Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Chen Lin · BIRMINGHAM VA MEDICAL CENTER · 2024 — Veterans with post-traumatic stress disorder (PTSD) have an increased risk of developing ischemic stroke. Veterans enduring PTSD face difficulties in managing their PTSD severity after suffering from a stroke. Currently, clinical trials in PTSD exclude patients with stroke and patients with signific…
Daniel Poston · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $35,815 — PROJECT SUMMARY The zoonotic transmission of viral pathogens from animals to humans contributes to the majority of emerging infectious diseases, which pose a substantial and increasing threat to human health. While host innate immunity—namely the production of Type I Interferon (IFN) and the subsequ…
Sebastian E Winter · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $430,673 — PROJECT SUMMARY Infection with the bacterial pathogen Salmonella enterica serovar Typhimurium (S. Tm) is a common cause of inflammatory diarrhea. Intriguingly, intestinal inflammation drives an expansion of the S. Tm population in the gut lumen. The molecular mechanisms that support S. Tm colonizati…
David W Gludish · CORNELL UNIVERSITY · 2024 · $153,630 — This application seeks support for a research-emphasis veterinarian embarking on an independent career as a translational veterinarian-scientist. The applicant proposes to study macrophages as drivers of SARS-CoV2- induced lung damage in humans and mouse models, and will develop novel indicator mice…
Gregory L Brown · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $34,585 — Due to an aging population and increased lifespan, dementia is an increasing clinical and public health issue. The most common and well-known cause is Alzheimer’s disease (AD), but other important disorders are involved in the development of AD-related dementias (ADRD). What is less appreciated is t…
Juan M Melero-Martin · BOSTON CHILDREN'S HOSPITAL · 2024 · $563,978 — PROJECT SUMMARY/ABSTRACT Ischemic diseases, including critical limb ischemia and myocardial infarction, afflict millions of people in the United States. Currently, these diseases are predominately treated by surgical interventions. However, the inability to regenerate microvascular beds in ischemic…
JANINE R MATHEE-SCOTT · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $41,290 — ABSTRACT Current estimates suggest that autism spectrum disorder (ASD) impacts 1 in 44 children in the United States. Many young children with ASD demonstrate language delays, which are often the first area of concern noted by their parents. Young children with ASD show markedly different word learn…
STAVROULA KOUSTENI · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $324,966 — ABSTRACT Osteoblasts are critical components of the hematopoietic stem cell (HSC) niche that regulate hematopoiesis. More recently, they have emerged as critical regulators of the development of hematological myeloid malignancies. We showed that a single activating mutation in -catenin signaling in…
Jill E Johnston · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $824,976 — OVERALL: PROJECT SUMMARY/ABSTRACT Near-roadway and regional air pollution, industrial releases, goods movement and growing oil and gas production in urban areas vulnerable to wildfires all threaten to increase the burden of environmental disease. In California and worldwide, these threats disproport…
Ekaterina Koroleva · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $220,625 — Accumulating evidence suggest that SARS-CoV-2 infection induces tissue pathology in multiple organs in addition to the lung, including, among others, intestine, heart, liver, kidney, and brain. Furthermore, SARS- CoV-2 infection can exacerbate many chronic inflammatory diseases. However, mouse model…
MAGDALENA JANECKA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $1 — Autism spectrum disorder (ASD) affects 1 in 59 children1, and is caused by both genetic and environmental factors. Nevertheless, the modifiable risk factors for this disorder remain unknown, creating a pressing public health need. As ASD likely arises early in prenatal development considerable effor…
MICHAEL L GROSS · WASHINGTON UNIVERSITY · 2024 · $748,641 — The “amyloid hypothesis” posits that Amyloid β (Aβ) misfolds, oligomerizes to soluble species, and thereby contributes to neurodegenerative Alzheimer’s disease (AD). Recent support for the hypothesis comes from a new antibody, Lecanemab, that targets Aβ and its aggregation and significantly reduces …
Pedro Brugarolas · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $351,929 — Project Summary Demyelination represents the hallmark of multiple sclerosis (MS) and is also present in other diseases including brain ischemia, traumatic brain injury and even Alzheimer’s disease. Currently, demyelinating diseases are primarily imaged using MRI. Even though MRI is highly sensitive…
Dileep Varma · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $336,000 — Project Summary: Mitotic cells assemble two key cellular structures to segregate the chromosomes equally between the two daughter cells - the mitotic spindle and the kinetochores. Kinetochores are multi-protein complexes that form at the centromeres of the chromosomes during mitosis and serve as att…
Richard D Mooney · DUKE UNIVERSITY · 2024 · $416,779 — Project Summary Vocal communication depends on distinguishing our own vocal sounds (vocal feedback) from other sounds. Vocal motor-related corollary discharge (vocal CD) signals that suppress auditory responses to predictable vocal feedback help make this distinction. Notably, vocal CD signals in th…
YUH-HWA WANG · UNIVERSITY OF VIRGINIA · 2024 · $329,762 — Project Summary/Abstract: Both physiological DNA breaks occurring during DNA metabolic processes and pathological DNA breaks responding to a wide range of stresses, contribute to the outcome of human genome instability. DNA fragility generated by alternative DNA secondary structures is a known caus…
Judy Lieberman · BOSTON CHILDREN'S HOSPITAL · 2024 · $196,525 — Colorectal cancer (CRC) is the third most diagnosed cancer in the US with the second highest mortality rate. Locally advanced and metastatic disease have a poor prognosis. A small subset (5-15%) of metastatic CRC patients, who bear tumors deficient in DNA mismatch repair (MMR) that have high microsa…
Yang Hu · STANFORD UNIVERSITY · 2024 · $545,696 — PROJECT SUMMARY Normal tension glaucoma (NTG) is characterized by optic neuropathy with progressive retinal ganglion cell (RGC) death and optic nerve (ON) degeneration but in the absence of intraocular pressure (IOP) elevation. All current glaucoma treatments are to lower IOP and are less effective …
Nora Amanda Barrett · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $760,583 — PROJECT SUMMARY Tuft cells are a specialized epithelial cells (EpCs) that initiate airway type 2 inflammation (T2I) through their generation of IL-25 and pro-inflammatory lipid mediators, cysteinyl leukotrienes (CysLTs). We previously reported that airway tuft cells are indirectly activated by commo…
Hossein Ardehali · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $566,077 — Heart failure (HF) is a major health epidemic in developed countries, however, its underlying pathology is not well characterized. Tristetraprolin (TTP) is a tandem zinc finger protein that binds to AU-rich elements (ARE) in the 3’-untranslated region (UTR) of target mRNA molecules, and induces thei…