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Principal Investigator: Maria Corrada
Organization: UNIVERSITY OF CALIFORNIA AT DAVIS
Fiscal Year: 2024
Award: $5,224,302
Funding agency: National Institute on Aging
Project Summary
The Life After 90 Study is a lifecourse cohort study of Alzheimer's disease and related dementia (ADRD),
cerebropathology, and cognitive aging in diverse oldest-old individuals. Recently launched, and still enrolling, LA90 is the
largest, most ethnic/racially diverse cohort study of the oldest-old with prospective clinical and lifestyle data from as early
as 1960/70s. In Cycle 1, we enrolled 908 individuals aged 90+ (mean age 92.6, range 90-105) from a range of enthoracial
backgrounds (22% Black, 24% Asian, 20% Latino, 28% White, 1% Other, 6% Multi-Race). Participants are seen every 6
months with an average of 2.9 research visits per person to date. All visits include an extensive neuropsychology battery
and clinical exam, research interview including measures of lifecourse social experience, brain donation program, and,
among a subset, PET and MRI imaging. The LA90 cohort encompasses an array of life experiences, 17% were born
outside of the US, 35% have <high school education, 40% are multilingual or learned English as a second language, and
24% born in southern US. Our initial findings suggest that there is vast heterogeneity and complexity in the trajectory of
cognitive change, brain pathologies, and neuroimaging markers of brain status in the 10th and 11th decade of life. In this
competitive renewal application, we extend our science to investigate blood-based biomarkers for ADRD in oldest-old
using the ATN framework (amyloid, tau, neurodegeneration), expand our brain donation-based pathology, and enroll an
additional 500 ethnic/racially diverse participants. Additionally, we will leverage decades of antecedent health data
available to identify early and midlife markers for oldest-old cognitive `SuperAgers'. Our aims are: Aim 1. Enroll 500
additional oldest-old individuals to determine more precise age-specific, race-specific, and sex- specific incident rates of
cognitive impairment, ADRD, and cognitive decline over 8 years. Aim 2: Determine the contribution of neuroimaging
markers of amyloid, vascular injury, and brain atrophy on cognitive decline and ADRD in diverse oldest-old. Aim 3:
Continue enrollment into brain donation and characterize the contribution of brain pathologies on cognitive decline, and
ADRD in the oldest-old. Aim 4: Collect and quantify blood-based biomarkers consistent with the ATN framework and
evaluate their contribution to ADRD and cognitive impairment in diverse oldest-old individuals. Aim 5: In a diverse
cohort of oldest-old, identify and understand lifecourse predictors of cognitive `SuperAgers'. Renewal of LA90 will create
an unprecedented scientific resource for studying ADRD and cognitive outcomes in a diverse cohort of oldest-old
individuals, a group representing the rapid diversification of this population.
Terms: <0-11 years old><AD dementia><AD pathology><AD related dementia><ADRD><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease biological marker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related dementia><Alzheimer's pathology><Alzheimers Dementia><Alzheimer’s biological marker><Alzheimer’s disease biomarker><Amentia><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Asian><Astroprotein><Atrophic><Atrophy><Autopsy><Aβ><Biological Markers><Black><Black race><Blood Vessels><Brain><Brain Nervous System><Brain Pathology><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><California><Child><Child Youth><Children (0-21)><Clinical Data><Clinical Evaluation><Clinical Testing><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Cohort Studies><Concurrent Studies><Coronavirus Infectious Disease 2019><Data><Dementia><Disturbance in cognition><Early identification><Education><Educational aspects><Elderly><Encephalon><Enrollment><Epidemiology><Ethnic Origin><Ethnicity><Exposure to><Female><GFA-Protein><GFAP><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Goals><Health><Health Inequity><Heterogeneity><Image><Impaired cognition><Incidence><Individual><Inequalities in Health><Inequities in Health><Interview><Language><Latino><Learning><Life><Life Cycle><Life Cycle Stages><Life Experience><Light><MR Imaging><MR Tomography><MRI><MRI biomarker><MRI marker><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Multilingualism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuron Degeneration><Neuropsychologies><Neuropsychology><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nuclear Magnetic Resonance Imaging><Older Population><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathology><Pattern><Persons><Phone><Photoradiation><Population><Position><Positioning Attribute><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Psychosocial Factor><Race><Races><Rad.-PET><Research><Research Resources><Resources><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Science><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><TAR DNA-binding protein 43><TDP-43><TDP43><Telephone><Visit><Woman><Zeugmatography><a beta peptide><abeta><advanced age><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><amyloid beta><amyloid-b protein><beta amyloid fibril><bio-markers><biologic marker><biomarker><blood-based biomarker><blood-based marker><brain atrophy><cardiovascular risk><cardiovascular risk factor><cerebral atrophy><clinical exam><clinical examination><clinical test><co-morbid><co-morbidity><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cohort><comorbidity><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><cortical atrophy><enroll><epidemiologic><epidemiological><ethnoracial><experience><geriatric><health data><health inequalities><high school><imaging><injury to the vasculature><kids><life course><life-style data><lifestyle data><magnetic resonance imaging biomarker><magnetic resonance imaging marker><men><microtubule bound tau><microtubule-bound tau><mid life><mid-life><middle age><middle aged><midlife><mild cognitive disorder><mild cognitive impairment><multi-ethnic><multi-racial><multiethnic><multilingual><multiracial><necropsy><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neurofilament><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic><neuropathological><neuropathology><neuropsychologic><older groups><older individuals><older person><participant enrollment><patient enrollment><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><postmortem><primary degenerative dementia><programs><prospective><protective factors><protein TDP-43><protein TDP43><psychosocial variables><racial><racial background><racial diversity><racial origin><racially diverse><research clinical testing><senile dementia of the Alzheimer type><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex><social><soluble amyloid precursor protein><super ager><tau><tau Proteins><tau factor><vascular><vascular injury><vascular risk factor><youngster><τ Proteins>