc-Ts. We published a methods paper in Glycoconjugate J. on mapping O-glycans using solid phase extraction (SPE) enrichment, protease digestion, and Electron-transfer/Higher Energy Collision Dissociation (EThcD) fragmentation. This work utilized O- p…
KOEN K VAN ROMPAY · WEILL MEDICAL COLL OF CORNELL UNIV · 2021 · $217,604 — ABSTRACT – Overall Nearly 600,000 new HIV infections occur yearly in adolescents/young adults (ages 15-24 years), the only population in which HIV infections continue to rise. The end of the HIV/AIDS epidemic will be achievable only when an effective vaccine regimen can elicit long-term protective i…
Alexey Zakharov · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $184,902 — Phage display is one of most effective molecular diversity techniques, it has been used for the selection of antibodies from diverse libraries. Several facilities (Uchicago, Utoronto, UCSF) in the world have built automated phage display robot for generation of conventional antibodies to the proteom…
PAUL T WINGFIELD · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2021 · $1,638,558 — In uninfected cells, RNA is transcribed from DNA, processed, and then transported out of the nucleus and translated into protein. In cells infected with HIV-1, the viral RNA genomes must be exported out of the nucleus without being processed so they can be packaged into new viral particles. To do th…
Bernard R Brooks · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $1,048,765 — Migration of CHARMM to GPUs Graphical Processing Units (GPUs) are modern processors with the ability to support the concurrent execution of thousands of threads at the same time. In this work we have redesigned the CHARMM codebase from a heterogeneous CPU-GPU architecture to a GPU-only architecture…
GREG WITHAM · ANP TECHNOLOGIES, INC. · 2021 · $19,727,817 — The extreme severity of the current COVID-19 outbreak represents the single worst outbreak in recent years. Exacerbated by the fast moving, highly contagious, asymptomatic disease progression and high mortality in vulnerable populations, particularly those in low resource areas, the need for a rapid…
Cynthia Ann Derdeyn · EMORY UNIVERSITY · 2021 · $223,125 — Project Summary/Abstract HIV research efforts are strongly focused on developing vaccines that can elicit highly protective antibody responses. There is evidence from human and nonhuman vaccine studies that both neutralizing and non- neutralizing antibody activities contribute to protection against …
Lanying Du · NEW YORK BLOOD CENTER · 2021 · $102,509 — Project Summary Viral subunit vaccines are safe and convenient, but generally suffer low efficacy. Our overall hypothesis is that an intrinsic limitation is associated with subunit vaccine designs in which artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine eff…
Jian Xu · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $441,479 — PROJECT SUMMARY There is a pressing urgency to understand the regulatory mechanisms that control the expression of ACE2, the cellular receptor for the new coronavirus SARS-CoV-2, in human cells under physiological and pathological conditions. The binding between ACE2 and the SARS-CoV-2 spike protein…
YUICHIRO Justin SUZUKI · GEORGETOWN UNIVERSITY · 2021 · $80,496 — Summary/Abstract Currently the world is suffering from the pandemics of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter host cells. So far, over five million people ha…
Shana O Kelley · UNIVERSITY OF TORONTO · 2021 · $295,888 — Project Summary: The COVID-19 pandemic has highlighted the shortcomings of existing testing approaches for viral infection. Diagnosing active infections using PCR or other amplification strategies is constrained to centralized testing facilities that have limited capacity. New point-of-care molecula…
Nour Al-muhtasib · YALE UNIVERSITY · 2021 · $39,995 — The overall goal of this proposal is to investigate the role of endocannabinoid (ECB) signaling in regulating distinct cortical inhibitory synapses. Physiological brain development and function are dependent on a fine-tuned balance of synaptic excitation and inhibition. As such, dysregulation of inh…
RICK B MEEKER · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $388,750 — HIV infection of the nervous system results in chronic infection, inflammation and cognitive decline in many patients with no effective treatments. Inflammation appears early in the disease process and causes progressive neural damage due, in part, to factors released by activated microglia and macr…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2021 · $2,619,302 — UNAIDS has documented millions of new HIV-1 infections every year, thus a vaccine for HIV-1 is highly desirable. To date, despite numerous efforts, no immunization regimen reproducibly elicits broadly neutralizing antibodies (bNAbs) against HIV-1. Recently available native-like HIV-1 envelope spike …
Kui Kiu Chan · ORTHOGONAL BIOLOGICS, INC. · 2021 · $95,981 — ABSTRACT The spike protein (S) of SARS coronavirus 2, the pathogen responsible for COVID-19, binds angiotensin- converting enzyme 2 (ACE2) as an entry receptor, triggering conformational changes in S that drive fusion of the viral envelope and host cell membrane. Infection is inhibited by neutraliz…
Yicheng Tu · UNIVERSITY OF SOUTH FLORIDA · 2021 · $287,698 — Project Summary We will design and develop a molecular simulation data management system, we call P2DMS, to analyze large dis- tributed molecular dynamics (MD) simulation data. The salient features of the system include: (1) a push-based local query engine design that handles data in a batch process…
Rachael Ann Clark · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $443,750 — SUMMARY COVID 19, the lower respiratory disease caused by the 2019 nCov virus, is the latest betacoronavirus to cause epidemic disease in humans. Previously, SARS and MERS, both cause by related viruses, emerged and fell dormant as epidemics. Betacoronaviruses use homologous “Spike” proteins to bind…
HUAFENG WEI · UNIVERSITY OF PENNSYLVANIA · 2021 · $332,767 — Abstract Coronavirus disease 2019 (COVID-19), a pandemic affecting millions of patients around the world, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with no effective drug treatments. Both infection and transfection of virus in host cells require abnormally elevated C…
Amit Praful Khandhar · HDT BIO CORPORATION · 2021 · $927,069 — Project Summary/Abstract A key requirement for HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope (Env) spike. The BG505 SOSIP.664 gp140 soluble timer is engineered to display conformational epitopes recognized by several bNAbs but not …
STEVEN A BENNER · FIREBIRD BIOMOLECULAR SCIENCES, LLC · 2021 · $258,854 — Reagents to Chemically Tag Specific Coronavirus Spike Proteins Firebird Biomolecular Sciences, LLC. Steven A. Benner Bharat Gawande Abstract While vaccines and antivirals may be long term solutions to the current coronavirus pandemic, it is now widely appreciated that the pandemic can be managed …