Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Richard L Gallo · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $611,296 — PROJECT SUMMARY (See instructions): This project has sought to understand the functions of the cathelicidin family of antimicrobial peptides in mammalian immunity. Cathelicidins are an evolutionarily conserved gene family, with orthologous genes present in several species. Conservation between famil…
Anna Greenwald · GEORGETOWN UNIVERSITY · 2024 · $531,049 — Project Summary Non-primary visuospatial deficits are common after right-hemisphere (RH) injury, and they are known predictors of long-term disability after stroke. However, compared to impairments of language and motor function, they are less obvious and receive less attention in stroke research, d…
Megan Enfield Vanneman · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 — Background: This CDA will provide me, Megan E. Vanneman, PhD, MPH, with the training and experience to become an independent health services researcher who applies decision science and informatics to improve Veterans’ access to and engagement in high-quality care. To help achieve this goal, I will w…
Nicholas James Brady · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $196,745 — PROJECT SUMMARY/ABSTRACT Despite advances in the development of highly effective androgen receptor (AR)-directed therapies for the treatment of men with advanced prostate cancer, acquired resistance ultimately ensues. Lineage plasticity has been proposed as one mechanism of therapeutic resistance wh…
Pari Vijay Pandharipande · OHIO STATE UNIVERSITY · 2024 · $394,049 — PROJECT SUMMARY/ABSTRACT Our goal is to find the best ways to prevent pancreatic cancer deaths in patients with pancreatic cysts. Recent advances in imaging have led to the detection of innumerable pancreatic cysts that could never be seen before, now visible in >10% of patients who have an MRI and …
CHARLES GINSBERG · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $635,333 — In 2017 the International Diabetes Federation estimated that the worldwide prevalence of diabetes would increase from 415 million in 2015 to 642 million in 2040. Approximately 40% of individuals with diabetes develop diabetic nephropathy (DN). Twenty percent of these individuals do not follow the ty…
TIMOTHY D HARRIS · JOHNS HOPKINS UNIVERSITY · 2024 · $3,071,086 — 1 Project Summary: The BRAIN 2025 Report, with the goal to “produce a dynamic picture of the functioning brain 2 by developing and applying improved methods for large-scale monitoring of neural activity” is directly 3 addressed by this application. The Neuropixels probe (Jun et al., Nature 2017) d…
Erica Carmen Kaye · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $252,084 — PROJECT SUMMARY/ABSTRACT My career goal is to develop an independent research program focused on improving communication for children with advancing cancer and their families. When parents understand prognosis, children with advancing cancer are more likely to receive palliative care and interventio…
CANDYCE H KROENKE · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $636,502 — ABSTRACT Breast cancer (BC) is the most commonly diagnosed cancer and cause of cancer mortality in Asian/Pacific Islander (API) and Hispanic women, the two most rapidly growing minority ethnic groups in the US due to immigration. Once diagnosed, immigrant API women have similar or worse, and immigra…
Sarah Cobey · UNIVERSITY OF CHICAGO · 2024 · $465,284 — PROJECT SUMMARY Individuals’ adaptive immune responses are central to the epidemiology and evolution of influenza and the effectiveness of influenza vaccines. It is therefore surprising that despite nearly 70 years of study, major questions about the immune response to influenza remain unanswered. I…
Katlynn Bugda Gwilt · BOSTON CHILDREN'S HOSPITAL · 2024 · $84,592 — PROJECT SUMMARY The goal of this grant application is to understand how mutations in tetratricopeptide repeat domain 7a (TTC7A) affect formation of the polarized apical membrane; and how these mutations cause human disease. TTC7A loss of function mutations result in severe infantile-onset gastrointe…
David T Evans · UNIVERSITY OF FLORIDA · 2024 · $847,878 — Abstract A reservoir of latently infected cells persists in various anatomical sites in people living with HIV (PLWH), despite effective virological control by antiretroviral therapy (ART). The majority of virally suppressed individuals experience rapid viral rebound upon ART interruption, providin…
Neil C Chi · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $747,916 — Project Summary The heart consists of a multitude of diverse cardiac cell types, including but not limited to cardiomyocytes, cardiac fibroblasts, epicardial cells, endothelial/endocardial cells and smooth muscle cells, which coordinate to sustain cardiac function and circulation throughout the body…
Christopher G. Slatore · PORTLAND VA MEDICAL CENTER · 2024 — Background: VA recommends all eligible Veterans be offered lung cancer screening (LCS) using annual low dose computed tomography (LDCT). VA is working to increase the number of Veterans screened in VA-settings but many of them will continue to receive LCS care in non-VA settings. There are several g…
Sandeep K Mallipattu · NORTHPORT VA MEDICAL CENTER · 2024 — Chronic kidney disease (CKD) is a leading risk factor for cardiovascular disease, with a disproportionate burden on U.S. Veterans. Recent data demonstrates that acute kidney injury (AKI), despite initial renal recovery, is a major risk factor for CKD. The proximal tubule (PT) is the primary target i…
PONCIANO D CRUZ · VA NORTH TEXAS HEALTH CARE SYSTEM · 2024 — PROJECT SUMMARY Melanoma is a significant cause of morbidity and mortality in the U.S. and among military veterans. Having discovered an immune-vascular regulating pathway (DC- HIL/SD4) whose function can be manipulated to treat cancers, we will: (1) dissect its effects on immunity and vascularity i…
Jin Chen · VETERANS HEALTH ADMINISTRATION · 2024 — Project Summary/Abstract Lung cancer is the leading cause of cancer-related deaths in the US and disproportionally affects Veterans. Although targeted therapies for lung adenocarcinoma improve overall survival, no similar advances have been made in lung squamous carcinoma (LUSC), which represents 30…
Carina Marquez · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $675,457 — PROJECT SUMMARY/ABSTRACT The burden of tuberculosis (TB) in children and adolescents is massive and current TB control strategies, even at full scale-up, are insufficient to address it.4,6-8,10 Novel strategies to expand TB control outside of the home and into the community, where children acquire a…
Bahar Shahidi · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $383,229 — Low back pain (LBP) is a complex condition that affects 65-85% of the population, and is the leading musculoskeletal condition contributing to disability in the United States. Seventy-five percent of individuals undergoing treatment for this condition experience suboptimal or poor outcomes in the fo…
GINA R KUPERBERG · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $587,007 — For language comprehension to succeed in noisy and ambiguous environments, the human brain must use contextual information to actively predict upcoming linguistic inputs. Impairments in top-down prediction are thought to contribute to language and communicative dysfunction in a variety of neurodevel…