Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Qizhi Gong · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $593,306 — RESEARCH SUMMARY Sudden-onset of olfactory loss has been recognized as a common COVID-19 symptom. The mechanism of COVID-19 related olfactory dysfunction is unknown. Whether the degree of olfactory deficit is indicative of any long-term neurological diseases in COVID-19 has not been evaluated. Recen…
JAMES E KIRBY · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $216,125 — Project Summary SARS-CoV-2 RT-PCR assays, one of the two major testing modalities used for diagnosis of COVID-19, are inherently quantitative. This has led to use of cycle threshold values for determining (a) if a tested individual remains infectious; (b) whether therapeutic approaches are working i…
HARRY F NOLLER · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2024 · $765,988 — Project Summary This project focuses on understanding the molecular mechanisms underlying the coupled translocation of mRNA and tRNAs during protein synthesis. It includes the important related problems of how the translational reading frame is preserved (or shifted) and how the ribosomal helicase …
Kabayam M Venkat Narayan · EMORY UNIVERSITY · 2024 · $2,211,138 — PROJECT SUMMARY / ABSTRACT (Overall) Precision-CARRS will revolutionize the cardiovascular disease (CVD) prevention and care paradigm from imprecise prediction with focus on late stage disease to personalized and precise prediction with improved understanding of early-stage disease to maintain cardi…
Y. S. Prakash · MAYO CLINIC ROCHESTER · 2024 · $670,051 — The impact of acute airway inflammation is mediated by pro-inflammatory cytokines (e.g., TNFα), and underlies a number of respiratory diseases. A fundamental question is why are some individuals more susceptible than others to the negative impact of airway inflammation. We will explore a novel homeo…
ROBERT E GERSZTEN · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $439,554 — PROJECT SUMMARY/ABSTRACT There is mounting concern that patients hospitalized with COVID-19 experience unexpectedly high rates of cardiac and vascular events. Identifying which patients are at highest risk for COVID-19-related cardiovascular events and delineating how these events affect short- and …
Priscilla Simon Redd · CHEMEDIMMUNE, INC. · 2024 · $320,597 — Project Summary Lung metastasis is the 2nd most common metastasis and accounts for 30% of all metastatic diseases in human cancer patients. Patients with lung metastases have a very short survival time. For example, the 5- year survival rate for colorectal cancer patients with lung metastases, if l…
Nik Sherina Hanafi · UNIVERSITY OF MALAYA · 2024 · $244,134 — PROJECT SUMMARY In order to ensure more expertise in research ethics to support the rapid increase in research activities taking place in Malaysia, the Master of Health Research Ethics (MOHRE) program at Universiti Malaya (UM) was developed in collaboration with the Johns Hopkins Berman Institute of…
Kerry Evers · PRO-CHANGE BEHAVIOR SYSTEMS, INC. · 2024 · $324,381 — Belonging is an integral part of the human experience and a paramount human need and motivation. A robust sense of belonging can serve to improve mental and physical health, as well as resilience. Thwarted belonging— the antithesis of belonging—and the feelings/experiences it foments (e.g., alienati…
Arantzazu Eiguren Fernandez · AEROSOL DYNAMICS, INC. · 2024 · $572,439 — Project Summary Respiratory infections are the most common reason for doctor visits and the third leading cause of deaths. Viruses are the causative agents of most respiratory tract infections. Knowledge of the transmission modes for pathogenic respiratory viruses is critical for improving mitigatio…
Daniel Kim · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $741,023 — Project Summary/Abstract: Post-acute sequelae of SARS-CoV-2 (PASC), which occurs up to 30% of COVID- 19 infections, has emerged as a significant healthcare issue in the US. The mechanisms, diagnostic imaging tests, and therapies for persistent symptoms caused by PASC remain unknown. The CDC describe…
Stanley Xu · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $797,195 — PROJECT SUMMARY/ABSTRACT Despite the success of the unprecedented COVID-19 vaccine rollout in the U.S., vaccine hesitancy is evident, partly due to safety concerns about severe adverse events (SAEs) surrounding the novel technology of mRNA COVID-19 vaccines and reports of blood clots following recei…
Rafi Ahmed · EMORY UNIVERSITY · 2024 · $1,864,381 — The overarching goal of our CCHI application on “Vaccine and Infection Induced Immunity in the Young and Aged” is to address fundamental issues about innate and adaptive immunity in humans to infection and vaccination. Our proposal is focused around a large cohort of > 700 COVID-19 patients that we …
Beatriz Mateo-Victoriano · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $48,974 — Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths with a 5-year survival rate of 12%. Over 90% of PDAC is driven by oncogenic KRAS, however inhibitors targeting KRAS have been unsuccessful in the clinic thus far. Targeting oncogenic vulnerabilities is a key…
Sarah Kate Nyquist · J. DAVID GLADSTONE INSTITUTES · 2024 · $69,080 — PROJECT SUMMARY The Centers for Disease Control recommends breastfeeding for the first six months of an infant’s life due to significant long term health benefits for the infant and breastfeeding parent. Beyond meeting the nutritional needs of the infant, human milk is a dynamic fluid with compositi…
TERRY L. SHEPPARD · KEYSTONE SYMPOSIA · 2024 · $16,500 — ABSTRACT Support is requested for a Keystone Symposia conference entitled Delivery of Nucleic Acid Therapeutics, organized by Drs. Daniel Siegwart and Kathryn Whitehead. The conference will be held in Banff, Alberta, Canada from January 22-25, 2024. This conference will bring together world-renowned…
Benjamin James Wylie · TEXAS TECH UNIVERSITY · 2024 · $428,400 — Inward-rectifier K+ (Kir) channels and G protein-coupled receptors (GPCRs) are membrane proteins that are regulated by cholesterol and anionic lipids found in their native membranes. We will use solid-state NMR (SSNMR) to study proteins with functional lipids in bilayer environments ranging from pro…
Marisa L. Zallocchi · CREIGHTON UNIVERSITY · 2024 · $491,052 — ABSTRACT. An organism’s perception of its surrounding environment depends on the sensory function. Neurosensory cells from the inner ear are involved in key biological processes associated with hearing and balance. To be able to achieve their function these cells depend on a complex array of membran…
Daniel David BUCHANAN · UNIVERSITY OF MELBOURNE · 2024 · $1,619,489 — PROJECT SUMMARY / ABSTRACT The international, multi-site Colon Cancer Family Registry has established a cohort of approximately 37,400 colorectal cancer cases and their relatives, who are at increased risk of colorectal and other cancers, from over 10,800 families from the USA, Canada, and Australia…
Jean R Guglielminotti · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $369,826 — The long-term goal of the proposed research project is to improve the health of minoritized racial and ethnic birthing people by reducing racial and ethnic disparities in severe maternal morbidity and maternal mortality. Specifically, the proposed research project will assess the effectiveness of 3 …