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9873 documents

International Zebrafish Conference

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Tatjana Piotrowski · STOWERS INSTITUTE FOR MEDICAL RESEARCH · 2024 · $15,000 — PROJECT SUMMARY We propose a series of five annual International Zebrafish Conferences rotating between locations in the US/Canada, Europe and Asia-Pacific that discuss progress made using zebrafish as a model organism to study vertebrate development, homeostasis, and disease. These conferences, to …

Development and Validation of a Telehealth Strategy for Routine Detection of Cognitive Impairment in Primary Care: The MyCog Mobile Assessment

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

CINDY J. NOWINSKI · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $760,331 — PROJECT SUMMARY Our objective is to widely implement and evaluate a user-centered, scalable, telemedicine - linked strategy for the routine detection of cognitive decline during the Annual Wellness Visit. Cognitive impairment is most prevalent among adults 65 and older, yet less than half of cases a…

Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

KELLY J HUNT · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $481,842 — PROJECT SUMMARY Nationally, South Carolina (SC) ranks among the worst for poor pregnancy outcomes and high maternal and infant mortality rates, with vast racial/ethnic disparities present. Infection with the novel SARS-CoV-2 during pregnancy has been associated with pregnancy complications and poor …

Neuromodulatory rehabilitation for respiratory motor function in individuals with chronic spinal cord injury

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Alexander Vladimirovich Ovechkin · UNIVERSITY OF LOUISVILLE · 2024 · $368,666 — Project Summary/Abstract Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this research is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care. Our p…

Baseline pRescription According to Direct from Sputum Sequencing and TArgeted drug Concentration Strategy (BRASS TACS)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jeffrey Tornheim · JOHNS HOPKINS UNIVERSITY · 2024 · $639,787 — Project Summary Tuberculosis is the bacterial infection that kills the most people worldwide, especially in India, which has the highest burden in of multidrug-resistant tuberculosis (MDR-TB) in the world. Delays in adequate treatment due to slow diagnostic tests and the usual one-size-fits-all MDR-…

Enhancing Nurse Practitioner Primary Care Delivery to Address Social Determinants of Health and Reduce Health Disparities: A mixed-methods national study

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Lusine Poghosyan · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $804,074 — More than 80% of adults aged 65 and older in the United States have at least one chronic health condition. Racial and ethnic minorities suffer more. They often lack high quality care and use hospitals and emergency departments (EDs) for routine care. Where minorities reside and receive care contribu…

Characterization of the SARS-CoV-2-mediated piracy of p38ß

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Christina Higgins · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $48,974 — COVID-19 has resulted in a significant burden on the human population following the emergence of SARS- CoV-2. Since the discovery of SARS-CoV-2 in 2019, millions have succumbed to infection due to an imbalanced host response orchestrated by the biology of the virus. Characterization of the interacti…

Complex systems approaches to identify policy levers to reduce racial/ethnic disparities in diet and obesity in cities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

AMY H. AUCHINCLOSS · DREXEL UNIVERSITY · 2024 · $562,340 — High rates of food insecurity and unhealthy diets – including overconsumption of highly-processed, unhealthy foods that are cheaper than their healthier, minimally processed counterparts -- are remarkably consistent across U.S. cities, particularly in many Black, Latino and low-income neighborhoods …

Disparities in utilization and delivery outcomes for women with perinatal mood and anxiety disorders (PMAD): groundwork for state policymaking

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kara Zivin · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $633,159 — Project Summary/Abstract This study directly responds to NIMHD Program Announcement for Health Services Research on Minority Health and Health Disparities (PAR-20-310). Perinatal mood and anxiety disorders (PMAD), which include depression and/or anxiety in the year before and/or after delivery, are…

CSHL The Biology of Genomes Conference (2023-2027)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

DAVID J. STEWART · COLD SPRING HARBOR LABORATORY · 2024 · $60,185 — THE BIOLOGY OF GENOMES Cold Spring Harbor Laboratory, Cold Spring Harbor, New York May 9 – 13, 2023 May 7 - 11, 2024 May 6 – 10, 2025 May 5 – 9, 2026 May 11 – 15, 2027 Five successive annual conferences on THE BIOLOGY OF GENOMES (scheduled for each May of 2023-2027) will be held at Cold Spring …

Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Rebecca Saracino · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $174,699 — Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ≥65 years, ≥1-year post- treatment) have clinically significant depression. Presently, 64% of cancer survivors are ≥65 years old, and that number will increase to 73% by the year 2040. Thus, the number of depressed OACS …

Mentoring investigators to improve health outcomes among persons with opioid and tobacco use disorder

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Shadi Nahvi · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $194,400 — ABSTRACT Reductions in the health burden of tobacco and other substance use and of overdose mortality have not been equitably distributed. A minority of persons with substance use disorder (SUD) access treatment. To improve the equity in the delivery of evidence-based treatment of opioid-, tobacco- …

Eliminating racial disparities in severe maternal morbidity by addressing hypertension in the year after delivery

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Janet M Catov · MAGEE-WOMEN'S RES INST AND FOUNDATION · 2024 · $551,784 — ABSTRACT The increasing rate of severe maternal morbidity and mortality events in the U.S. disproportionately burdens Black women. Black women are 3 to 4 times more likely than white women to suffer or die from complications during or after pregnancy. Hypertensive disorders of pregnancy (HDP) (e.g.,…

Evaluation of Operation Safer Ground: A Community-Level Rapid Housing Intervention for People Vulnerable to COVID-19.

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MEGAN L COMFORT · RESEARCH TRIANGLE INSTITUTE · 2024 · $512,963 — PROJECT SUMMARY/ABSTRACT The public health crisis engendered by the coronavirus (COVID-19) pandemic has fueled unprecedented efforts to address the risk of infection and transmission among vulnerable populations, including provision of non-congregate housing to people experiencing homelessness. The …

Testing a very low-carbohydrate diet version of the Diabetes Prevention Program to reduce risk factors for type 2 diabetes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Laura Saslow · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $328,977 — ABSTRACT One-third of U.S. adults have prediabetes and are at high risk of developing type 2 diabetes and its devastating health consequences. The landmark Diabetes Prevention Program (DPP) trial demonstrated that a resource- intensive, one-on-one program combining diet and physical activity changes…

HIV-1 membrane fusion and inhibition

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2024 · $772,175 — Summary Virus entry begins with the first encounter between the virus and the cell surface and ends with delivery of the contents of the virus into the host cell. HIV-1 membrane fusion is the first key delivery step, mediated by the virus-encoded envelope glycoprotein [Env; trimeric (gp160)3 cleaved…

Individualizing Steroid Use in Pneumonia

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Yewande Odeyemi · MAYO CLINIC ROCHESTER · 2024 · $169,020 — PROJECT SUMMARY/ABSTRACT Pneumonia is the leading infectious cause of death worldwide. While inflammation is a hallmark pathologic feature of pneumonia, the use of corticosteroids to blunt the profound inflammatory response remains undefined. Decades of studies in heterogeneous populations failed to…

Structure-based Vaccine Design for CCHFV

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kartik Chandran · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $428,507 — Project Summary/Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) causes a life-threatening tick-borne disease in humans. The disease presents as a severe form of hemorrhagic fever with a case fatality rate of 10–40%. CCHFV outbreaks have spanned a wide geographic area ranging from Western and …

Addressing Loneliness in Primary Care Patients on Chronic Opioids to Prevent Opioid Misuse

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sebastian Tong · UNIVERSITY OF WASHINGTON · 2024 · $272,125 — PROJECT SUMMARY Patients with chronic pain on opioids frequently experience loneliness, which is associated with poorer health outcomes and higher risks for opioid misuse and opioid use disorder. Given that almost half of opioids are prescribed in primary care, a critical need exists for the develo…

Evaluation and Optimization of a Just-in-Time Messaging Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration Among At-Risk Young Adult Men and Women

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Cynthia A. Stappenbeck · GEORGIA STATE UNIVERSITY · 2024 · $577,426 — PROJECT SUMMARY Young adult men and women perpetrate intimate partner violence (IPV) at high rates. A summary of over 30 years of research concludes that alcohol is a causal factor of IPV, particularly acute alcohol intoxication, highlighting the critical need for interventions delivered proximally …