Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Yanning Rui · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $370,651 — PROJECT SUMMARY An intracranial aneurysm (IA) is a bulge or ballooning of the cerebral artery due to weakness in the blood vessel wall. IA rupture causes subarachnoid hemorrhage (SAH), the most life-threatening form of stroke. However, the molecular mechanisms underlying IA pathogenesis are poorly u…
Allan I. Basbaum · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $922,471 — Despite tremendous progress in our understanding of the primary sensory neurons and spinal cord interneuronal circuits that respond to and transmit pain and itch-provoking stimuli, how these stimuli are interpreted by the brain to produce the perceptions of pain and itch are still unclear. To a grea…
Daniel Leif Migdow Suess · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $306,005 — Project Summary/Abstract Enzymes with complex metallocofactors in their active sites catalyze myriad transformations relevant to human health and disease. Understanding their reaction mechanisms requires molecular-level characterization of their resting states and intermediate states, and metal-spec…
Luke Joseph Chang · RUTGERS THE STATE UNIV OF NJ NEWARK · 2024 · $532,023 — Project Summary Social isolation is associated with a host of negative outcomes including increased rates of depression and early mortality. Critically, social isolation can lead to maladaptive choices such as substance use as a coping strategy for negative affect. Importantly, perceived connection …
Koichi Yuki · BOSTON CHILDREN'S HOSPITAL · 2024 · $386,433 — Project Summary/ Abstract Sepsis remains to be associated with a high mortality of 20 to 30% with annual cost of $24 billion, accounting for nearly one-fifth of the total aggregate costs in all the hospitalizations in the United States. Current sepsis management is supportive. Therefore, identifying…
Carla J Berg · GEORGE WASHINGTON UNIVERSITY · 2024 · $515,131 — SUMMARY/ABSTRACT Among the disparities faced by populations in low- and middle-income countries (LMICs) are those related to tobacco use and secondhand smoke exposure (SHSe). Two countries particularly impacted by tobacco use and SHSe are Armenia (AM) and Georgia (GE), which represent the 11th and 6…
James M Otis · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $339,750 — SUMMARY/ABSTRACT Reward-associated cues are unlikely to provoke reward seeking when that behavior is inappropriate, yet cues elicit opioid seeking in patients with opioid use disorder (OUD) when that behavior is unproductive or maladaptive. There is little understanding of how brain systems that can…
Jennifer Lynn Carnahan · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $178,039 — Increasing numbers of patients with Alzheimer’s disease and related dementias (ADRD) are receiving post- hospitalization care in skilled nursing facilities (SNFs). Most will transition from the SNF to home. Although there has been a great deal of attention paid to patients’ transition from the hospi…
Jonathan Wynn · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · 2024 — Disturbances in motivation are major determinants of poor functional outcome in a large number of Veterans with schizophrenia (SCZ) and bipolar disorder (BPD). Motivation is defined as the orienting and energizing impact of prospective rewards on cognition and behavior. Despite their clear public he…
Penny Ann Ralston · FLORIDA STATE UNIVERSITY · 2024 · $522,767 — Program Director/Principal Investigator (Last, First, Middle): Ralston, Penny A. The Health for Hearts United Collaborative Project Summary Cardiovascular disease (CVD) is the leading cause of death in the United States, and disproportionately affects African Americans (AAs) who have the highest rat…
James J Collins · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $460,972 — Schistosomiasis ranks second (behind malaria) as the world’s most devastating parasitic disease. Despite this, treatment relies on a single drug, Praziquantel (PZQ), that has marginal efficacy. This disease is caused by Schistosoma flatworms (schistosomes) that live in the vasculature, producing egg…
MARCO COLONNA · WASHINGTON UNIVERSITY · 2024 · $587,914 — PROJECT SUMMARY B cells have an important pathogenic role in neurological autoimmune disorders, such as multiple sclerosis (MS) and neuropsychiatric systemic lupus erythematosus (NP-SLE), one of the most disabling manifestations of SLE. The relevance of B cells in central nervous system (CNS) autoim…
Richart W Harper · VA NORTHERN CALIFORNIA HEALTH CARE SYS · 2024 — The goal of this resubmitted application is to define signature exhaled breath volatile organic compounds (VOCs) in veterans exposed to toxicants and to develop an effective portable exhaled breath health monitoring system for soldiers at risk of developing respiratory disease. This project will bri…
Keri C Hornbuckle · UNIVERSITY OF IOWA · 2024 · $2,204,080 — SUMMARY: Iowa Superfund Research Program Overall The Iowa Superfund Research Program (ISRP) is a center of research excellence focused on polychlorinated biphenyls (PCBs). PCBs were widely produced in the mid-20th century and used in thousands of products, from common household items to construction…
Richelle J. Cooper · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $354,349 — Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. The ongoing COVID- 19 pandemic has brought into stark relief the importance of emergenc…
Albert Shieh · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $659,999 — PROJECT SUMMARY/ABSTRACT This study endeavors to answer the following, potentially paradigm-changing question: in humans, does gut leak increase during the menopause transition (MT); and if so, does gut leak lead to immune activation, bone mineral density (BMD) decline and fractures? In murine mode…
Elaine I Tuomanen · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $455,000 — Using the pneumococcus as a model, our lab has revealed many features of the biochemical basis of the inflammatory response to bacteria in the brain. The important discovery of this application is the opening of a new area of pathogenesis at the maternal/fetal interface that will inform newly discov…
Richard G Kibbey · YALE UNIVERSITY · 2024 · $730,784 — Ongoing analyses from our laboratory and others have identified novel properties of self proteins, namely posttranslational protein modifications (PTMs) that may be identified as early proteomic and immunologic biomarkers of Type 1 diabetes as well as alter metabolic pathways. An emerging number of …
Deanna L. Mori · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $229,976 — Project Summary Posttraumatic stress disorder (PTSD) affects almost one quarter of military Veterans seeking care from Veterans Administration healthcare facilities. PTSD is associated with many health-related issues, especially chronic musculoskeletal pain, and is increasingly considered a systemic…
Aliza Pham Wingo · VA NORTHERN CALIFORNIA HEALTH CARE SYS · 2024 — Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are among the most prevalent and debilitating psychiatric disorders in U.S. Veterans. They are highly comorbid and have shared genetic susceptibility. Treatments for PTSD or AUD are ineffective in many patients, and comorbid PTSD a…