Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Sameer Kadri · CLINICAL CENTER · 2024 — Co-resistance necessitating use of less effective or relatively toxic reserve antibiotics (aminoglycosides, tigecycline and colistin/polymyxin B) may worsen survival. We investigated difficult-to-treat resistance (DTR) in gram-negative bloodstream infections (GNBSIs) defined by absence of susceptibi…
Jian-Liang Li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $2,844,821 — The Integrative Bioinformatics (IB) Support Group provides expertise in computational analysis and develops bioinformatics tools and resources to empower scientific research programs. Equipped with advanced computational infrastructure, including a comprehensive collection of bioinformatics software…
Bradford Wood · CLINICAL CENTER · 2024 — The Center for Interventional Oncology (CIO) was established at the NIH Clinical Center (CC) to develop and translate image-guided multi-modality multidisciplinary technologies for localized cancer treatments. The Center is a collaboration involving CC and NCI. The Center draws on the strengths of e…
Wing Pui Kong · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $912,113 — The Virology Core has collaborated with other intramural NIAID labs help to develop a pan-coronaviruses spike protein subunit vaccine and re-emerging infectious diseases. During the past year, we focused on developing the potent SARS-CoV2 vaccine against most recent SARA-CoV2 variants. We success…
Daniel Pine · NATIONAL INSTITUTE OF MENTAL HEALTH · 2024 · $1,480,585 — This work is conducted under protocol 03-M-0186, NCT00060775. In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. Such work has major public impact. By identifying biological risks in children, information on novel treatments and preventativ…
kathleen r merikangas · NATIONAL INSTITUTE OF MENTAL HEALTH · 2024 · $579,583 — Maintaining our ongoing collaboration with the CMI team in New York, we examined parental perceptions (both positive and negative) of internet use in adolescents via analyses of survey data from 1005 parents of adolescents (Kimball et al, 2023). This analysis revealed significant concerns about yout…
Sitara Swarna Rao Ajjampur · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $628,021 — PROJECT SUMMARY Soil-transmitted helminth (STH) infections (intestinal worms) affect 1.5 billion individuals globally. Recent evidence from trials and modeling studies suggests that community-wide mass drug administration (cMDA) of deworming medication with sufficient coverage and adherence can eli…
VESNA D GAROVIC · MAYO CLINIC ROCHESTER · 2024 · $355,156 — PROJECT SUMMARY/ABSTRACT In the inaugural round of the Stimulating Access to Research in Residency (StARR) program, Mayo Clinic’s residency research training model achieved substantial success. With a focus on heart (and vascular), lung, hematologic (blood), and sleep (HLBS) disorders/diseases align…
PHILIP Louis FELGNER · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $33,116,067 — Project Summary/Abstract – Overall: The UCI Vaccines for Pandemic Preparedness Center (VPPC) The Mission: "To contribute to human health and well-being by developing agile, safe, effective and accessible vaccines that protect the vulnerable against future pathogens of pandemic importance and by edu…
Sun Hur · BOSTON CHILDREN'S HOSPITAL · 2024 · $442,500 — SUMMARY MDA5 is a conserved innate immune receptor that detects viral RNAs during infection and activates antiviral immune response. Recent studies have shown that MDA5 can be activated not only during infection, but also under various physiological conditions in the absence of infection. Such “ste…
JILL Allison HOLLENBACH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $788,776 — SUMMARY Located within the human Major Histocompatibility Complex (MHC) chromosome 6p21, the Human Leukocyte Antigen (HLA) region is the most medically important region of the human genome. Variation in the HLA region has been associated with over 150 diseases and conditions, including infectious di…
Sangeeta Gupta · DELAWARE STATE UNIVERSITY · 2024 · $4,000,313 — Interdisciplinary Health Equity Research (IHER) Center Summary The COVID-19 pandemic put a spotlight on our nation’s stark disparities in health and the disproportional burden of disease related to race, ethnicity, and socioeconomic status. Delaware is an ideal state for a health disparities-focuse…
EILEEN M BULGER · UNIVERSITY OF WASHINGTON · 2024 · $764,193 — ABSTRACT Life-threatening traumatic exposures requiring presentation to acute care medical settings are endemic in the US in the era of the COVID-19 pandemic, firearm proliferation, and extreme weather events, and constitute both a substantial source of individual suffering and a significant public …
Agostina Casamento Moran · HUGO W. MOSER RES INST KENNEDY KRIEGER · 2024 · $99,113 — PROJECT SUMMARY Fatigue is one of the most common and debilitating symptoms in neurological, psychiatric, and other chronic illnesses; however, it remains poorly understood and undertreated. Post-acute sequelae of SARS-CoV-2 infection (PASC) is a novel syndrome characterized by a range of symptoms p…
Henrieta Scholtzova · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $821,911 — PROJECT SUMMARY Dysregulation of innate immunity is thought to be a significant contributor to Alzheimer’s disease (AD) pathogenesis. We have focused on harnessing innate immunity via Toll-like receptor 9 (TLR9) to modulate age- related defects in immune cells to counteract AD pathology. Our finding…
Neset Hikmet · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $131,713 — Abstract Today, a critical mass of previously collected linked health care data is now available for optimizing patient health outcomes. Information, insights, and intelligence existing in such health care data can be unlocked efficiently using Big Data Science (BDS).As people age and live longer, i…
Christopher R Bilder · UNIVERSITY OF NEBRASKA LINCOLN · 2024 · $429,353 — Project Summary/Abstract Testing high volumes of clinical specimens for infectious diseases requires the use of efficient testing approaches. One approach used by laboratories is a procedure known as group testing (also known as pooled testing). In its most basic application, portions of specimens fr…
Maria Corrada · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $5,224,302 — Project Summary The Life After 90 Study is a lifecourse cohort study of Alzheimer's disease and related dementia (ADRD), cerebropathology, and cognitive aging in diverse oldest-old individuals. Recently launched, and still enrolling, LA90 is the largest, most ethnic/racially diverse cohort study of …
Elysia Larson · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $176,651 — Depression and anxiety are the most common complications of pregnancy and the postpartum period, affecting one in five birthing people. Despite effective interventions for prevention and treatment, most perinatal depression and anxiety is unprevented and untreated, especially among marginalized comm…
Jacques E. Chelly · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $524,156 — PROJECT SUMMARY: Perioperative prescription of opioids is an important contributor to the current opioid epidemic, affecting ~4% of >50 million Americans undergoing surgery each year. The dose and duration of treatment of opioid in surgical patients is an established risk factor of opioid use disord…