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9873 documents

BRidging Information Divides and Gaps to Ensure Survivorship: the BRIDGES Randomized Controlled Trial of a Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

NINA S KADAN-LOTTICK · GEORGETOWN UNIVERSITY · 2024 · $625,358 — PROJECT SUMMARY More than 80% of childhood cancer survivors (CCS) develop serious or life-threatening late effects. Yet <20% of CCS receive recommended survivorship care, despite the availability of consensus guidelines for lifelong surveillance for late effects starting 2 years post-therapy. The “g…

Nosocomial pneumonias impair cognitive function

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Mike Lin · UNIVERSITY OF SOUTH ALABAMA · 2024 · $453,573 — PROJECT SUMMARY/ABSTRACT Patients in intensive care units are at high risk for long-term health threats including cognitive impairment. The correlation was only recently revealed after large-scale follow-up cognitive assessments on intensive patient survivors after their discharge from the hospital.…

Meaning-Centered Grief Therapy for Parents Bereaved by Cancer: A Multisite Randomized Controlled Trial

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Wendy G. Lichtenthal · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $585,321 — Project Summary/Abstract Bereavement support is a core tenet of comprehensive palliative care. Yet, accessible, evidence-based interventions are limited, particularly for bereaved parents. Losing a child to cancer is one of the most devastating experiences a parent can endure. Bereaved parents are a…

Advancing Geriatrics Infrastructure and Network Growth (AGING) Initiative

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JERRY H GURWITZ · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $856,122 — PROJECT SUMMARY / ABSTRACT The Health Care Systems Research Network (HCSRN)-Older Americans Independence Centers (OAICs) AGING (Advancing Geriatrics Infrastructure and Network Growth) Initiative (R24AG045050/R33AG0577806) was launched in 2014 to address knowledge gaps around multiple chronic conditi…

Examining the Interplay of COVID-19 and HIV: Impacts on HIV Care, Disparities, and Long-Term Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

McKaylee Robertson · GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY · 2024 · $148,824 — Abstract COVID-19 may have negatively impacted efforts aimed at EHE and exacerbated disparities in HIV outcomes. For EHE to be successful, it is important to understand any lasting impacts that adversely complicate HIV control and impact care of people with HIV (PWH), and to address structural issu…

Inhibitors of Thromboinflammation for Acute Kidney Injury

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Christopher Dockendorff · FUNCTION THERAPEUTICS, INC. · 2024 · $325,000 — Acute kidney injury (AKI) is the sudden and dangerous loss of kidney function that causes significant morbidity and mortality. A significant fraction of patients undergoing major surgery suffer from AKIs, particularly cardiac patients, with >10% probability of AKI frequently reported. Almost half of…

Bayesian Mortality Estimation from Disparate Data Sources

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JONATHAN C WAKEFIELD · UNIVERSITY OF WASHINGTON · 2024 · $308,048 — Project Summary: The goal of the proposal is to develop a Bayesian statistical framework for mortality estimation from disparate data sources. Using this framework we will produce a suite of principled methods to be used in those situations in which vital registration data are lacking. We will empha…

Improving Perception in Digital Breast Tomography

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jeremy M Wolfe · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $429,319 — Digital Breast Tomosynthesis (DBT) is a breast cancer screening methodology in which radiologists search for cancer in 3D volumes of virtual slices through the breast. DBT performs better than classic, 2D mammography but it takes more time. Our goal is to compare different methods that could reduce …

Digital data streams and machine learning for real-time modeling of vaccine-preventable infectious diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Maimuna Shahnaz Majumder · BOSTON CHILDREN'S HOSPITAL · 2024 · $442,337 — Over the last 30 years, a new field––known as computational epidemiology (comp epi)––has emerged at the intersection of digital data streams (e.g., news and social media, search query, and mobility data), machine learning (e.g., nonlinear optimization, natural language processing, and agent-based mo…

TELE-TOC: Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients - Resubmission - 1

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Joanna Abraham · UNIVERSITY OF CHICAGO · 2024 · $399,991 — PROJECT ABSTRACT Transitions of Care (TOC) for high-risk, frequently hospitalized adults with chronic diseases are complex, costly, and vulnerable to safety threats and poor health outcomes. Communication breakdowns, information lapses, and IT-induced unintended consequences can result in poor follo…

