Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Hongli Wu · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · 2024 · $180,348 — Summary The most common cause of vision loss among the elderly is cataract. Oxidative stress is well known to cause cellular and tissue damage, resulting in age-associated ocular diseases, including cataract. Protein glutathionylation, the reversible formation of a mixed-disulfide between glutathion…
Anita Singh · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $347,348 — Neonatal Brachial Plexus Palsy (NBPP) is a complication of childbirth that can result in significant long-term sequelae. NBPP associated injuries often include cases of spinal cord injury (SCI) and are very poorly understood. Our long-term research goals are to develop both prevention and treatment …
ERIC HERMES · VA CONNECTICUT HEALTHCARE SYSTEM · 2024 — Background. Medication treatment of Opioid Use Disorder (MOUD) saves lives and is increasingly delivered virtually. Currently, 60% of VA outpatient addiction treatment occurs over video. The pandemic accelerated this trend, but it will be sustained through multiple VA policies. However, toxicology t…
Lauren M Denneson · PORTLAND VA MEDICAL CENTER · 2024 — Background: The suicide rate among female Veterans increased 63% between 2000 and 2014 – significantly higher than the 30% increase observed among male Veterans during this period. Despite a large volume of work examining risk factors, barriers to care, and care utilization among Veterans, little re…
Rebecca Kaufman Sripada · VETERANS HEALTH ADMINISTRATION · 2024 — Background: One third of post-9/11 Veterans in VHA suffer from posttraumatic stress disorder (PTSD), and among those who initiate Cognitive Processing Therapy (CPT), up to 70% drop out before receiving an adequate dose of treatment. Unfortunately, Veterans who drop out prematurely may never receive …
Ulas Sunar · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $1 — PROJECT SUMMARY/ABSTRACT A major challenge in the management of advanced ovarian cancer is the presence of disseminated microscopic tumor nodules within the intraperitoneal cavity. Despite surgery and adjuvant chemotherapy, as many as 50% of patients can show occult disseminated disease, with only …
Robert Edward Kearney · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $509,907 — Neonatal hypoxic-ischemic encephalopathy (HIE) is a neurologic syndrome that results from reduced flow of oxygenated blood to the fetal or newborn brain. HIE occurs in 1-3 per 1,000 term births and may cause death or neurologic disabilities such as cerebral palsy. Electronic fetal monitoring (EFM) w…
Francesco Versace · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $359,579 — PROJECT SUMMARY Progress in basic neuroscience has improved our understanding of addiction neurobiology, but what has proven difficult is translating this knowledge into effective relapse prevention treatments. Identifying the neurobiological mechanisms underlying relapse will likely promote the dev…
Julie R Palmer · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $754,900 — National initiatives in precision medicine, such as the All of Us Research Program, have set ambitious plans to establish a research cohort of one million or more participants and enable a new era of medicine that empowers patients, researchers, and providers to work together toward development of …
Eunsook Yu Lee · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · 2024 · $440,960 — Project Summary Chronic exposure to high levels of manganese (Mn) causes manganism, a neurological disorder which shares multiple pathological features with Parkinson's disease (PD). Mn-induced neurotoxicity includes decreased expression of tyrosine hydroxylase (TH), a rate-limiting enzyme in dopami…
Tobias E Kaeser · VETERINARMEDIZINISCHE UNIVERSITAT WIEN · 2024 · $475,812 — Chlamydia trachomatis (Ct) is the most frequent bacterial sexually transmitted pathogen, and can lead to ectopic pregnancy and infertility. Antibiotics cure infection but may not ameliorate disease and a vaccine is urgently needed. Success in preclinical animal studies is essential for vaccines to m…
Armando Gil Burgos-Rodriguez · UNIVERSITY OF PUERTO RICO MED SCIENCES · 2024 · $2,434,892 — PROJECT SUMMARY/ABSTRACT: The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Sant…
CARRIE BETH OSER · UNIVERSITY OF KENTUCKY · 2024 · $562,683 — ABSTRACT: As outlined in DAT18-08, NIDA has a strong interest in understanding treatment utilization among persons with opioid use disorders (POUDs) as they transition from prison to the community, because treating individuals with opioid use disorder (OUD) simultaneously improves public health and …
Felix Yi-Chung Feng · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $618,546 — Project Abstract Castrate resistant prostate cancer is a uniformly lethal disease and, although there have been a number of new therapeutic agents approved, there is still a large need for more effective treatments in this patient population. In this proposal, we will study a radioligand therapy (RL…
Becky D Clarkson · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $599,799 — PROJECT SUMMARY Prevalent, morbid, and costly (>$20 billion/year in 2000), incontinence is a major problem, especially for older adults, in whom the most common type is urgency urinary incontinence (UUI). Ascribed to bladder spasms, UUI's actual causes are unknown, and therapy remains inadequate. Re…
Erin Faye Gillespie · UNIVERSITY OF WASHINGTON · 2024 · $263,033 — PROJECT SUMMARY/ABSTRACT The overall goal of this NCI K08 career development proposal is to facilitate Dr. Erin Gillespie’s development into an independent investigator in cancer health services research focusing on strategies to enhance quality and evidence-based care in radiation oncology. This p…
Louis J. Dell'Italia · BIRMINGHAM VA MEDICAL CENTER · 2024 — Project Summary There is a gap in the knowledge for staging in patients with primary mitral regurgitation (PMR) because there is a 20% chance of having an LV ejection fraction (EF) < 50% after mitral valve repair despite having an LVEF > 60% prior to surgery. Current predictive models such as STS-PR…
Rugang Zhang · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $465,225 — Project Summary ARID1A, encoding a subunit of the SWI/SNF chromatin-remodeling complex, is the most frequently mutated epigenetic regulator across human cancers. Most notably, inactivating mutations in ARID1A occur in ~50% of ovarian clear cell carcinomas (OCCC) and ~30% of ovarian endometrioid carc…
Robert F. Kirsch · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2024 — Dr. Kirsch has been a VA RR&D research for 28 years, and a VA RR&D Research Career Scientist since 2007. He has a very active research program and is a leader in both rehabilitation research and academia. His personal research activities focus on restoring shoulder, arm, and hand movements to indivi…
Martha Ann Alexander-Miller · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $721,045 — Influenza virus infection of neonates can lead to life-threatening disease. The rate of LRTI-associated hospitalizations is >4 times higher in children less than 1 year of age compared to those between 1 and 4 years and infants younger than 6 months of age are particularly vulnerable to the developm…