Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Claire D. Coles · EMORY UNIVERSITY · 2024 · $2,217,469 — Project Summary/Abstract Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal sub…
REINHARD LAUBENBACHER · UNIVERSITY OF FLORIDA · 2024 · $731,876 — PROJECT SUMMARY/ABSTRACT A key feature of the COVID-19 infection is the vast inter-individual heterogeneity in the severity of the infection. The complex biological mechanisms that underlie this variability remain mostly obscure. We propose to provide a mechanistic understanding of this susceptibil…
Susan Bailey Gurley · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $540,092 — Project Summary Hypertension affects more than 60 million people in the US and despite its diverse causes, blockade of the renin-angiotensin system (RAS) lowers blood pressure in the majority of hypertensive patients. ACE2 is the newest member of the RAS, and our previous work has established that A…
Feng Guo · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $478,737 — Project Summary (Abstract) Developing three-dimensional antisense oligonucleotide drugs against COVID-19 The culprit of coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2), has a very large RNA genome that encodes the proteins and RNA el…
Patrick T Davies · UNIVERSITY OF ROCHESTER · 2024 · $595,244 — Modified Project Summary/Abstract Section External stressors have implications for the health and well-being of families and children, including increased domestic violence and harsh parenting. Despite evidence indicating that these may increase rates of interparental hostility and parent-child dif…
R. PAUL JOHNSON · EMORY UNIVERSITY · 2024 · $74,999 — PROJECT SUMMARY With this R13 application, we request funding to support, in part, the costs for planning, publicizing, and hosting the 39th, 40th, and 41st Annual Symposia on Nonhuman Primate Models for AIDS. For four decades, this symposium has served as the premier scientific forum for the exchan…
Delesha Miller Carpenter · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $540,077 — PROJECT SUMMARY From May 2020 to April 2021, more than 100,000 individuals died of a drug overdose, making it the leading cause of injury death in the United States.[1] The increase in the overdose death rate has been higher in American Indian/Alaska Native (AI/AN) and Black people, with the overdos…
Derek Tramel Dangerfield II · GEORGE WASHINGTON UNIVERSITY · 2024 · $811,432 — Project Summary/Abstract The U.S. will not meet the targets of the Ending the HIV Epidemic Plan (EHE) without an intentional focus on improving outcomes among Black sexual minority men living with HIV (BSMM LWH). Only 55% of BSMM LWH maintain 100% daily treatment adherence and only 62% are virally …
Kelly R. Peck · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2024 · $693,303 — PROJECT ABSTRACT Nearly 90% of individuals with OUD report lifetime trauma exposure and 33% meet criteria for PTSD. Patients with co-occurring PTSD and OUD are at significantly greater risk for poor substance use and mental health outcomes vs. those with OUD alone. Although Prolonged Exposure (PE) …
Gregory Seumois · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2024 · $25,000 — PROJECT SUMMARY Disease associated with allergies such as asthma are a rising health problem with no current curative solutions. CD4+ helper T cells (TH) that respond to common allergens play an important role in driving airway inflammation in asthma. To better understand the diversity of T cell sub…
Ellen Elizabeth Sparger · TENDEL THERAPIES INC. · 2024 · $571,691 — Tendel’s CoTend-s3B SARS-CoV-2 booster vaccine targets T follicular helper (Tfh) cells to generate extraordinarily broad and long-lived antibody responses, which are required for resilient vaccines that maintain protection over long periods. The vaccine candidate incorporates the “s3” targeting moie…
Megan T Baldridge · WASHINGTON UNIVERSITY · 2024 · $233,250 — PROJECT SUMMARY/ABSTRACT Laboratory mice exhibit underdeveloped immune systems which fail to accurately predict human responses to challenges such as vaccination. Intentional exposure of these mice to environmental microbes (creating “dirty” mice) through various approaches has been shown to confer…
DANIEL KAUFMAN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $236,250 — ABSTRACT New SARS-CoV-2 variants and novel coronaviruses will constantly arise and affect large proportions of the worldwide population. Although the current wave of infections with Omicron subvariants is much less lethal than that caused by previous SARS-CoV-2 variants (e.g., Wuhan-Hu1, Alpha, and…
Sanghyun Lee · BROWN UNIVERSITY · 2024 · $242,350 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 19 (COVID-19), representing a global health threat. The viral spike protein, anchored on the surface of the viral envelope as homotrimers, binds to angiotensin-converting enzyme 2 (ACE2) and me…
Andres Chang · EMORY UNIVERSITY · 2024 · $192,888 — Project Summary Non-Hodgkin lymphoma and chronic lymphocytic leukemia (NHL/CLL) patients have immune system deficits that arise from the cancer and are aggravated by lymphoma therapies, placing them at higher risk of morbidity and mortality after infection with viruses like influenza and severe acut…
Simon Neil Vandekar · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $425,395 — PROJECT SUMMARY Identifying brain-behavior associations for the purpose of informing individual differences, illness trajectories, and neural mechanisms is one of the primary goals of psychiatric neuroimaging. The massively multivariate nature of neuroimaging data, which consists of spatially detail…
Tony John Ward · UNIVERSITY OF MONTANA · 2024 · $255,235 — Project Summary / Abstract Climate change impacts are accelerating throughout the world. In the western US and Alaska, we are seeing significant increases in the frequency of wildfires, with smoke impacting our rural communities nearly every summer and fall. Children growing up these rural and medic…
RICHARD YUQI ZHAO · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $233,250 — Abstract The COVID-19 pandemic caused by SARS-CoV-2 has presented unprecedented challenges due to its rapid spread, mutability, high death rate, and long-term complications. Vaccines have shown efficacy but wane over time, and new variants emerge. Antiviral drugs offer an effective alternative, but …
Ye Shen · UNIVERSITY OF GEORGIA · 2024 · $377,500 — PROJECT SUMMARY Predictive models play an essential role in disease prevention and control. Recent advances in scientific research have allowed more thorough and in-depth data collection from epidemiological studies (e.g., GPS data, climate data, wearable device data). However, due to the many varia…
COLTER M.S. MITCHELL · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $594,081 — The COVID-19 pandemic, transmission mitigation strategies and policies implemented across the United States led to major disruption in day-to-day life, producing immediate effects on individuals, families and communities. We hypothesize that the pandemic will have broadly negative health and economi…