Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Amanda L. Lewis · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $570,002 — PROJECT SUMMARY/ABSTRACT: One-third of women in the U.S. have bacterial vaginosis (BV), a condition associated with greater risks of reproductive tract infections and preterm birth. BV is characterized by loss of lactobacilli and polymicrobial overgrowth of diverse potential pathogens, including Gar…
DUSTIN J. TYLER · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2024 — “… to feel my wife’s hand,” he said with tears in his eyes. This was our subject’s response when he was asked what he wanted to get from participating in our study. His five simple words brought a tectonic shift in my thinking and provided the deep purpose to my work. Patient’s do not need fancy tec…
Paula Bourke · THOMAS JEFFERSON UNIVERSITY · 2024 · $646,298 — ABSTRACT Orthopaedic infection is life-threatening and current treatments are only sparingly successful. Despite aggressive peri-operative antibiotic treatments, 1.5% of knee revisions, 0.7 to 11.9%, of spinal infections (depending on the complexity of the procedure) and up to 27% of open fractures …
Stephen K Dolan · CLEMSON UNIVERSITY · 2024 · $150,000 — Project Summary Aspergillus fumigatus (Af) is the most common and life-threatening airborne opportunistic fungal pathogen. Investigations into Af pathogenesis have focused primarily on mono-species infections. The impact of co- infecting microbes on Af physiology during infection remains an understu…
Yiqin Du · UNIVERSITY OF SOUTH FLORIDA · 2024 · $456,500 — Project Summary Glaucoma is a leading cause of irreversible blindness throughout the world and the second leading cause of blindness overall in the USA. Elevated intraocular pressure (IOP) and aging are the most important risk factors for most forms of glaucoma. IOP level is highly dependent on the …
VIKAS DUDEJA · BIRMINGHAM VA MEDICAL CENTER · 2024 — Project Summary Pancreatic cancer (PDAC) is the 3rd most common cause of cancer-related mortality in the US. Our veterans and military personnel bear significant brunt of this disease. One of the major obstacles in devising effective treatment strategies against PDAC is the incomplete understanding …
Lorne J Hofseth · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $323,796 — PROJECT SUMMARY Affecting upwards of 4 million people in North America and Europe, with an economic burden of $30 - $45 billion, Inflammatory Bowel Diseases (IBDs) are debilitating, significantly affect life-style, and carry a high colon cancer risk. Because conventional treatment outcomes are mode…
LUISA N BORRELL · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $700,325 — PROJECT SUMMARY Asthma is the most common chronic disorder of children, with an estimated 300 million cases worldwide and with significant increases in incidence since the early 1980s. In the United States (U.S.), asthma prevalence, morbidity, mortality, and drug response vary substantially among ra…
Jeffery Micheal Tharp · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $249,000 — PROJECT SUMMARY Bicyclic peptides are conformationally constrained peptides comprised of two macrocyclic rings. Owing to their increased rigidity, bicyclic peptides can bind to protein targets with greater affinity and selectivity than their linear and monocyclic counterparts. As a result, these mol…
Charles B. Chang · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $10,000 — PROJECT SUMMARY / ABSTRACT We seek five years of funding to enhance diversity and accessibility at the Boston University Conference on Language Development (BUCLD), which will take place at Boston University each year around the first weekend in November. Now in its 46th year, the BUCLD is internati…
Mostafa Zamanian · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $383,923 — Project Summary Parasitic nematodes infect over 1.5 billion humans. Control of this poverty-associated global health burden relies almost entirely on the administration of a small number of anthelmintic drugs. The prospects of anthelmintic resistance and the sub-optimal nature of these drugs in many…
OLGA ANCZUKOW-CAMARDA · JACKSON LABORATORY · 2024 · $527,984 — SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a specific cell at a specific time point. Aberrantly spliced isoforms can impact every one of the hallmarks of cancer, incl…
Ayyalusamy Ramamoorthy · FLORIDA STATE UNIVERSITY · 2024 · $396,250 — Abstract Functional reconstitution of membrane proteins has been the major roadblock for the application of NMR and other biophysical techniques to investigate their high-resolution dynamic structures in a native membrane environment. In this application, we propose to develop approaches to enable h…
Kyle Harrington Flippo · IOWA CITY VA MEDICAL CENTER · 2024 — In the United States alcohol use disorder (AUD) affects ~15% of adults. While those numbers alone are striking, patients diagnosed with post-traumatic stress disorder (PTSD) are 3 times more likely to develop AUD compared to the population at large. This relationship is even more worrisome in Vetera…
THOMAS G BLANCHARD · NATIONAL DISEASE RESEARCH INTERCHANGE · 2024 · $2,343,364 — Program Director/Principal Investigator (Bell, Thomas, J.): Project Summary: Accelerating scientific discoveries across the entire spectrum of pediatric research requires advancing our current understanding of the unique molecular profiles and physiologies in all healthy tissues across the human bod…
Adrienne G Randolph · BOSTON CHILDREN'S HOSPITAL · 2024 · $1,126,202 — ABSTRACT Influenza virus is a persistent global menace that every year infects an estimated 5-10% of adults and 20-30% of children worldwide causing over 500,000 influenza-related deaths. Most annual influenza infections are in the very young, the elderly, and in individuals with chronic health cond…
Christine C Johnson · HENRY FORD HEALTH SYSTEM · 2024 · $2,818,591 — This application builds on the findings of our initial P01 designed to examine relationships between environmental factors, especially pets, the infant gut microbiota and pediatric allergic asthma. We have shown that: 1) dogs alter the microbial composition of dust in homes, 2) children born into ho…
SHARAD KHARE · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · 2024 — Abstract Colorectal cancer (CRC) is the leading cause of cancer-related death in the United States. Sprouty2 (Spry2) is an endogenous suppressor of receptor tyrosine kinase (RTK)/Ras/Mitogen Activated Protein Kinase (MAPK) signaling pathways. The objectives of this study are: 1. To assess requiremen…
Karin Swartz · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · 2024 — The objective of this proposal is to decipher the mechanistic role of the pro-inflammatory cytokine IL-12 and its downstream effector molecules in mediating cytotoxicity and inflammation after spinal cord injury (SCI), a severe condition with devastating consequences for the neurological function an…
John Kablan · INNOVATIVE DESIGN LABS, INC. · 2024 · $1,249,991 — Project Summary/Abstract Proposed is a sleep monitoring system specifically designed for care providers of persons with Alzheimer’s disease and Alzheimer’s Disease Related Dementias (AD/ADRD) to monitor sleep disturbances and trends. Significance: Studies indicate that approximately 1 in 3 patients …