Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Steven J Shoptaw · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $2,361,051 — ABSTRACT - OVERALL The Center for HIV Identification, Prevention, and Treatment Services (CHIPTS) proposes an HIV/AIDS research agenda aimed to reduce HIV transmissions. CHIPTS promotes science, networking, and capacity building to aid viral suppression for people with HIV (PWH) and reduces HIV infe…
Hideki Aihara · UNIVERSITY OF MINNESOTA · 2024 · $619,646 — Abstract Viruses are a major threat to human health. Our laboratory uses various structural biology techniques to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. One area of our major interest is retroviral integration, a critical step in the lifecycle o…
MARK ROBERTS LOONEY · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $898,236 — Project Summary The adult lung continues to amaze in terms of its complexity and function from the discovery of new cell types to the understanding of new functions of existing cells and molecular pathways operating during homeostasis and injury. Never has lung biology received more attention as dur…
Hanora Anne Marie Van Ert · UNIVERSITY OF IOWA · 2024 · $40,604 — Project Summary/Abstract During pregnancy, viral infections in the mother may have catastrophic effects on her health, or on the viability of the developing fetus. Recently, emerging pathogen outbreaks such as those involving Zika Virus (ZIKV), SARS-CoV-2 or Ebola Virus (EBOV) have highlighted how …
DEV PRIYA ARYA · NUBAD, LLC · 2024 · $998,585 — The world is rapidly heading towards a pre-1940’s scenario when it comes to fighting infectious disease. Antimicrobial resistance is a growing problem on a global scale, greatly hampering our abilities to quell worldwide epidemics such as influenza, SARS, COVID-19, tuberculosis and malaria, as well …
Xiaorong Lin · UNIVERSITY OF GEORGIA · 2024 · $217,673 — Cryptococcus neoformans and C. gattii cause life threatening cryptococcal meningoencephalitis, the most common fungal infection of the central nervous system in the world today. The 12-month mortality rate for individuals with cryptococcal meningoencephalitis is 60% even with the current antifungal …
MAUREEN C FERRAN · UNIVERSITY OF ROCHESTER · 2024 · $185,620 — Project Summary Fulfilling the promise of modern systems biology and grasping the underlying complexity of biological systems requires a foundation built upon the development of high-throughput functional genomic approaches capable of generating large datasets. Large scale sequencing efforts reveal …
Akihiro Nishi · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $134,811 — PROJECT SUMMARY (ABSTRACT) Contact network epidemiology is a compelling epidemiologic framework that aims to model dynamic interactions of people over their social networks in order to track infection cascades, especially for communicable diseases. Network-based simulations in contact network epidem…
Zhenming Xu · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $444,851 — PROJECT SUMMARY – IL-27-producing B cells in the antibody response Built on our novel findings that B cells can be induced to express high levels of IL-27 (IL27p28/EBI3 heterodimer), this proposal will explore molecular and cellular mechanisms underlying the role of IL-27 and IL-27-producing B cells…
WANDA PHIPATANAKUL · BOSTON CHILDREN'S HOSPITAL · 2024 · $2,250,000 — Project Summary/Abstract Asthma is the #1 chronic disease in childhood: prevention is an unmet need and pressing priority. We are conducting the first randomized, double-blind, placebo controlled trial in 200 high risk children 2-3 years of age to determine whether 2 years of treatment with omalizum…
Gary Fanger · RISE THERAPEUTICS, LLC · 2024 · $984,405 — PROJECT SUMMARY Acute respiratory distress syndrome (ARDS) is a severe life-threatening complication that can be caused by viral infection. The disease is characterized by cytokine-driven hyperinflammation and leukocytes count changes. The innate immune response has been linked to ARDS immunopathoge…
NICHOLAS P CIANCIOTTO · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $189,810 — PROJECT SUMMARY Gram- Stenotrophomonas maltophilia (Sm) is an emergent, multi-drug resistant pathogen. Sm infection occurs throughout the body but is most often manifest as pneumonia. Sm is notable in cystic fibrosis (CF) patients, often heightening risk of lung exacerbations, and its significance i…
Jacquelyn P Kulinski · MEDICAL COLLEGE OF WISCONSIN · 2024 · $551,977 — Abstract: Sedentary behavior is becoming increasingly prevalent with the expansion of a ‘work from home’ culture, most recently driven by the COVID-19 pandemic. We now spend more time sitting than in all other activities combined. This increased chair dependency, including a reduction in occupationa…
JOSEPH P MIZGERD · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $805,021 — Pneumonia causes adverse outcomes including hospitalization, intensive care, and death. Host response is pivotal, with immune activities and cell dysfunctions responsible for pathophysiologies including but not limited to excessive microbial growth, alveolar flooding, and septal destruction. Many di…
Melanie Daniela Hingle · UNIVERSITY OF ARIZONA · 2024 · $257,243 — In 2020, more than 38.5 million (10.5%) U.S. households were without reliable access to sufficient quantities of affordable, nutritious food due to limited money or other resources. Food insecurity, poor nutrition, and economic disadvantage are critical social determinants of health that contribute …
Houjian Cai · UNIVERSITY OF GEORGIA · 2024 · $184,222 — Summary/Abstract SARS-CoV-2 has caused the deaths of millions of people globally. Effective antiviral therapeutic treatment options are urgently needed. CRISPR-mediated genome editing has provided a very promising avenue for treatment of a variety of genetic diseases. Particularly, the CRISPR-Cas13 …
Vijayakanth Pagadala · GLYCAN THERAPEUTICS CORPORATION · 2024 · $747,280 — The goal of this proposal is to develop dekaparin, a synthetic glycan, to replace animal-derived low molecular weight heparins (LMWHs). LMWHs are partially depolymerized natural products of heparin, which are isolated from porcine intestine. A worldwide distribution of contaminated heparin in 2007 w…
Guang-Shing Cheng · FRED HUTCHINSON CANCER CENTER · 2024 · $739,186 — PROJECT SUMMARY/ABSTRACT Bronchiolitis obliterans syndrome (BOS) is the most severe manifestation of chronic graft-versus-host disease (cGVHD) in survivors of allogeneic hematopoietic cell transplant (alloHCT), leading to irreversible pulmonary impairment, poor quality of life, and 5-year survival o…
Jannette Yvonne Berkley-Patton · UNIVERSITY OF MISSOURI KANSAS CITY · 2024 · $627,991 — PROJECT ABSTRACT Wide-reaching efforts are needed to increase population levels of physical activity and healthy eating in low- income groups for obesity- and type 2 diabetes prevention/control. Low-income groups experience higher rates of obesity and diabetes than the general population and the COV…
Arno Klein · MIRESOURCE, INC. · 2024 · $498,809 — SUMMARY This proposal addresses a significant barrier to obtaining treatment for college-age youth with mental disorders. Many college-age youth with impairing mental disorders remain untreated because of concerns about stigma and privacy, inconvenience and wait times, and because universities are o…