Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
ROBERT A. BONOMO · CASE WESTERN RESERVE UNIVERSITY · 2024 · $574,870 — The Centers for Disease Control and Prevention (CDC) designated Carbapenem-Resistant Acinetobacter baumannii (CRAb) an “urgent threat pathogen” for which novel therapies are desperately needed. The current COVID-19 pandemic has only accelerated the emergence of CRAb in medical intensive care units a…
Kasey Lynn Brida · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $42,629 — PROJECT SUMMARY Substance use disorder (SUD) is a national health crisis, with over 93,000 deaths due to overdose in 2020. Currently, no FDA-approved therapeutics exist for SUD, with targeted therapeutics out of reach due to incomplete understanding of the neurobiology of addiction. Our lab has iden…
JORGE C BLANCO · SIGMOVIR BIOSYSTEMS, INC. · 2024 · $488,080 — For more than a decade, our work has focused on development of therapeutic interventions for viral- and bacterial-induced acute lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS). Significantly, we identified the Toll-like receptor 4 (TLR4) signaling pathway as key to t…
Paul L Reiter · OHIO STATE UNIVERSITY · 2024 · $196,875 — PROJECT SUMMARY Two issues related to adolescent vaccination have recently come to the forefront of public health in the United States (US): coronavirus disease 2019 (COVID-19) vaccination and general vaccine hesitancy (i.e., a delay or refusal of any vaccination despite availability). These issues …
Kyle H Rohde · UNIVERSITY OF CENTRAL FLORIDA · 2024 · $237,288 — Project Summary Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is responsible for staggering levels of morbidity and mortality, with ~1.7 million deaths and ~10 million new cases each year. The current TB regimens for drug susceptible strains, entailing multidrug cocktails for ≥4 mon…
Bryan R Greenhouse · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $524,724 — ABSTRACT Genomic data can provide an invaluable source of information to understand pathogen evolution, identify patterns of transmission, and characterize phenotypes such as drug resistance and immune escape. For eukaryotic pathogens, larger genomes, sexual recombination, and complicated transmissi…
Rie Sakai-Bizmark · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · 2024 · $259,773 — PROJECT SUMMARY Suicide is a major public health problem in the U.S., ranking as the second leading cause of death among teens, with a rate of 7.1 per 100,000 population in this age group. Previous studies have revealed seasonal trends and day-of-the-week effects in adolescent suicidal behavior, suc…
Ulas Bagci · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $772,290 — PROJECT SUMMARY Since the beginning of COVID-19 (SARS-CoV-2) pandemic, we have seen a number of prominent variants, and two of them are very recent. COVID-19 continues to affect millions of people: over 771 million people were affected and over 6.9 million deaths occurred (as of October 2023). A sig…
Kabayam M Venkat Narayan · EMORY UNIVERSITY · 2024 · $75,864 — OVERVIEW: PROJECT SUMMARY / ABSTRACT While considerable evidence is available for prevention and care of diabetes, huge gaps remain in equitable and sustainable translation of this knowledge into practice and policy in clinical and community settings. To close these gaps, the Georgia Center for Diab…
Anjail Z Sharrief · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $159,200 — A. SUMMARY AND SPECIFIC AIMS OF FUNDED PARENT GRANT Hypertension is the most important risk factor for ischemic and hemorrhagic stroke, and reduction in blood pressure (BP) after stroke is associated with reduced risk of stroke recurrence. For the majority of stroke survivors (SS), hypertension rema…
Christopher Benton Whitehurst · NEW YORK MEDICAL COLLEGE · 2024 · $247,500 — Project Summary/Abstract Epstein-Barr Virus (EBV), a human tumor virus, is the causative agent of mononucleosis and immunoblastic lymphomas. EBV is strongly associated with Burkitt’s lymphoma, Hodgkin’s lymphoma, and nasopharyngeal carcinoma (NPC). Additionally, recent studies suggest that EBV has a…
Andrew Santiago-Frangos · UNIVERSITY OF PENNSYLVANIA · 2024 · $249,000 — The discovery of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems led to creative new applications that are transforming science and medicine. However, the rapid discovery of new CRISPR systems outpaces our understanding of their biological roles in anti-phage defense and t…
Benjamin J Doranz · INTEGRAL MOLECULAR · 2024 · $288,515 — ABSTRACT Neutralizing titer is a demonstrated correlate of protection across most viral pathogens. The traditional assay to assess neutralization titer is the plaque reduction neutralization test (PRNT), which is generally regarded as slow, subjective, and variable. To conduct large scale clinical v…
David B. Bekelman · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — Background: VA implemented the Life Sustaining Treatment Decisions Initiative (LSTDI) to elicit, document, and honor the values, goals, and preferences of Veterans with serious illness. The National Academy of Medicine recommends, and patients and families prefer goals of care conversations (the fou…
Amy Linsky · VA BOSTON HEALTH CARE SYSTEM · 2024 — Proactive goals of care conversations (GoCCs) conducted in advance of clinical deterioration are a hallmark of high-quality, patient-centered care. When done well, GoCCs allow healthcare providers to tailor end-of-life care to patient values and improve key outcomes for patients, caregivers, provide…
Catherine Bielick · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $191,484 — PROJECT SUMMARY People who present with Acquire Immunodeficiency Syndrome (AIDS) are at high risk of developing an opportunistic infection and death. Opportunistic infections (OIs) are any infection that is more frequent or more severe because of HIV-mediated immunosuppression. Different states in t…
Sannisha K Dale · UNIVERSITY OF MIAMI CORAL GABLES · 2024 · $72,588 — Background: Black women represent the largest group of women with HIV, both nationally, and locally in Miami, a U.S. HIV epicenter; and 40% are not virally suppressed. Further, they live at the intersection of multiple marginalized identities and within social structures that take a daily toll. Micr…
ALEXEY VLAD ONUFRIEV · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $44,647 — Project Summary. Progress in modern bio-molecular sciences, from structural biology to structure-based drug design, is greatly accelerated by methods of atomic-level modeling and simulations that bridge the gap between theory and experiment. The so-called implicit solvation model can provide critica…
DANIEL P DICKSTEIN · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · 2024 · $216,000 — Project Summary/Abstract: BACKROUND: NIMH and the National Academies of Sciences, Engineering, and Medicine have identified a critical shortage of child and adolescent psychiatry (CAP) researchers—paradoxically as most mental illnesses are recognized as having developmental origins, with impact acro…
Jason D Shepherd · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $53,897 — Abstract Synapses are the basis of neuronal communication and plasticity. Decades of research in reduced preparations have revealed fundamental principles of neuronal transmission and synaptic plasticity. This work identified key molecular constituents of synapses and pre- and postsynaptic mechanism…