Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Prajwal Gurung · UNIVERSITY OF IOWA · 2024 · $504,819 — PROJECT SUMMARY Pathogen recognition receptors and their associated adaptors are essential for the prompt detection of pathogens and the subsequent initiation of effective host responses and restoration of homeostasis. Over the last decade, Nod-like receptors (NLRs) have been on the forefront of inn…
Mariana Angoa-Perez · JOHN D DINGELL VA MEDICAL CENTER · 2024 — Project Summary/Abstract Gulf War Veterans’ Illnesses (GWVI) presents as a complex constellation of diverse symptoms that have persisted in Gulf War Veterans more than 25 years after their deployment to the Gulf region. This set of symptoms is so broad, it baffles diagnostic criteria and as a result…
Niketa A. Patel · JAMES A. HALEY VA MEDICAL CENTER · 2024 — This application is for Research Career Scientist award for Niketa A. Patel, Ph.D., 8/8th VA, PI of active VAMR award, national peer-reviewed research support since 2005, office (Room 303-4) and laboratory (Suites 300 and 303) in James A. Haley Veterans’ Hospital Research Service space. I have devel…
David E Kang · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2024 — Accumulation of toxic proteins (i.e. Aβ42 & tau) and dysfunctional mitochondria are associated with synaptic and neuronal loss in multiple neurodegenerative disorders, including Alzheimer’s disease (AD). Such clearance defects are thought to arise in large part from deficits in the autophagy-lysosom…
SNIGDHA BANERJEE · KANSAS CITY VA MEDICAL CENTER · 2024 — Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide, including US Veterans. An initial response to chemotherapy, such as Gemcitabine (GEM) is often followed by emergent resistance reflecting an urgent need for targeted therapies. Our studies have …
Gary A Jarvis · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — The overall research program of the applicant has focused on the role of LOS and the innate immune system and has shown that the degree of phosphorylation of the lipid A component is correlated with the potential of the LOS to induce innate immune cytokine-mediated inflammation and, in general, with…
Thomas L Clemens · BALTIMORE VA MEDICAL CENTER · 2024 — The prevalence of osteoporosis among men is still under-recognized. The patient population of the Veterans Health Administration (VHA) is predominantly male and many Veterans may be at risk of osteoporosis. Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. Large-sc…
Robert Nissenson · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — The maintenance of healthy bones in adults requires coordinated bone turnover where bone formation is closely coupled to bone resorption, allowing bone renewal with the maintenance of bone mass. Uncoupling of bone formation and bone resorption underlies the loss of bone mass seen in a variety of con…
HEATHER E VOLK · JOHNS HOPKINS UNIVERSITY · 2024 · $371,244 — Neurodevelopmental disorders (NDDs), including ASD, affect over 15 percent of US children – Autism Spectrum Disorder (ASD) alone affects approximately 1.5% of US children. Identification of underlying causes can lead to primary and secondary prevention efforts. Substantial evidence supports contribu…
Clayton Swanson · VETERANS HEALTH ADMINISTRATION · 2024 — The objective of this CDA-1 proposal is to launch my independent research career in the area of mobility function and rehabilitation in Veterans with neurological impairments. Specifically, I am interested in the neural control of turning while walking, which is often impaired for older adults and p…
Joonsoo Kang · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $707,833 — Summary Immunological control of mucosal barrier development and maintenance is a critical process, as imbalances in immune sentinel activity can lead to skin, lung and gut inflammatory diseases. Central in the mucosal tissue homeostasis are type 3 cytokine producing lymphocytes. Cytokines, cytokine…
Linda Jones Herbert · CHILDREN'S RESEARCH INSTITUTE · 2024 · $507,451 — PROJECT SUMMARY / ABSTRACT Food allergy is highly prevalent, burdensome, and stressful. Food allergy affects up to 7% of adolescents in the United States, or two adolescents in every classroom. Anaphylaxis, a multi-systemic allergic reaction, can be fatal if not treated with epinephrine quickly, and…
John Joseph Mekalanos · HARVARD MEDICAL SCHOOL · 2024 · $999,436 — Modified Project Summary/Abstract Section Vibrio cholerae remains a major threat to world health in that cholera epidemics have ravaged Yemin, Africa, South Asia, and Haiti in only the last decade. This bacterial organism is also a powerful model system for understanding microbial pathogenesis and …
JULIE ZIKHERMAN · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $403,750 — CD28 is a T cell surface molecule that can provide a second signal, when combined with immobilized TCR ligands, to induce naïve T activation. Costimulation results from the interaction of CD28 with its ligands CD80 (B7.1) and CD86 (B7.2) induced on activated antigen-presenting cells by activation of…
RACHEL GOLD · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $575,889 — PROJECT SUMMARY/ABSTRACT: Factors such as food, transportation, and housing instability, social isolation, and neighborhood conditions profoundly impact health outcomes. Shaped by a long history of racial, social, and economic inequity in the US, such factors also underlie health inequities. Many he…
BRIAN L WEISS · YALE UNIVERSITY · 2024 · $190,604 — The midgut of most arthropods is lined by a peritrophic matrix (PM) that is composed of a chitin backbone upon which assemble a variety of glycosaminoglycans and proteins. The PM serves a defensive role within arthropods by protecting their midgut epithelia from abrasive food particles, regulating t…
Jianzhao Bi · UNIVERSITY OF WASHINGTON · 2024 · $6,822 — PROJECT SUMMARY/ABSTRACT This application proposes improved exposure estimation approaches to wildfire smoke impacts to conduct better epidemiologic assessment of kidney health risks, in the setting of a career development proposal. Dr. Jianzhao Bi will create novel wildfire-derived PM2.5 (particula…
Cande V. Ananth · GEORGE WASHINGTON UNIVERSITY · 2024 · $2,555,013 — PROJECT SUMMARY/ABSTRACT Preterm birth is well established as the leading cause of perinatal mortality and a significant contributor to both chronic medical conditions and learning/societal challenges amongst those born too soon. Though complex in its origins, preterm birth is predominantly the resu…
MATTHEW N RASBAND · BAYLOR COLLEGE OF MEDICINE · 2024 · $400,000 — New Abstract: The causes of complex neuropsychiatric disorders including schizophrenia, bipolar disorder, and autism remain poorly understood. Importantly, many neuropsychiatric disorders are highly heritable, indicating the underlying cause is genetic rather than environmental. Large genome-wide…
Sophie Helaine · HARVARD MEDICAL SCHOOL · 2024 · $211,875 — PROJECT SUMMARY Beside the well‐researched antibiotic resistance, bacterial pathogens can survive antibiotic exposure through drug persistence. Persistence has been more difficult to study because of the transiency of the phenomenon, where some bacteria arrest growth, thus surviving several antibiot…