Development of peptide nucleic acid antibiotics

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

DEV PRIYA ARYA · NUBAD, LLC · 2024 · $33,272 — The world is rapidly heading towards a pre-1940’s scenario when it comes to fighting infectious disease. Antimicrobial resistance is a growing problem on a global scale, greatly hampering our abilities to quell worldwide epidemics such as influenza, SARS, COVID-19, tuberculosis and malaria, as well …

Multilevel Panel Study of Effects of Changes in Nursing on Health Equity and Patient Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Matthew D. McHugh · UNIVERSITY OF PENNSYLVANIA · 2024 · $782,833 — The organizational context in which nursing care is delivered plays a key role in health outcomes for patients. Through our NINR-sponsored program of research, continually funded since inception, we have produced vital information from large and representative samples of organizations (e.g., hospita…

Effective local delivery of bone anabolic agent to accelerate the healing of delayed fracture union

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Dong Wang · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $427,763 — ABSTRACT Fracture is the leading musculoskeletal injury affecting over 9.4 million Americans annually. Approximately ~10% of fractures are complicated by delayed healing or non-union, resulting chronic pain, impaired mobility and poor quality of life. Pathophysiological and habitual risk factors, i…

Genetic and Immuno-inflammatory Drivers of Post-acute Pulmonary Sequelae of SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Steven B Abramson · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $830,331 — ABSTRACT The goal of this proposal will be to study the frequency, chronicity and etiology of post-acute sequelae of SARS CoV-2 with protocols designed to characterize genetic and immuno-inflammatory factors that influence post- COVID complications. We will establish a cohort of 1200 or more deeply …

Tulane StARR Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

JAY K KOLLS · TULANE UNIVERSITY OF LOUISIANA · 2024 · $253,049 — PROGRAM SUMMARY This is the first renewal application for the Tulane StARR Program which successfully recruited a diverse cadre of 6 StARR Scholars who are actively engaged in mentored research training in heart, lung, and blood (HLB) diseases in the last 2.5 years. The long-term goal is to increase…

U-RISE at Howard University

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Shawn Maurice Abernathy · HOWARD UNIVERSITY · 2024 · $271,543 — Summary/Abstract The United States (US) biomedical science (BMS) enterprise critically lacks diversity at the Ph.D. level. This problem is due to the lack of underrepresented minority (URM) students at the undergraduate level majoring in STEM (science technology engineering and mathematics) discipli…

Innovative web-based service platform called Adult Wellbeing CheckUp (AWC) to assess older adults wellbeing, obtain evidence-based recommendations, and receive support to take action

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

James P Firman · BELLAGE, INC. · 2024 · $497,829 — PROJECT SUMMARY / ABSTRACT Older adults in America are living longer, and there are more of them than at any other time in the country’s history. U.S. adults aged 65 and older are expected to increase from 54 million in 2020 to over 80 million by 2040. Older adults are at risk for poor health in man…

Human immune memory to COVID-19, vaccines, and respiratory pathogens

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Shane P Crotty · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2024 · $2,595,434 — OVERALL COMPONENT SUMMARY Our LJI CCHI was first funded in April of 2019 and has been highly impactful in human immunology research in the past < 4 years, particularly in the areas of COVID and COVID vaccines. Crotty and Sette published the first major paper on virus-specific T cell and antibody res…

Inhalable stem cell exosome therapy for cardiac injury

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ke Cheng · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2024 · $751,983 — PROJECT SUMMARY Myocardial infarction (MI) happens when the blood flow in one or more coronary vessels are blocked. Due to the limited regenerative capability of the heart, this can lead to life-threatening heart failure (HF). End- stage HF usually requires heart transplantation. Stem cells have be…

Mechanisms of mitochondrial-ER communication during dietary and thermal induced stress

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Pedro Antonio Latorre Muro · DANA-FARBER CANCER INST · 2024 · $90,000 — Project Summary/Abstract Obesity is a pandemic affecting 40% of the population that increases the risk of serious metabolic diseases including type 2 diabetes and severe forms of SARS-CoV2 infection. Obesity reduces insulin sensitivity and dysregulates glucose homeostasis sustaining high blood gluco…