Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Joseph Piven · WASHINGTON UNIVERSITY · 2024 · $2,543,872 — ABSTRACT The overarching goal of this proposal is to lower the age of detection in autism to early infancy, making presymptomatic (i.e., before the emergence of ASD-specific behavioral features) intervention feasible. Infants with an older autistic sibling have up to a 20% risk of developing autism …
David G Amaral · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $680,570 — Autism Spectrum Disorder (ASD) affects 1-2% of children in the United States. The etiology(ies) and neurobiological underpinnings of autism remains unclear and hence targets for effective medical treatments are rare. While myriad genetic mouse models have been created, and many demonstrate some phen…
Alexander Staruschenko · JAMES A. HALEY VA MEDICAL CENTER · 2024 — The kidneys are highly sensitive to metabolic changes. Metabolic phenotyping uncovered a number of pathways associated with high blood pressure and kidney diseases, which sheds light on the complex pathophysiology of hypertension and associated kidney injury. However, the mechanisms underlying the e…
Frank Wolfgang Albert · UNIVERSITY OF MINNESOTA · 2024 · $631,895 — Project Summary/Abstract Drug and alcohol use and addiction are heritable phenotypes that are leading causes of morbidity and mortality worldwide. Hundreds of loci have now been strongly linked to risk for substance use and addiction, and many more genes remain to be discovered. Studies of impactful…
Emily S Wan · VA BOSTON HEALTH CARE SYSTEM · 2024 — Chronic lung diseases (CLDs), including asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD), cause significant functional limitation and disability and were, collectively, the 4th leading cause of death in the United States in 2019. Veterans are enriched for env…
Christopher Almond · STANFORD UNIVERSITY · 2024 · $1,073,956 — PROJECT SUMMARY/ABSTRACT This collaborative grant application proposes (a) to conduct a multicenter single-arm pivotal clinical trial of the Jarvik 2015 left ventricular assist device (LVAD) as a bridge-to-transplant in 22 hospitalized children with severe heart failure (HF) refractory to medical th…
Robert Folmer · PORTLAND VA MEDICAL CENTER · 2024 — Our previous work has collected normative data for measures of both tinnitus perception and tinnitus functional effects (reactions). Participants with chronic tinnitus, who were not receiving tinnitus-specific intervention, completed tinnitus psychoacoustic measures and tinnitus questionnaires at 0,…
Jonathan Tang · SEATTLE CHILDREN'S HOSPITAL · 2024 · $241,524 — Understanding the process by which animals learn to perform specific actions from rewarding experiences is important for identifying the neural and behavioral patterns that indicate system dysregulation; such knowledge can help lead to the development of diagnostics and therapy for conditions where …
Ya-Chieh Hsu · HARVARD UNIVERSITY · 2024 · $504,905 — Project Summary Skin stem cells are heavily influenced by signals from their niches including different fibroblasts populations. While our ability to isolate and molecularly profile diverse cell types has improved drastically in the past decade, a major roadblock in identifying key genes driving ste…
Jazmin Brown-Iannuzzi · OREGON RESEARCH INSTITUTE · 2024 · $753,259 — ABSTRACT As Americans enter the third year of the COVID-19 pandemic, we are also in a mental health crisis. Emerging adults in particular are experiencing a high prevalence of anxiety, depression, suicidality, and psychosis compared to pre-pandemic levels. A slowed economy, increased social isolatio…
Vincent Tam · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $395,008 — PROJECT SUMMARY/ABSTRACT Secondary bacterial infection following influenza (super-infection) can lead to cytokine storm (an overexuberant immune response) that often leads to pneumonia and death in patients. Our work focuses on the molecular mechanisms by which the immune system returns to homeostas…
GUIDO MARCUCCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $515,745 — Chronic clonal blood disorders such as myeloproliferative neoplasms (MPN) and chronic phase (CP) chronic myelogenous leukemia (CML) may over time transform, respectively, into secondary (s) acute myeloid leukemia (AML) and blast crisis (BC) CML, which are poorly responsive to currently available the…
Alisa Knodle Manning · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $709,961 — Project Summary/Abstract Type 2 diabetes continues to spread globally due to unhealthy environment interacting with genetics. Recent genetic discoveries of >700 variants at >400 loci associated with type 2 diabetes (T2D) and its related quantitative traits (QTs: fasting glucose (FG), insulin (FI) an…
RADHAKRISHNA RAO · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $497,663 — Public radiation exposure due to large-scale radiation incidents is a rising global concern. Gastrointestinal Acute Radiation Syndrome (GI-ARS) is associated with high morbidity and mortality. However, FDA- approved therapeutics for GI-ARS are unavailable. Therefore, outlining the mechanisms of radi…
Cedric Manlhiot · JOHNS HOPKINS UNIVERSITY · 2024 · $122,813 — Project summary Under the current clinical paradigm, the majority of patients sharing a pathology tend to be treated in a similar manner according to clinical guidelines that are based on previously conducted clinical trials combined into meta- analyses. While some situations are amendable to the st…
Ryan E Hibbs · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $638,821 — Project Summary/Abstract Autoimmunity against neuronal receptors causes an array of diseases. Cys-loop receptors are a class of neuronal receptors targeted in autoimmune diseases including myasthenia gravis, autoimmune encephalitis, and autoimmune autonomic ganglionopathy. Myasthenia gravis is the …
Emily Bernstein · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $388,937 — PROJECT SUMMARY Epigenetic deregulation is now widely accepted as a hallmark of pediatric cancer. Mutations and structural alterations of the SWI/SNF-like chromatin remodeler ATRX (Alpha Thalassemia/Mental Retardation, X- linked) have been reported at high frequency in a number of adult and pediatri…
Santosh Kumar · UNIVERSITY OF MEMPHIS · 2024 · $1,132,670 — Primary Investigator: Kumar, Santosh mHealth Center for Discovery, Optimization & Translation of Temporally-Precise Interventions (mDOT) – Overall Abstract: Providing care for patients with chronic diseases is one of the biggest drivers of the nation’s rising healthcare spending. Many of these disea…
BONNIE J MARTIN-HARRIS · NORTHWESTERN UNIVERSITY · 2024 · $183,209 — PROJECT SUMMARY/ABSTRACT The emergence of electronic medical records, large data registries and readily accessible, protected servers have resulted in an explosion of digital information with potentially high clinical impact for improving patient management and outcomes. Big data warehouses that cap…
Zongqi Xia · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $386,508 — PROJECT SUMMARY AND ABSTRACT. The COVID-19 pandemic due to the SARS-CoV-2 infection poses new challenges to the ~3 million persons with multiple sclerosis (PwMS) worldwide. Major knowledge gaps include the extent to which common MS disease modifying therapies (DMTs) modulate the COVID-19 risk and se…