Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Pallavi P Balte · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2023 · $205,625 — Summary/Abstract Tobacco product use has been well established as a major cause of death and disease, yet the public health burden of tobacco in the context of the COVID-19 pandemic – which has already killed more than 700,000 Americans and radically altered behaviors and health in populations acro…
Peter Daszak · ECOHEALTH ALLIANCE, INC. · 2023 · $577,202 — 1 Two major coronaviral diseases of wildlife origin have emerged in Asia in the last two decades. Both likely 2 began as zoonotic spillover events, leading to small case clusters, but were not identified until significant 3 community spread made control difficult, and in the case of COVID-19, led …
Cynthia Y Tang · UNIVERSITY OF MISSOURI-COLUMBIA · 2023 · $26,418 — Project Summary The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has resulted in over 5 million deaths worldwide. As the burdens of the pandemic in the United States (US) shift from urban to rural communities, preliminary …
Nicholas J. Mantis · WADSWORTH CENTER · 2023 · $824,595 — Project Summary As the COVID-19 pandemic continues to spread across the United States it is imperative that we implement technologies to screen large swaths of the population for the presence of antibodies to SARS-CoV-2. Serological surveillance not only affords a measure of virus exposure within a …
L Lee HAMM · TULANE UNIVERSITY OF LOUISIANA · 2023 · $499,990 — Project Summary – Overall The Tulane National Primate Research Center (TNPRC) is affiliated with Tulane University of Louisiana and was dedicated in 1964. The Center is part of Tulane University Health Sciences along with the School of Medicine, the School of Public Health and Tropical Medicine, and…
Grace C. John-Stewart · UNIVERSITY OF WASHINGTON · 2023 · $298,428 — Abstract Globally, the number of HIV-exposed uninfected (HEU) children/adolescents is growing, with 1.2 million HEU infants born annually1. There is evidence that HEU children have increased morbidity and mortality, and lower neurocognitive scores than their HIV-unexposed (HUU) counterparts. The par…
Anna Karolina Palucka · JACKSON LABORATORY · 2023 · $291,555 — PROJECT SUMMARY Although humanized mice have been successfully used for in vivo studies of HIV infection, cancer and immunotherapies, human naïve and adaptive immune responses remain suboptimal, with limited cross-reactivity between murine and human cytokines considered as a key contributing factor.…
MICHAEL F HAGAN · GORDON RESEARCH CONFERENCES · 2023 · $6,500 — Project Summary Viral infections involve processes from atomic-scale regulation of ionic transport, to macromolecular self- assembly and membrane budding, to global epidemiology. Physical Virology studies these processes as a paradigm for the intersection of fundamental physical laws and emergent b…
Carolyn Y. Fang · TEMPLE UNIV OF THE COMMONWEALTH · 2023 · $1,140,263 — Project Summary Low-Income Asian Americans (AA) with limited English proficiency (LEP) represent a meaningful proportion of low-wage frontline workers in essential service industries. Many also live in multigenerational households with crowded conditions and with their elderly relatives in ethnic ne…
Sally Lynn Hodder · WEST VIRGINIA UNIVERSITY · 2023 · $71,599 — West Virginia (WV), the only state located entirely in Appalachia, has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The WV Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Institutional Devel…
Leah Katzelnick · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $71,625 — Effect of sequential exposure on breadth of immunity to SARS-CoV-2 variants. The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. We collected 201 serum samples from persons with a single infection or multiple vaccine exposures, or both. We measured their neutralization tit…
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $3,718,933 — Novel means first to better characterize and then to treat infection with major respiratory pathogens using existing or newly developed strategies are a primary focus of this important project within the Clinical Research Section. In this regard, our Section has undertaken clinical research efforts …
Andrea Lisco · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $9,869 — The extraordinarily wide spectrum of clinical manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, ranging from completely asymptomatic to fatal disease, represents an unexpected and unexplained clinical feature for an emerging highly contagious nove…
John O'Shea · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2023 · $268,550 — Cytokines comprise a large family of secreted proteins that regulate cell growth and differentiation of many types of cells. These factors are especially important in regulating immune and inflammatory responses, and regulating lymphoid development and differentiation. Not surprisingly, cytokines ar…
Reed Johnson · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,658,179 — Viruses of the Coronaviridae family are enveloped viruses that possess a large (30kb), single-stranded, positive sense, RNA genome that infect a large number of mammals (alpha and beta coronaviruses) and birds (gamma coronaviruses). Four different seasonal coronaviruses (two alpha coronaviruses, 229…
Joseph Frank · CLINICAL CENTER · 2023 — The availability of non-human (NHP) CT data from SARS-CoV-2 animal imaging studies at the Integrated Research Facility (IRF) and human CT data from the COVID-19 pandemic has presented an opportunity to explore the interaction of combining NHP and human CT lung lesion data to enhance deep learning (D…
PAUL A WADE · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $1,998,360 — The Epigenomics and DNA Sequencing Core Lab provides a variety of services to the NIEHS scientific community. For next-generation sequencing, the core produces hundreds of millions of short sequence reads of individual DNA molecules using the Illumina NovaSeq 6000, NextSeq 500 or Illumina's MiSeq pl…
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $3,302,902 — The Environmental Polymorphisms Registry (EPR), now called Personalized Environment and Genes Study (PEGS) of over 17,000 participants provides a unique resource for a variety of studies dedicated to clarifying the interaction of genetic and environmental determinants of human health. The PEGS's sub…
Michael Huerta · NATIONAL LIBRARY OF MEDICINE · 2023 · $358,847,685 — In FY 2023, NLM's national biomedical information services expanded and enhanced access to data and information to accelerate biomedical research and public health. Provided access to biomedical literature Indexed 1+ million MEDLINE citations with medical subject headings (MeSH). Added 1.6 millio…
NICO TJANDRA · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2023 · $1,495,094 — As a progression in developing new technology to characterize dynamic molecular events which regulate important biological function, we chose to look at retroviral capsid assembly. This protein is a part of the Gag-poly protein which is processed as part of the maturation of the virus. The assembly …