Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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MARK S SMELTZER · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $228,000 — PROJECT SUMMARY/ABSTRACT A primary means of research support for investigators in the Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR) in Phase III will be the NIGMS-funded Pilot Grant Program (PGP), supplemented with institutional funds ($100,000 per year for each year…
Katherine W Ferrara · STANFORD UNIVERSITY · 2020 · $655,422 — Abstract of: Proposed COVID-19-related supplement to In vivo PET imaging of novel engineered AAVs informs capsid design There is an urgent need to develop tools to assess viral pathogenesis and the efficacy of potential therapeutics for novel viruses such as SARS-CoV-2. While organoid and cell-base…
Jonathan Himmelfarb · UNIVERSITY OF WASHINGTON · 2020 · $300,384 — PROJECT SUMMARY / ABSTRACT The ongoing coronavirus 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), and has led to over one million reported cases, significant morbidity and mortality, and extensive economic and societal disruption. The development …
Emanuela Marina Bruscia · YALE UNIVERSITY · 2020 · $412,285 — PROJECT SUMMARY Macrophages (MΦs) kill microorganisms, engulf dead cells and debris, and regulate the immune response. They are thus gatekeepers of tissue health, including the lungs. The lung-tissue-resident MΦs (TR-MΦs) are the interstitial and alveolar MΦs, which have complementary but distinct f…
JOHN B MACMILLAN · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2020 · $241,894 — PROJECT SUMMARY Viruses are cleverly dangerous; they jump from species to species, mutate to evade vaccines and single antiviral drugs, and cause many human diseases and deaths. A notorious and current example is Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2; hereafter abbreviated SARS…
Michael B Fessler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $56,896 — This project was funded earlier this summer (2020). To date, we have already: 1) contracted with Avanti Lipids to synthesize enantiomeric 25-hydroxycholesterol (25HC), which will be used as a control for 25HC to help distinguish protein-targeted vs. non-protein-targeted (membrane) effects of this o…
Joseph Shiloach · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2020 · $716,829 — Summary: An essential part of the Lab activities is the production of high-quality, unique biologicals that are not available from commercial sources. During the last year the Lab performed several processes, which include propagation of bacteria, yeast, insect cells, and mammalian cells (in volume…
Leesa Deterding · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $617,969 — Mass spectrometry has been used to determine the extent of modification and the specific sites of modification on biomolecules. MS-based approaches have many advantages, including generally rapid analyses without radiolabeling. The MS analysis of a variety of proteins has been investigated using mas…
JAY A BERZOFSKY · DIVISION OF BASIC SCIENCES - NCI · 2020 · $512,699 — This project just began in April, 2020, during the COVID-19-induced closure of NIH labs, with very few people allowed to work, so it is very early ( 3 months) and progress is limited on each of the above sub-studies. In vitro studies in macaque bronchioalveolar lavage cells: So far, we have seen som…
Thomas Waldmann · DIVISION OF BASIC SCIENCES - NCI · 2020 · $476,661 — Dr. Liyanage P. Perera, a member of our group, is an expert in the introduction of IL-15 into vaccines to augment their function. He is working on 2 candidate vaccines for COVID-19, a full-length spike S protein, as well as a truncated subdomain of it that carries the receptor-binding domain of a Na…
alexander wlodawer · DIVISION OF BASIC SCIENCES - NCI · 2020 · $112,033 — Recently, angiotensin-converting enzyme 2 (ACE2) was shown to be a functional receptor for SARS-CoV-2, enabling the virus to enter host target cells. Using structure-based rational design, a chimeric ACE2 peptide was designed by us for use as a ligand for analytical quantitation of SARS-CoV-2. We ai…
Bernard R Brooks · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2020 · $1,067,238 — pH dependance of a Na channel Sodium ion channels play an important role in electrical signaling in cells; as such they are the targets of many drugs, as well as naturally occurring toxins from plant and animal sources. Inhibition and/or improper functioning of sodium channels due to mutation can …
Ursula Buchholz · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $279,642 — We previously constructed a first-generation construct called HPIV3-EbovZ GP, in which the complete genome of the JS strain of HPIV3 was modified by the addition of the EBOV GP gene in the third gene position, between the HPIV3 P and M genes. The JS strain is thought to be an attenuated HPIV3, based…
Bernard Moss · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $1,341,664 — There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to develop new vectors, characterize viral antigens, determine targets of humoral and cell mediated immunity, and use this i…
PETER D. SUN · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $143,327 — To characterize the SARS-CoV-2 spike protein interaction with lectin receptors, we have expressed recombinant SARS-CoV-2 spike prefusion trimer using 293F freestyle expression system. Given the nanomolar high affinity of the spike protein binding to human ACE2, the entry receptor for SARS-CoV-2, an…
Matthew Hall · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2020 · $859,275 — During this past reporting period, NCATS began development of over a dozen novel assays to screen for potential therapeutic agents against SARS-CoV-2. Optimized assays were then screened against a panel of drug repurposing, clinical candidate and antiviral libraries that have been assembled at NCAT…
Aravind Iyer · NATIONAL LIBRARY OF MEDICINE · 2020 · $1,458,093 — The origin of eukaryotes was marked by the emergence of several novel subcellular systems. One such is the calcium (Ca2+)-stores system of the endoplasmic reticulum, which profoundly influences diverse aspects of cellular function including signal transduction, motility, division, and biomineralizat…
Anton Simeonov · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2020 · $153,460 — Phage display is one of most effective molecular diversity techniques, it has been used for the selection of antibodies from diverse libraries. Several facilities (Uchicago, Utoronto, UCSF) in the world have built automated phage display robot for generation of conventional antibodies to the proteom…
Jason Matthew Elinoff · CLINICAL CENTER · 2020 — Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), a novel coronavirus identified in December 2019, is now responsible for an expanding pandemic resulting so far in more than 300,000 deaths worldwide. While hypoxic respiratory failure due to SARS-CoV2 pneumonia is the most common presentat…
Audray Harris · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $37,194 — Coronaviruses remain both a seasonal health burden and pandemic threat due to the antigenic variation of viral glycoproteins and the ability of animal coronaviruses to cause zoonotic infections in humans. Although conserved epitopes have been identified, there is a fundamental gap in understanding a…