Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Walter F Boron · CASE WESTERN RESERVE UNIVERSITY · 2024 · $643,803 — Red blood cells (RBCs) play a vital role in gas transport—carrying O2 from the alveolar air to systemic tissues, and CO2 in the opposite direction. Their task is central to many diseases of major public-health relevance, in- cluding including heart failure, pulmonary disease (including COVID-19), va…
Claudia M Nicolae · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $349,812 — Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalized cancer therapies. PARP10 is a poorly characterized member of the PARP family. We previously showed that PARP10 promote…
JASON S DEBLEY · SEATTLE CHILDREN'S HOSPITAL · 2024 · $860,375 — Project Summary: Asthma exacerbations among U.S children result in 640,000 emergency department visits, 280,000 hospitalizations, and 14 million missed school days annually. Type 2 (T2) cytokine-driven inflammation characterizes the most common asthma endotype in children (T2-high) and is associated…
ANN M MOORMANN · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $987,656 — A highly effective malaria vaccine remains the ultimate tool for malaria control and elimination. The front runner is RTS,S/AS01, a recombinant protein comprising portions of Plasmodium falciparum (Pf) circumsporozoite protein (CSP). However, the observed vaccine efficacy to clinical malaria in chil…
Bryan David James · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $575,478 — Project Summary / Abstract The overarching goal of this project is to develop the evidence base around the predictors and consequences of clinical underdiagnosis vs early clinical diagnosis of Alzheimer’s disease and related dementias (ADRD) in healthcare settings. Many older persons who would meet …
Robert Kortum · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2024 · $331,394 — Project Summary/Abstract PI: Kortum, Robert L. Our data show that RTK−SOS1/2−WT RAS signaling is a critical therapeutic target in RAS-mutated cancers. Our objective is to differentiate between those RAS-mutated cancers in which inhibiting RTK−SOS1/2−WT RAS−effector signaling should be part of an ove…
Michael Thomas Eadon · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $631,061 — Project Summary/Abstract Most solid organ recipients are prescribed tacrolimus to prevent rejection and maintain allograft function. The overall goal of this study is to assess the safety of cannabidiol (CBD) when co-administered with tacrolimus. The proposed studies will comprehensively define the …
David James Civitello · EMORY UNIVERSITY · 2024 · $96,950 — RESOURCE COMPETITION DRIVES NATURAL AND REBOUND DYNAMICS OF SNAILS AND SCHISTOSOMES Project summary More than 250 million people are infected with schistosomes, flatworms in the genus Schistosoma, and 20 million humans suffer from severe morbidity due to schistosomiasis. Humans become infected afte…
Todd A Wyatt · OMAHA VA MEDICAL CENTER · 2024 — Pneumonia is one of the leading causes of morbidity and mortality, particularly in older individuals. Importantly, alcohol misuse has been associated with increased pneumonia for over 200 years. While the role of alcohol in bacterial pneumonia susceptibility and severity remains to be fully understo…
EDWARD W YU · IOWA STATE UNIVERSITY · 2024 · $626,007 — PROJECT SUMMARY Bacterial multidrug efflux transporters confer resistance to structurally diverse antimicrobials, which is one of the major causes for clinical treatment failure. Campylobacter jejuni is a major enteric pathogen and has developed various mechanisms for antibiotic resistance. Recently…
Angkana Chaiprasert · PRINCE OF SONGKLA UNIVERSITY · 2024 · $286,869 — PROJECT SUMMARY This grant application is the renewal of the D43TW009522 training program in its second phase for another 5 years. The training program's plan is to strengthen TB research capacity, especially human resources of TB research at collaborating centers in low and middle-income (LMIC) cou…
May Hua · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $448,284 — Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom management, provision of psychosocial support, elicitation of preferences and aiding decision-making. Prior studies have demo…
MELISSA LEWIS · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $131,189 — ABSTRACT American Indians (AI) have the largest prevalence of cardiovascular disease (CVD) in the nation with double the prevalence compared to non-AIs. Programs developed and implemented in the general population to prevent CVD may not be appropriate or effective for AI populations due to unique en…
Francois St-Pierre · BAYLOR COLLEGE OF MEDICINE · 2024 · $589,350 — PROJECT SUMMARY/ABSTRACT Fluorescent proteins are ubiquitous reagents in the biomedical sciences for reporting gene expression, protein and nucleic acid localization, cell shape, and cellular activity. However, fluorescent proteins (FPs) become progressively dimmer — they photobleach — with repeated…
ERIC F MOOSHAGIAN · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $415,766 — Abstract The central goal of this proposal is to understand the neural systems subserving the decision to use the left or right hand1 – a simple choice that is central to our daily functions. Here we focus on parietal mechanisms of limb selection. Despite it being one of the most common decisions fa…
David Fiellin · YALE UNIVERSITY · 2024 · $714,133 — Project Abstract Alcohol Use Disorder (AUD) is a chronic relapsing illness in which alcohol withdrawal symptoms (AW) are associated with greater treatment failure risk and higher rates of relapse and alcohol intake. Efficacy of current approved medications in AUD are modest, and none have been shown…
SETH R BORDENSTEIN · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $402,500 — Project Summary: Wolbachia are a genus of endosymbiotic bacteria that comprise a promising, cost-effective tool to curb Zika and dengue arboviral transmission based on two key facets. First, Wolbachia block pathogenic RNA viruses by inhibiting their replication in arthropods. Second, Wolbachia selfi…
Olena Korvatska · UNIVERSITY OF WASHINGTON · 2024 · $759,146 — Alzheimer's disease (AD), the most frequent cause of age-related dementia, constitutes a serious burden for the US health system and economy. In the absence substantial preventative or disease-modifying treatments, AD frequency is increasing as the lifespan increases. Age and genetic predisposition …
Ahmed Abdel Latif · VETERANS HEALTH ADMINISTRATION · 2024 — PROJECT SUMMARY/ABSTRACT Obesity is approaching an epidemic state in the United States and is strongly associated with a higher risk of heart failure with preserved ejection fraction (HFpEF), a major cause of morbidity and mortality in obese individuals. In the VA population, HFpEF accounts for appr…
Louis J. Dell'Italia · BIRMINGHAM VA MEDICAL CENTER · 2024 — Heart failure (HF) with preserved left ventricular ejection fraction (HFpEF) caused by hypertension is a leading cause of morbidity and mortality and escalating health care costs. As opposed to heart failure with reduced ejection fraction (HFrEF), the heart cannot properly fill, resulting in left ve…