Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Joana Almaca · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $368,400 — ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While respiratory failure is still the most common cause of mortality in COVID-19 patien…
Megan Evelyn Barefoot · GEORGETOWN UNIVERSITY · 2024 · $53,974 — ABSTRACT Liquid biopsy applications are rapidly emerging as a minimally invasive approach to collect system-wide representative analytes for genomic monitoring of physiologic and disease-related changes. Dying cells release fragmented DNA into the circulation, referred to as cell-free DNA (cfDNA). D…
Alan Teo · PORTLAND VA MEDICAL CENTER · 2024 — Background: This is a time of unprecedented loneliness and social isolation. Loneliness in particular is a powerful predictor of suicidal ideation, suicide attempts, functional decline, and death. Loneliness can and should be addressed by health systems. Due to risk for loneliness and negative healt…
Cathy Ann Alessi · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · 2024 — Background: The most frequently diagnosed sleep disorder among older Veterans is obstructive sleep apnea (OSA), which is associated with serious adverse effects on health, quality of life and survival. Positive airway pressure (PAP) is recommended as first-line treatment (particularly for moderate t…
Cynthia McMillen · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $124,838 — PROJECT SUMMARY/ABSTRACT Emerging infectious diseases pose a significant threat to human and agricultural health; therefore, it is imperative that we take a proactive approach toward understanding virus and host factors that are associated with infection and pathogenesis. Many bunyavirus infections,…
Donna L. Farber · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $807,646 — PROJECT SUMMARY Immune system development during infancy and childhood sets the stage for a lifetime of protective immunity. Infants and children are known to be more susceptible to ubiquitous respiratory and mucosal pathogens for which adults have prior exposures. However, our recent experience in …
Helen M. Dooley · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $228,712 — PROJECT SUMMARY SARS-CoV-2, a betacoronavirus, is the etiologic agent of the ongoing COVID-19 pandemic. In response, worldwide efforts have led to the rapid development of multiple vaccine candidates that have shown efficacy in controlled clinical trials and effectiveness in the general population.…
Christopher James Kennedy · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $181,346 — Background: The United States is experiencing a crisis in mental health care, in which long-term shifts towards the emergency department (ED) for psychiatric treatment have been exacerbated by the COVID-19 pandemic – reduced inpatient hospitalization capacity, delayed outpatient appointments, extend…
Raeanne Cristine Moore · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $595,646 — Today, 20% of adolescents and 26% of young adults have a diagnosable internalizing (e.g. anxiety, depression) or externalizing problem (e.g. impulsivity, aggression, conduct disorders). Neurodevelopmental disabilities and mental health disorders in adolescents and young adults have increased over th…
Frederic D Bushman · UNIVERSITY OF PENNSYLVANIA · 2024 · $1,529,954 — SUMMARY – mVACS PROGRAM Clostridioides difficile is the most reported nosocomial pathogen in the United States and a major public health threat worldwide. Challenges in treating infections with conventional antibiotics and increasing rates of recurrent infection underscore the need for new intervent…
Stanley Perlman · UNIVERSITY OF IOWA · 2024 · $656,039 — Abstract SARS-CoV-2, the cause of COVID-19, continues to cause widespread infection and morbidity, but death rates have decreased as most of the world has either been infected or vaccinated or both. However, at the same time, it has become clear that many patients have developed long term sequelae. …
KATHERINE MCGONAGLE · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $701,537 — Project Summary/Abstract The Panel Study of Income Dynamics (PSID) is a longitudinal, nationally representative survey of US fami- lies that began in 1968. With data collected on the same families and their descendants for 42 waves over 53 years, plus two major immigrant refresher samples in 1997–1…
SCOTT J. HULTGREN · WASHINGTON UNIVERSITY · 2024 · $2,238,702 — PROJECT SUMMARY/ ABSTRACT: Antibiotic-resistant bacterial infections that are no longer sensitive to our life saving antibiotic arsenal are a looming catastrophe and like the recent COVID-19 crisis, will have dire consequences for human health if we are not prepared. This proposal leverages basic sc…
Melinda J Buntin · VANDERBILT UNIVERSITY · 2024 · $812,584 — PROJECT SUMMARY Schools face rising mental health needs among children that have been exacerbated by social isolation, increased economic stress, and reduced societal supervision during the COVID-19 pandemic. U.S. public schools are the most common institutional entry point to mental health services…
THOMAS S. KUPPER · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $993,763 — Respiratory viral pathogens have been responsible for major pandemics over the past two centuries with extraordinary human and economic cost. While most vaccines have focused on antibody neutralization of virus, there has been growing interest in targeting CD8 T cell immunity for more durable protec…
Steven W. Brose · SYRACUSE VA MEDICAL CENTER · 2024 — Spasticity is a debilitating condition in people with upper motor neuron disorders that interferes with an individual’s activities of daily living and sleep. Spasticity can lead to loss of body control and balance resulting in falls, pressure injury of the skin, contractures, and pain. Spasticity hi…
Yvette C Paulino · UNIVERSITY OF GUAM · 2024 · $576,517 — PROJECT SUMMARY Historically, data on Native Hawaiians and Pacific Islanders (NHPI) have been aggregated with Asians thereby masking disparities across this diverse group. Recent disaggregation of NHPIs in health data sets, such as the National Health Interview Survey (NHIS) in the United States (U…
WILLIAM M GEISLER · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $323,100 — PROJECT SUMMARY and ABSTRACT Infectious diseases continue to have a major impact on global health. Clinician-investigators have an important role in addressing infectious diseases through research whose findings can advance the development of new diagnostic, treatment, and prevention strategies. How…
Anthony W.G. Burgett · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $397,764 — The current COVID-19 crisis starkly illustrates the need to develop new modalities for the therapeutic treatment of pathogenic single-stranded RNA (ssRNA) viruses, including against novel viruses that have yet to emerge. Human oxysterol-binding protein (OSBP) has recently been determined to be a cri…
Carmen Giurgescu · UNIVERSITY OF CENTRAL FLORIDA · 2024 · $655,741 — PROJECT ABSTRACT Preterm birth (PTB; <37 weeks gestation) is the leading cause of infant mortality among Black infants. Maternal chronological age has long been used to assess risk for PTB; however, chronological age assumes that individuals age at similar rates and does not capture the inter-indivi…